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Repair of uv-induced DNA lesions

A composition and technology of photolytic enzymes, applied in the field of DNA damage repair, can solve problems such as increased interest in cryptochrome, achieve reduction of actinic keratosis lesions and/or non-melanoma skin cancer, prevent or reduce photo Carcinogenesis and the effect of reducing carcinogenesis in subclinical regions

Active Publication Date: 2021-09-28
阿斯特里昂治疗学有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, since these pigments may constitute primary circadian photoreceptors in mammals and other organisms, there has been a sharp rise in interest in cryptochromes

Method used

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  • Repair of uv-induced DNA lesions
  • Repair of uv-induced DNA lesions
  • Repair of uv-induced DNA lesions

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Embodiment Construction

[0078] The present invention will be described with respect to specific embodiments and with reference to certain drawings but the invention is not limited thereto but only by the claims. The drawings described are illustrative only and non-limiting. In the drawings, the size of some of the elements may be exaggerated and not drawn on scale for illustrative purposes. The dimensions and relative dimensions do not correspond to actual reductions in the practice of the invention.

[0079] Furthermore, the terms first, second, etc. in the description and claims are used to distinguish similar elements, and not necessarily to describe an order in time, space, hierarchical order or in any other way. It is to be understood that the terms so used are interchangeable under appropriate circumstances and that the described embodiments of the invention are capable of operation in other sequences than described or illustrated herein.

[0080] It should be noted that the term "comprising"...

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Abstract

A composition comprising a recombinant enzyme that comprises a fusion of: a cyclobutane pyrimidine dimer photolyase corresponding to an amino acid encoding sequence having at least 85% sequence identity to SEQ ID NO 1, a pyrimidine(6-4)pyrimidone photolyase corresponding to an amino acid encoding sequence having at least 85% sequence identity to SEQ ID NO 2, and a skin penetrating peptide.

Description

[0001] field of invention [0002] The present invention relates to the field of repair of DNA damage, eg damage due to UV radiation, for eg skin protection or dermatological treatment. More particularly, it relates to compositions, nucleic acid molecules and nucleic acid vectors. Background technique [0003] Deoxyribonucleic acid (DNA) is the basic substance of life and changes during long-term evolution, but the strict homeostasis of DNA is very important for maintaining individual organisms in the short term. DNA damage is believed to occur in each cell at a rate of tens of thousands of events per day as cells perform essential activities, such as normal metabolic processes, such as endogenous DNA damage, originating from replication errors and oxidative damage. External factors, such as ultraviolet (UV), ionizing radiation, and environmental mutagens (such as tobacco smoke, exhaust fumes, etc.) can also cause DNA damage. [0004] Chronic overexposure to ultraviolet (UV)...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07K14/195C12N9/88
CPCC12N9/88C12Y401/99003C07K2319/21C07K2319/33A61K8/66A61K38/51A61Q19/08C07K14/47C12N15/8257
Inventor J·霍芬克
Owner 阿斯特里昂治疗学有限公司