Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Ephedra decoction standard substance and preparation method and quality detection method thereof

A quality detection method, the technology of Mahuang Decoction, applied in the direction of measuring devices, instruments, scientific instruments, etc., can solve the problems of loss, low efficiency of quality detection methods, and inability to fully reflect the key quality attributes of Mahuang Decoction

Active Publication Date: 2021-09-14
盛实百草药业有限公司 +1
View PDF5 Cites 2 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, the research on the substance standard of Mahuang Decoction is still in the process of exploration. Although some new preparation methods have been proposed, there are still many problems. Key quality attributes of decoctions; as another example, the quality detection method of Mahuang Decoction material benchmark has low efficiency and poor stability, and there is no relatively comprehensive and systematic quality evaluation system

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Ephedra decoction standard substance and preparation method and quality detection method thereof
  • Ephedra decoction standard substance and preparation method and quality detection method thereof
  • Ephedra decoction standard substance and preparation method and quality detection method thereof

Examples

Experimental program
Comparison scheme
Effect test

preparation example Construction

[0080] The invention provides a preparation method of Mahuang Decoction material benchmark, comprising the following steps:

[0081] Take 41.4 parts by weight of ephedra, add 1800 parts by volume of water, adjust the heating power of the electric pottery stove to 1500-2100W to boil, then adjust to 500-700W and cook for 20-30min, remove the foam, then add 27.6 parts by weight of cinnamon sticks, 27.6 parts by weight of dried bitter almonds and 13.8 parts by weight of licorice, continue to decoct at 500 to 700W for 30 to 60 minutes, filter, and add water to the obtained filtrate to constant volume, which is the material reference of Mahuang soup;

[0082] Wherein, the corresponding relationship between parts by weight and parts by volume is g / mL.

[0083] "Classical formula material benchmark" refers to the benchmark of traditional Chinese medicine medicinal substances prepared on the basis of the ancient classical formula preparation methods recorded in ancient books. Except fo...

Embodiment 1

[0154] The preparation of embodiment 1 Mahuang Decoction material benchmark

[0155] Weigh 41.4g of ephedra and put it in a casserole, add 1800mL of water, adjust the heating power of the electric pottery stove to 1500W, heat the system to a boiling state, and take 12min from room temperature to boiling; then adjust the heating power to 600W, decoct for 25min, at this time The evaporation of water is 400mL, and the foam is skimmed with a small spoon; then 27.6g of cinnamon sticks, 27.6g of bitter almonds and 13.8g of licorice are added, continue to cook at 600W for 45min, and filter through a 200-mesh sieve to obtain about 450mL of filtrate. , add water to make the volume to 500mL, which is the material standard of Mahuang Decoction.

[0156] Among them, the above-mentioned four medicinal materials of ephedra, cinnamon stick, bitter almond and Zhigancao respectively correspond to the batch numbers in Table 1: H170183001-3, S174560S01, H180119001-3 and H170001002.

Embodiment 2

[0157] The preparation of embodiment 2 Mahuang Decoction material benchmark

[0158] Weigh 41.4g of ephedra and put it in a casserole, add 1800mL of water, adjust the heating power of the electric pottery stove to 1500W, heat the system to a boiling state, and take 12min from room temperature to boiling; then adjust the heating power to 700W, decoct for 22min, at this time The evaporation of water is 400mL, and the foam is skimmed with a small spoon; then 27.6g of cinnamon sticks, 27.6g of bitter almonds, and 13.8g of licorice are added, continue to cook at 700W for 37min, and filter through a 200-mesh sieve to obtain about 470mL of filtrate. , add water to make the volume to 500mL, which is the material standard of Mahuang Decoction.

[0159] Among them, the above-mentioned four medicinal materials of ephedra, cinnamon stick, bitter almond and Zhigancao respectively correspond to the batch numbers in Table 1: H170182001-3, S174440S01, H180011001-3 and H180160002-3.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

PropertyMeasurementUnit
lengthaaaaaaaaaa
particle diameteraaaaaaaaaa
Login to View More

Abstract

The invention belongs to the field of Chinese herbal medicine quality control, and particularly relates to an ephedrae decoction standard substance and a preparation method and a quality detection method thereof. According to the preparation method of the ephedra decoction standard substance, freeze-dried powder preparation is changed into standard decoction preparation, operations such as concentration and drying are not needed, and volatilization of some important components (such as cinnamaldehyde) is avoided. Based on the ephedra decoction standard substance prepared by the method, the original taste and flavor of the 'one bowl' of ancient prescription ephedra decoction can be restored. The method can be used for guiding actual industrial production. According to the ephedra decoction standard substance quality detection method, quantitative determination of ephedrine hydrochloride, pseudoephedrine hydrochloride and amygdalin and qualitative analysis of liquiritin, cinnamic acid, cinnamaldehyde and glycyrrhizic acid are fused, meanwhile, new chromatographic conditions are developed, the separation degree is better, the stability is better, the detection time is short, and the efficiency is high.

Description

technical field [0001] The invention belongs to the field of quality control of Chinese herbal medicines, and particularly relates to a substance reference of Mahuang decoction, a preparation method and a quality detection method thereof. Background technique [0002] The classic prescription is still widely used due to its definite curative effect. In order to support the development of classic prescriptions, the State Drug Administration issued the "Administrative Regulations on Simplified Registration and Approval of Traditional Chinese Medicine Compounds with Ancient Classical Famous Prescriptions" in May 2018. There are two stages of preparation development. The applicant shall develop the "Classic Named Prescription Substance Benchmark" in accordance with the prescriptions and preparation methods published in the catalogue of ancient classical famous prescriptions, and conduct research on the preparation of the classic famous prescription according to the "Classic Name...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(China)
IPC IPC(8): G01N30/02G01N30/34G01N30/74G01N30/06G01N30/14G01N30/86
CPCG01N30/02G01N30/34G01N30/74G01N30/06G01N30/14G01N30/8634G01N30/8679Y02A50/30
Inventor 刘艳刘安邸继鹏张国媛严桂林曹丽娟杨林勇姜恒丽王双双马向慧
Owner 盛实百草药业有限公司
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com