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callicarpa nudiflora and nauclea officinalis traditional Chinese medicine composition and preparation method thereof

The technology of a composition and a traditional Chinese medicine is applied in the field of Chinese medicinal composition and preparation of A. chinensis, and can solve the problems such as unreported capsule effect, and achieve the effects of stable quality, simple preparation process and good therapeutic effect.

Inactive Publication Date: 2021-07-27
海南崇原药物开发有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] At present, there is no report on the best extraction process for the two kinds of traditional Chinese medicine raw materials, and the effect of the capsules prepared from the extract of Aurantia chinensis.

Method used

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  • callicarpa nudiflora and nauclea officinalis traditional Chinese medicine composition and preparation method thereof
  • callicarpa nudiflora and nauclea officinalis traditional Chinese medicine composition and preparation method thereof
  • callicarpa nudiflora and nauclea officinalis traditional Chinese medicine composition and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0036] Embodiment 1, the preparation technology of Zizhudanmu Chinese medicine extract powder

[0037] The present embodiment provides a preparation method of the traditional Chinese medicine composition of Zizhuanmu, which comprises the following steps:

[0038] In this embodiment, the water reflux extraction method is selected, the amount of water added (A), the extraction time (B), and the number of extractions (C) are used as the investigation factors, and 3 levels are selected for each factor, and the yield of traditional Chinese medicine extract is used as the investigation index. , to optimize the extraction method of Zizhudanmu extract, and the factor levels are shown in Table 1.

[0039] Table 1

[0040]

[0041]

[0042] Weigh the Auranthus nudaflora powder through the No. 4 sieve, accurately weigh 5g according to the ratio of 4:1, a total of 9 parts, and number them as test groups No. 1 to No. 9 in sequence, and carry out heating and reflux extraction accordi...

Embodiment 2

[0051] Embodiment 2, the preparation of Zizhudanmu Chinese medicine composition

[0052]1. Get 3 parts of Nadihuazizhu and Danmu medicinal materials, according to the ratio of 4:1, each part takes 10g, according to the optimal process conditions determined in Example 1, the medicinal material water extraction process is verified, and the measurement results are shown in the table 4 Orthogonal test of traditional Chinese medicine extract to verify the experimental results. The results showed that the optimal scheme determined above had a higher yield of extracting the extract of Zizhudanmu, and the scheme was more stable.

[0053] Table 4

[0054]

[0055] As can be seen from Table 4, the optimal scheme determined in Example 1 has a higher yield of extracting the extract of Auranthus japonica-Danmu, the scheme is relatively stable, and the process is reasonable and feasible.

[0056] 2. Extraction of Auranthus chinensis extract

[0057] Get through the No. 4 sieve of the ...

Embodiment 3

[0077] Embodiment 3, the preparation of Zizhudanmu Chinese medicine capsule

[0078] 1. Take 472g of the naked flower purple pearl medicinal material and 118g of the gallwood medicinal material that have been passed through a No. 4 sieve, add 20 times of water, extract 3 times, each time for 0.5 hours, combine the extracts, filter, heat, concentrate and dry to obtain 195g naked Dried extract of Auranthus japonica. The above-mentioned dry extract is pulverized, sieved and packed into capsules to obtain Zizhudanmu traditional Chinese medicine capsules.

[0079] The Zizhudanmu traditional Chinese medicine capsule of the present embodiment is a hard capsule, and the content is a tan powder with a slightly fragrant gas, slightly sweet taste, and slightly bitter taste.

[0080] 2. Take 0.1g of the contents of Zizhudanmu traditional Chinese medicine capsule, put it in a 1ml volumetric flask, add 65% methanol to dilute to 1ml, and sonicate for 30min. Allow to cool and make up with 6...

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Abstract

The invention discloses a preparation method of a callicarpa nudiflora and nauclea officinalis traditional Chinese medicine composition, which comprises the following steps: mixing callicarpa nudiflora and nauclea officinalis traditional Chinese medicine raw materials to form a traditional Chinese medicine mixture, adding water which is 20 times of the mass of the traditional Chinese medicine mixture into the traditional Chinese medicine mixture, heating, refluxing and extracting for three times for 0.5 hour each time, and merging the three traditional Chinese medicine extracting solutions; filtering the traditional Chinese medicine extracting solution, heating, concentrating and drying to obtain callicarpa nudiflora and nauclea officinalis traditional Chinese medicine extract powder; and mixing the obtained callicarpa nudiflora and nauclea officinalis traditional Chinese medicine extract powder with auxiliary materials according to a mass ratio of 1: 1, and filling to obtain the callicarpa nudiflora and nauclea officinalis traditional Chinese medicine composition. According to the preparation method of the callicarpa nudiflora and nauclea officinalis traditional Chinese medicine composition, the preparation process is simple, the prepared capsule is stable in quality, and the obtained callicarpa nudiflora and nauclea officinalis traditional Chinese medicine composition has the effects of diminishing inflammation, detoxifying, astringing and stopping bleeding. The traditional Chinese medicine composition has a good treatment effect on diseases such as respiratory tract inflammation, acute infectious hepatitis, respiratory tract and digestive tract hemorrhage and the like.

Description

technical field [0001] The invention relates to the technical field of medicine preparation, in particular to a traditional Chinese medicine composition and a preparation method thereof. Background technique [0002] The medicinal material of Nudiflora Hook.et Arn is the dried plant of Callicarpa (Callicarpa) of Verbenaceae, also known as Chaifengchai, Jiejiehong, etc. It is widely used in Guangdong, Hainan, and It is distributed in Malaysia and other places abroad. According to the 2020 edition of the "Chinese Pharmacopoeia", the medicinal material of nudibranch has anti-inflammatory, detumescence, detoxification, dampness and turbidity, and hemostasis. It is clinically used in the treatment of inflammation and swelling caused by bacterial infection, acute infectious hepatitis, and internal and external trauma and bleeding. There have been research reports that the main chemical components contained in Auranthus nudica are flavonoids, phenylpropanoids, and terpenoids. In...

Claims

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Application Information

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IPC IPC(8): A61K36/85A61P11/00A61P1/16A61P1/00A61P7/04A61P31/14A61P31/20A61K36/74
CPCA61K36/85A61K36/74A61P11/00A61P1/16A61P1/00A61P7/04A61P31/14A61P31/20A61K2236/331A61K2236/39A61K2300/00
Inventor 刘洋洋唐菲
Owner 海南崇原药物开发有限公司
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