Amyloid precursor protein as a diagnostic marker for biliary atresia

A technique for biliary atresia, amyloid, applied in assessing the likelihood of adverse outcomes in infants, diagnosing biliary atresia or assessing risk areas for biliary atresia, capable of addressing issues such as failure

Pending Publication Date: 2021-10-01
VERSITECH LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

The procedure usually has a 65-85% success rate, but still results in failure in a small percentage of babies who may then require a liver transplant for long-term survival

Method used

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  • Amyloid precursor protein as a diagnostic marker for biliary atresia
  • Amyloid precursor protein as a diagnostic marker for biliary atresia
  • Amyloid precursor protein as a diagnostic marker for biliary atresia

Examples

Experimental program
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Embodiment 1

[0091] Example 1: Expression of amyloid precursor protein in biliary atresia

[0092] This study reveals for the first time the specific expression of amyloid precursor protein and / or its processed form in the bile ducts of the liver of patients with biliary atresia (BA). This finding enables the design of new and reliable diagnostic methods for the early detection of BA as well as for predicting the outcome of BA treatments (eg, Kasai procedure).

[0093] introduce

[0094] Biliary atresia (BA [OMIM 210500]) is characterized by progressive fibro-obliterative cholangiopathy (disease of the bile ducts) affecting the intrahepatic and extrahepatic bile ducts and leading to obstruction of bile flow, cholestasis, and neonatal jaundice. Some infants develop BA between 2 and 6 weeks after birth. Symptoms of BA usually manifest between 2 and 6 weeks after birth because infants with BA develop progressive cholestasis, a condition in which the liver fails to excrete biliary red as bile...

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Abstract

Provided are novel diagnostic and prognostic methods for biliary atresia using amyloid precursor protein.

Description

[0001] Background of the invention [0002] Biliary atresia is a disease of the liver and bile ducts that occurs in infants. Typically, symptoms of biliary atresia appear or develop around 2 weeks to 8 weeks after birth. Cells in the liver produce bile, a digestive juice that helps digest fats. It also transports waste from the liver to the intestines for excretion. This network of channels and tubes that produce bile, digest fat, and eventually travel to the intestine is called the biliary system. Under normal physiological conditions, the biliary system allows bile to drain from the liver into the intestine. However, when a baby has biliary atresia, it blocks the flow of bile from the liver to the gallbladder. This causes bile to become trapped in the liver, which can quickly damage and scar the liver cells, leading to cirrhosis and eventually liver failure. [0003] Although the exact cause of biliary atresia is not fully understood, it is believed that some babies devel...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C12Q1/6883G01N33/68
CPCC12Q1/6883C12Q2600/158G01N2800/085G01N2333/4709G01N33/6893G01N2333/705
Inventor 吕志恒R.奥塔坎达蒂尔巴布P.K.H.谭
Owner VERSITECH LTD
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