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Application of fructus gardeniae and cortex platycladi decoction in preparation of medicine for treating acute gouty arthritis

A technology of Zhizibaipi decoction and acute gout, which is applied in the field of traditional Chinese medicine compound preparations to achieve the effects of promoting expression, obvious inhibitory effect, improving the swelling state of ankle joints and abnormal gait.

Inactive Publication Date: 2021-10-29
GUANGDONG PHARMA UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, there is no research report on the use of Zhizi Baipi Decoction in the treatment of acute gouty arthritis.

Method used

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  • Application of fructus gardeniae and cortex platycladi decoction in preparation of medicine for treating acute gouty arthritis
  • Application of fructus gardeniae and cortex platycladi decoction in preparation of medicine for treating acute gouty arthritis
  • Application of fructus gardeniae and cortex platycladi decoction in preparation of medicine for treating acute gouty arthritis

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0016] Embodiment 1: Anti-acute gouty arthritis experiment of Zhizi Baipi Decoction (GP)

[0017] 1.1 Experimental equipment and materials

[0018] 1.1.1 Experimental animals

[0019] Several male C57BL / 6 mice, aged 5 weeks, weighing 22±2g. Purchased from Guangdong Medical Animal Center, certificate number: 44007260091211, adaptive feeding for one week.

[0020] 1.1.2 Experimental equipment and experimental reagents (Table 1-2):

[0021] Table 1. Experimental equipment

[0022]

[0023]

[0024] Table 2. Reagent materials

[0025]

[0026] 1.2 Experimental operation and steps

[0027] 1.2.1 Prepare relevant experimental materials: normal saline, vaseline, syringe, capillary, etc.

[0028] 1.2.2 Preparation of related reagents:

[0029] (1) Preparation of microcrystalline sodium urate: Add about 4 g of uric acid into 800 mL of distilled water containing NaOH (9 mL / 0.5 N) and heat until the uric acid dissolves, adjust the pH to 8.9 at 60 ° C, and stir slowly with...

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Abstract

The invention discloses application of a fructus gardeniae and cortex platycladi decoction in preparation of a medicine for treating acute gouty arthritis and provides a new medicine choice for the acute gouty arthritis. Pharmacodynamic research shows that the fructus gardeniae and cortex platycladi decoction has an obvious inhibiting effect on inflammation and swelling of the acute gouty arthritis, has no acute toxicity on mice after short-time administration, can be further developed into the medicine for resisting the acute gouty arthritis, and has a clinical application prospect and a very high economic utilization value.

Description

technical field [0001] The invention relates to a new application of a traditional Chinese medicine compound preparation, in particular to the application of Zhizi Baipi Decoction in the preparation of medicine for treating acute gouty arthritis. Background technique [0002] Acute gouty arthritis is the disorder of purine metabolism or the decrease of uric acid excretion, which leads to the deposition of uric acid in the joint capsule, synovial bursa, cartilage, and bone, which causes obvious redness, swelling and pain in the soft tissue around the joint. The local area cannot bear the quilt or the surrounding vibration. Waking up with pain, an acute inflammatory reaction that hurts like a knife. [0003] The current treatment for acute gouty arthritis is mainly oral medication, commonly used drugs include non-steroidal anti-inflammatory drugs, colchicine, glucocorticoids and so on. It is generally believed that colchicine is the drug of choice for the treatment of acute g...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/756A61P19/02A61P19/06A61P29/00
CPCA61K36/744A61K36/756A61K36/484A61P19/02A61P19/06A61P29/00A61K2300/00
Inventor 王治平王一飞杜康
Owner GUANGDONG PHARMA UNIV
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