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Preparation method of low polycyclic aromatic hydrocarbon icaritin

A technology of icariin and polycyclic aromatic hydrocarbons, which is applied in the preparation of sugar derivatives, chemical instruments and methods, sugar derivatives, etc., can solve the problems of environmental pollution, long time, low efficiency, etc., and achieve high transfer rate and production The effect of low cost and high raw material handling capacity

Pending Publication Date: 2021-09-07
劲牌持正堂药业有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] Icaritin is often prepared by acid hydrolysis or enzymatic hydrolysis of icariin, but acid hydrolysis pollutes the environment, while conventional enzymatic hydrolysis takes a long time and is inefficient

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] A kind of preparation method step of low polycyclic aromatic hydrocarbon icariin is as follows:

[0029] Extraction: Take 10Kg of chopped Epimedium raw material, add 20 times the volume of 30% ethanol for heating and reflux extraction, extract three times, each time for 1 hour, and combine the extracts.

[0030] Concentration for the first time: Concentrate the above-mentioned extract to 5 times of the original medicinal material with a vacuum concentrator.

[0031] Separation of macroporous resin: put the above concentrate on D101 macroporous resin column at a flow rate of 1BV / h, add 3 times of pure water to elute at a flow rate of 1BV / h, then add 4 times of 50% ethanol at a flow rate of 1BV / h The flow rate was eluted, and the ethanol eluate was collected.

[0032] Gel white ball column adsorption: the above macroporous resin ethanol eluent enters the gel white ball column in series for adsorption to remove polycyclic aromatic hydrocarbons, and collects the effluent. ...

Embodiment 2

[0040] A kind of preparation method step of low polycyclic aromatic hydrocarbon icariin is as follows:

[0041] Extraction: take 10Kg of chopped Epimedium raw material, add 15 times the volume of 50% ethanol for heating and reflux extraction, extract three times, each time for 2 hours, and combine the extracts.

[0042] Concentration for the first time: Concentrate the above-mentioned extract to 4 times of the original medicinal material with a vacuum concentrator.

[0043] Separation of macroporous resin: put the above concentrated solution on the AB-8 macroporous resin column at a flow rate of 2.5BV / h, add 7.5 times of pure water to elute at a flow rate of 1.5BV / h, then add 5 times of 60% ethanol to The flow rate of 2.5BV / h was eluted, and the ethanol eluate was collected.

[0044] Gel white ball column adsorption: the above macroporous resin ethanol eluent enters the gel white ball column in series for adsorption to remove polycyclic aromatic hydrocarbons, and collects the...

Embodiment 3

[0052] A kind of preparation method step of low polycyclic aromatic hydrocarbon icariin is as follows:

[0053] Extraction: Take 10Kg of the chopped Epimedium raw material, add 8 times the volume of 70% ethanol for heating and reflux extraction, extract three times, each time for 3 hours, and combine the extracts.

[0054] Concentration for the first time: Concentrate the above-mentioned extract to 2 times of the original medicinal material with a vacuum concentrator.

[0055] Separation of macroporous resin: put the above concentrate on LS300 macroporous resin column at a flow rate of 4BV / h, add 10 times of pure water to elute at a flow rate of 2BV / h, then add 6 times of 75% ethanol at a flow rate of 4BV / h The flow rate was eluted, and the ethanol eluate was collected.

[0056]Gel white ball column adsorption: the above macroporous resin ethanol eluent enters the gel white ball column in series for adsorption to remove polycyclic aromatic hydrocarbons, and collects the efflu...

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PUM

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Abstract

The invention relates to a preparation method of low-polycyclic aromatic hydrocarbon icaritin, and is characterized in that polycyclic aromatic hydrocarbon components in icaritin are fully removed through a gel white ball column, meanwhile, the icariin is hydrolyzed by an immobilized enzyme column, so that the operation process is more coherent, and meanwhile, the gel white ball column and the immobilized enzyme column do not adsorb effective components in the icaritin; and continuous utilization can be realized in production, a raw material handling capacity is high, loss of effective components in the production process is small, and a transfer rate is high.

Description

technical field [0001] The invention belongs to the field of preparation of plant extracts, in particular to a method for preparing icariin with low polycyclic aromatic hydrocarbons. Background technique [0002] Icaritin is the aglycone of icariin. Studies have shown that Epimedium has the functions of enhancing human immune function, delaying aging, and preventing neurological diseases. However, icariin, as the main active monomer component of epimedium, has only 12% oral bioavailability, and its mechanism is to play a therapeutic role after being transformed into icariin through metabolism. In recent years, the effects of icariin on anti-tumor, anti-fibrosis, anti-osteoporosis, neuroprotection, improvement of prostate function, immunosuppression, anti-inflammation, and anti-oxidation have been gradually discovered. In order to improve the bioavailability of epimedium, converting icariin into icariin, which is more easily absorbed by the human body, has become the researc...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C12P17/06C07D311/30C07D311/40C07H17/07C07H1/08
CPCC12P17/06C07D311/30C07D311/40C07H17/07C07H1/08
Inventor 胡力飞徐浪陈志元张继斌张露明孙代华
Owner 劲牌持正堂药业有限公司
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