Loxoprofen sodium gel and preparation method thereof

A technology of loxoprofen sodium and gel, which is applied to the gel of loxoprofen sodium and the field of preparation thereof, can solve the problem that loxoprofen sodium is not easy to penetrate the skin of the human body to absorb, has poor therapeutic effect, and has poor absorption effect. To achieve the effect of speeding up the progress of treatment, avoiding accidental ingestion, and taking effect quickly

Pending Publication Date: 2021-09-07
河南上恒医药科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The existing loxoprofen sodium gel cream has poor absorption effect during use, and loxoprofen sodium is difficult to penetrate the skin of the human body to be absorbed, and the therapeutic effect is poor

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] Embodiment one: a kind of gel of loxoprofen sodium, comprising 5 parts of loxoprofen sodium, 15 parts of gel substrate, 10 parts of antiseptic, 30 parts of humectant, 50 parts of ethanol solution, 3 parts of antioxidant , 10 parts of transdermal absorption accelerator, 5 parts of pH regulator, 5 parts of antibacterial agent, 10 parts of Coptidis rhizome, the added amount of described pH regulator is determined according to the actual solution pH value, and described loxoprofen sodium should be through precision grinding, and Use a high-mesh sieve to sieve the ground powder. The Coptidis rhizome is also ground and sieved with a high-mesh sieve. The preservative is added in three times, and each addition is one-third of the total amount. One, the loxoprofen sodium, preservative, humectant, and antioxidant are initially mixed, and after the mixing is completed, an ethanol solution is added for stirring, and then powdered Coptis rhizome is added to the solution, and the gel ...

Embodiment 2

[0039] Embodiment two: a kind of gel of loxoprofen sodium, comprising 5 parts of loxoprofen sodium, 20 parts of gel substrates, 10 parts of preservatives, 15 parts of humectants, 100 parts of ethanol solution, 3 parts of antioxidants 15 parts of transdermal absorption accelerator, 15 parts of pH regulator, 15 parts of bacteriostatic agent, 10 parts of Coptidis rhizoma, the addition amount of described pH regulator is determined according to the actual solution pH value, and described loxoprofen sodium should be through precision grinding, and Use a high-mesh sieve to sieve the ground powder. The Coptidis rhizome is also ground and sieved with a high-mesh sieve. The preservative is added in three times, and each addition is one-third of the total amount. One, the loxoprofen sodium, preservative, humectant, and antioxidant are initially mixed, and after the mixing is completed, an ethanol solution is added for stirring, and then powdered Coptis rhizome is added to the solution, a...

Embodiment 3

[0050] Embodiment three: a kind of gel of loxoprofen sodium, comprising 15 parts of loxoprofen sodium, 30 parts of gel substrate, 15 parts of preservatives, 20 parts of humectants, 80 parts of ethanol solution, 3 parts of antioxidants 15 parts of transdermal absorption accelerator, 10 parts of pH regulator, 10 parts of bacteriostatic agent, 10 parts of Coptidis rhizome, the addition amount of described pH regulator is determined according to the actual solution pH value, and described loxoprofen sodium should be through precision grinding, and Use a high-mesh sieve to sieve the ground powder. The Coptidis rhizome is also ground and sieved with a high-mesh sieve. The preservative is added in three times, and each addition is one-third of the total amount. One, the loxoprofen sodium, preservative, humectant, and antioxidant are initially mixed, and after the mixing is completed, an ethanol solution is added for stirring, and then powdered Coptis rhizome is added to the solution, ...

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PUM

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Abstract

The present invention relates to the technical field of pharmaceutical preparations, and discloses loxoprofen sodium gel. The loxoprofen sodium gel comprises 5 parts of loxoprofen sodium, 15 parts of a gel base material, 10 parts of a preservative, 30 parts of a humectant, 50 parts of an ethanol solution, 3 parts of an antioxidant, and 10 parts of a transdermal absorption enhancer; the gel base material is sodium alginate; the transdermal absorption enhancer is eucalyptus oil; and the concentration of the ethanol solution is 75%. According to the loxoprofen sodium gel and the preparation method thereof, the loxoprofen sodium is finely ground and is matched with the transdermal absorption enhancer, so that in the use process, on one hand, the transdermal absorption enhancer changes the permeability of the skin on the body surface of a human body, and the loxoprofen sodium can enter the human body more conveniently; and on the other hand, after loxoprofen sodium is ground into small-particle powder, the absorption process of the skin to the medicine is accelerated, the medicine can take effect more quickly, and the treatment progress is greatly accelerated.

Description

technical field [0001] The invention relates to the technical field of pharmaceutical preparations, in particular to a gel of loxoprofen sodium and a preparation method thereof. Background technique [0002] Loxoprofen sodium was first developed by Japan's Sankyo Co., Ltd., and now it is the first-selling variety of non-steroidal anti-inflammatory drugs in Japan. It has been recorded by the Japanese Pharmacopoeia, and China has imported it. This product has been included in the National Ninth Five-Year Plan and one of the recommended trial varieties for new product development in 2010. Compared with similar clinical drugs, loxoprofen sodium has the following characteristics: stronger (better clinical effect), faster (the plasma concentration reaches the peak within 30 minutes after oral administration), and safer (less side effects). The other feature is that it has a wide range of indications, and can be widely used clinically for anti-inflammatory and analgesic treatment ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/06A61K31/216A61K47/10A61K47/22A61K47/44A61K47/46A61P19/02A61P21/00A61P29/00
CPCA61K31/216A61K9/06A61K47/22A61K47/10A61K47/44A61K9/0014A61K47/46A61P29/00A61P19/02A61P21/00
Inventor 陈奕帆
Owner 河南上恒医药科技有限公司
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