Andrographolide and application thereof

A technology of andrographolide and andrographis paniculata, applied in the field of biomedicine, to achieve the effect of improving gum bleeding symptoms, improving gum inflammation, and excellent anti-inflammatory effects

Pending Publication Date: 2021-11-05
广西天方医药有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] Furthermore, for oral care products, in addition to considerations such as safety and effectiveness, factors such as mouthfeel, taste, and smell are closely related to consumers’ acceptance of t

Method used

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  • Andrographolide and application thereof
  • Andrographolide and application thereof
  • Andrographolide and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Example Embodiment

[0043] Example 1, the preparation of the present invention

[0044] Take the heart lotus medicine, adding the amount of medicinal material 6 times 80% ethanol, stir uniform, soothe, soothe extraction 3 times, 8 hours each time. After filtration, the cold impurities were filtered, concentrated to a relative density of 1.02, and the concentrate was allowed to stand for 12 hours or more crystallization, filtered to give a crude crystal. The amount of 95% ethanol was added to the crude crystal, and the stirring was completely dissolved, filtered, and the inner lane alcohol solution was obtained. The pendant lactone alcohol solution was allowed to concentrate 12 hours or higher than the crystalline, the crystal was filtered, and the crystalline was dried at 60 ° C for 8 hours to obtain a dry matter, and the dried material was divided into fine powder by 100 mesh sieve, which was to be worn in the fluorene. The rate was 3.15%, purity 98.46%.

Example Embodiment

[0045] Example 2, the preparation of the present invention

[0046] Take the heart lotus medicinal material, adding the amount of medicinal material 6 times 75% ethanol, stir well and submersible for 2 times, 8 hours each time. After filtration, the cold impurities were filtered, concentrated under reduced pressure to 1.04, and the concentrate was allowed to stand for 12 hours to crystallize, filtered to give a crude crystal. The amount of 95% ethanol was added to the crude crystal, and the stirring was completely dissolved, filtered, and the inner lane alcohol solution was obtained. The pendide carolide alcohol solution was allowed to concentrate 12 hours, and the crystals were collected, and the crystals were dried at 60 ° C for 8 hours to obtain a dry matter, and the dried material was divided into fine powder to be divided into 100 mesh sieves.

Example Embodiment

[0047] Example 3, the preparation of the inventive lanes

[0048] Take the heart lotus medicinal material, add 8 times 85% ethanol, stir well, and then submergerated 4 times, 10 hours each time. After filtration, the cold impurities were filtered, concentrated to a relative density of 1.08, and the concentrate was allowed to stand for 12 hours to crystallize, filtered to give a crude crystal. The amount of 95% ethanol was added to the crude crystal, and the stirring was completely dissolved, filtered, and the inner lane alcohol solution was obtained. The pendide carolide alcohol solution was allowed to concentrate 12 hours, and the crystals were collected, and the crystals were dried at 60 ° C for 8 hours to obtain a dry matter, and the dried material was divided into fine powder to be divided into 100 mesh sieves.

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Abstract

The invention provides application of andrographolide in preparation of antiallergic oral care products or medicines. The invention also provides andrographolide and a preparation method thereof, and an anti-inflammatory and/or antiallergic oral care product or medicine containing andrographolide. The andrographolide has excellent anti-inflammatory effect; and the oral care product using andrographolide as the active component can improve the symptoms of gingival inflammation, pain and redness and improve the symptoms of gingival bleeding, implements excellent anti-inflammatory and antiallergic effects in a short time, and has favorable application prospects.

Description

technical field [0001] The invention belongs to the field of biomedicine, and in particular relates to andrographolide and its application. Background technique [0002] In daily life, people often experience numbness and pain in teeth when exposed to cold, heat, acid, and sweetness. This is often called tooth sensitivity. caused by exposure. Under external stimuli, the conduction of the cytoplasmic protrusions of the dentin cells causes sensitivity symptoms, and changes in the blood circulation of the dental pulp, such as enamel trauma, hyperemia at the root tip of the tooth, and other factors may cause sensitivity symptoms. With age, the teeth become more sensitive. The frequency is more prominent, seriously affecting people's quality of life. Dental inflammations such as periodontitis, oral ulcers and enamel trauma are also common diseases of teeth. Oral inflammation and tooth sensitivity all affect people's normal life. [0003] In order to prevent or alleviate the ab...

Claims

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Application Information

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IPC IPC(8): A61K31/365A61P1/02A61P37/08A61K8/49A61Q11/00C07D307/60A61K36/19
CPCA61K31/365A61P1/02A61P37/08A61K8/4973A61Q11/00C07D307/60A61K2236/331A61K2236/39A61K2236/53A61K2236/51A61K2800/28A61K36/19
Inventor 尹大鹏
Owner 广西天方医药有限公司
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