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Inhibiting or alleviating agent for inflammation in the brain

A preparation, brain technology, applied in the field of brain inflammation suppression or relief preparations, can solve problems such as memory impairment and neuroinflammation treatment potential that have not been evaluated

Pending Publication Date: 2021-09-21
刘军 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the therapeutic potential of NTP in terms of memory impairment and neuroinflammation during AD has not been evaluated

Method used

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  • Inhibiting or alleviating agent for inflammation in the brain
  • Inhibiting or alleviating agent for inflammation in the brain
  • Inhibiting or alleviating agent for inflammation in the brain

Examples

Experimental program
Comparison scheme
Effect test

Embodiment

[0046] For the basic extraction steps of extracts, for example, the following steps are used.

[0047] (A) Collect inflamed skin tissues of rabbits and mice inoculated with vaccinia virus intradermally, and crush the inflamed tissues. The extraction process is performed for several days by adding an extraction solvent such as water, phenol water, physiological saline, or phenol-added glycerol water to the disrupted tissue. Then, the mixture is filtered or centrifuged to obtain a crude extract (filtrate or supernatant), from which tissue fragments are removed.

[0048] (B) Adjust the crude extract obtained in (A) to an acidic pH value, heat, then filter or centrifuge for protein removal. Thereafter, the deproteinized solution is adjusted to alkaline pH, heated, and then filtered or centrifuged to obtain a deproteinized filtrate or supernatant.

[0049] (C) Adjust the filtrate or supernatant obtained in (B) to an acidic pH value, and adsorb with an adsorbent such as activated ...

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Abstract

An inhibiting or alleviating agent for inflammation in the brain comprising an extract from inflamed tissue inoculated with vaccinia virus as the active ingredient. A determination or evaluation method of an extract from inflamed tissue inoculated with vaccinia virus or an agent comprising the extract, characterized in that the inhibition of the expression of pro-inflammatory cytokines and / or NF-kB pathway related proteins induced by the promotion of expression of BDNF in cultivated glial cells is used as an indicator. A use of an extract from inflamed tissue inoculated with vaccinia virus in the production of the inhibiting or alleviating agent for inflammation in the brain.

Description

technical field [0001] The present invention relates to a preparation for suppressing or alleviating brain inflammation comprising an extract derived from inflamed tissue inoculated with vaccinia virus (hereinafter sometimes referred to as "extract"). Background technique [0002] Alzheimer's disease (AD) is the most common cause of dementia, affecting one in ten people over the age of 65. AD typically results in the extracellular accumulation of amyloid beta (Aβ), forming plaques. There is compelling evidence that Aβ binds to inflammatory receptors such as TNFR1 and IL-1R and activates inflammation during AD. Immune-related receptors play an important role in learning and memory formation, and excessive neuroinflammation can lead to immediate cognitive impairment. Importantly, synaptic pruning can be regulated by inflammatory signals, and chronic neuroinflammation leads to loss of synapse-associated proteins. Furthermore, microglia have been reported to cause synaptic pr...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N33/68C12Q1/00
CPCG01N33/6896G01N2800/2821G01N33/5023G01N33/5041G01N33/5058G01N33/6863A61K35/36A61K35/76A61P25/28A61P25/00C12Q1/00G01N33/68A61K35/30C12N5/0622C12N2502/70
Inventor 刘军廖旺方文丽范胜诺郑雨秋
Owner 刘军
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