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A high-efficiency liquid bandage

A liquid band-aid, high-efficiency technology, applied in non-active ingredients medical preparations, medical preparations containing active ingredients, drug combinations, etc. It can improve the transdermal diffusion efficiency and the absorption rate of the human body, improve the flexibility, and protect the wound surface.

Active Publication Date: 2022-05-03
HUNAN TIANXIANG BIOTECHNOLOGY CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] However, there are obvious defects in the traditional wound dressing during use: poor air permeability; All have a certain size, and it is inconvenient to use for some specific wound parts, etc.
[0005] At present, the domestic liquid bandage-related industry is still in its infancy. Although there are related sporadic products launched, there are many problems such as strong skin irritation, long film-forming time, and poor waterproofness.

Method used

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  • A high-efficiency liquid bandage
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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] A high-efficiency liquid bandage, consisting of the following raw materials in parts by weight:

[0032] Modified nitrocellulose-acrylic resin polymer powder 25g, propolis 1g, polyvinyl alcohol 2g, cetearyl alcohol 0.05g, sodium pyrrolidone carboxylate 0.01g, propylene glycol and acetyl tributyl citrate by mass ratio 1: 1 Mixed plasticizer 0.01g, monolauryl phosphate 0.01g, laurocapram 0.05g, borneol 0.15g, benzalkonium chloride 0.03g, ethanol 40g, deionized water 8g.

[0033] Wherein, the preparation method of modified nitrocellulose-acrylic resin polymer powder is as follows:

[0034] Add modified nitrocellulose to a mixed solution composed of ethanol and DMSO at a volume ratio of 10:1, stir well and then raise the temperature to 50°C, add sodium dodecylbenzenesulfonate and OP-10, stir and react for 3 hours to obtain Modified nitrocellulose pre-emulsion, adding a mixed monomer composed of butyl acrylate and methyl methacrylate at a mass ratio of 5:1 to the modified n...

Embodiment 2

[0038] A high-efficiency liquid bandage, consisting of the following raw materials in parts by weight:

[0039] Modified nitrocellulose-acrylic resin polymer powder 20g, propolis 3g, polyvinyl alcohol 2g, cetearyl alcohol 0.01g, sodium pyrrolidone carboxylate 0.1g, propylene glycol and acetyl tributyl citrate by mass ratio 1: 1 Mixed plasticizer 0.01g, monolauryl phosphate 0.02g, laurocapram 0.05g, borneol 0.12g, benzalkonium chloride 0.01g, ethanol 40g, deionized water 5g.

[0040] Wherein, the preparation method of modified nitrocellulose-acrylic resin polymer powder is as follows:

[0041] Add the modified nitrocellulose to the mixed solution composed of ethanol and DMSO with a volume ratio of 10:1, stir well and then raise the temperature to 60°C, add sodium dodecylbenzenesulfonate and OP-10, and stir for 2 hours to obtain Modified nitrocellulose pre-emulsion, adding a mixed monomer composed of butyl acrylate and methyl methacrylate at a mass ratio of 2:1 to the modified ...

Embodiment 3

[0045] A high-efficiency liquid bandage, consisting of the following raw materials in parts by weight:

[0046] Modified nitrocellulose-acrylic resin polymer powder 20g, propolis 1g, polyvinyl alcohol 1g, cetearyl alcohol 0.01g, sodium pyrrolidone carboxylate 0.01g, propylene glycol and acetyl tributyl citrate by mass ratio 1: 1 Mixed plasticizer 0.01g, monolauryl phosphate 0.01g, laurocapram 0.05g, borneol 0.1g, benzalkonium chloride 0.01g, ethanol 40g, deionized water 5g.

[0047] Wherein, the preparation method of modified nitrocellulose-acrylic resin polymer powder is as follows:

[0048] Add modified nitrocellulose to a mixed solution composed of ethanol and DMSO at a volume ratio of 10:1, stir well and then raise the temperature to 50°C, add sodium dodecylbenzene sulfonate and OP-10, stir and react for 2 hours to obtain Modified nitrocellulose pre-emulsion, adding a mixed monomer composed of butyl acrylate and methyl methacrylate at a mass ratio of 1:1 to the modified n...

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Abstract

The invention relates to the field of external medicaments, specifically a high-efficiency liquid wound dressing, which consists of the following raw materials in parts by weight: 20-30 parts of modified nitrocellulose-acrylic resin polymer powder, 1-3 parts of propolis, polyvinyl alcohol 1‑3 parts, 0.01‑0.1 part of cetearyl alcohol, 0.01‑0.1 part of sodium pyrrolidone carboxylate, 0.01‑0.1 part of plasticizer, 0.01‑0.1 part of monolauryl phosphate, 0.05‑0.1 part of laurocaprolactone , 0.1-0.2 part of borneol, 0.01-0.1 part of pharmaceutical active ingredient, 30-40 part of ethanol, 5-10 part of deionized water, the film layer formed by the liquid wound dressing prepared by the present invention is applied on the skin is smooth, and the skin paste Good fit, good film-forming properties, air permeability and water resistance.

Description

technical field [0001] The invention relates to the field of external medicaments, in particular to a high-efficiency liquid wound dressing. Background technique [0002] At present, the traditional bandage is a long-shaped adhesive plaster with gauze soaked in medicine in the middle, which is used to stick on the wound to protect the wound, temporarily stop bleeding, resist bacterial regeneration, and prevent the wound from being damaged again. , The most commonly used emergency medical supplies in the family. [0003] However, there are obvious defects in the traditional wound dressing during use: poor air permeability; All have a certain size, and it is inconvenient to use for some specific wound sites. [0004] As a new type of medical wet dressing, liquid wound dressing is mainly made of raw materials such as biocompatible polyurethane PU film, volatile alcohol or ethyl acetate solution, benzalkonium chloride, etc., which can dry quickly and form a breathable, The wa...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/70A61K45/00A61K47/10A61K47/22A61K47/38A61P17/02C08F251/00C08F220/18C08F220/14
CPCA61K9/7007A61K47/38A61K47/22A61K47/10A61K45/00A61P17/02C08F251/00C08F220/1804C08F220/14
Inventor 黄名勇
Owner HUNAN TIANXIANG BIOTECHNOLOGY CO LTD