A multi-color imaging system based on holographic optics and holographic optical tweezers device
A technology of optical tweezers and holography, applied in the field of light, can solve the problems of limited capabilities of multi-wavelength fluorescence imaging systems
Active Publication Date: 2022-03-25
广州市凯佳光学科技有限公司
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[0004] The embodiment of the present application provides a multi-color imaging system and holographic optical tweezers device based on holographic optics, to at least solve the problem of limited capabilities of microscope-based optical tweezers systems and multi-wavelength fluorescence imaging systems in the prior art
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[0021] It should be noted that, in the case of no conflict, the embodiments in the present application and the features in the embodiments can be combined with each other. The present application will be described in detail below with reference to the accompanying drawings and embodiments.
[0022] In this embodiment, a holographic optical tweezers device combined with multi-color fluorescence microscopy imaging is provided, including: a laser 1, used to emit laser light for capturing particles; a polarization modulation unit, used to modulate the polarization state of the laser light emitted by the laser , to control the laser intensity; the spatial light modulator 6 is used to modulate the light field of the light from the polarization modulation part, wherein the modulated light field is tightly focused by the first microscopic objective lens to form optical tweezers.
[0023] Through the above device, optical tweezers formed by holographic light can be produced, which solv...
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This application discloses a multi-color imaging system based on holographic optics and a holographic optical tweezers device, including: a laser for emitting laser light for light capture; a polarization modulation unit for modulating the polarization state of the laser light emitted by the laser to realize the control of laser intensity The spatial light modulator is used to modulate the light field of the light from the polarization modulation part, and the modulated light field is tightly focused by the objective lens to form optical tweezers. The system includes: multi-wavelength optical modules are used to excite dyes of different wavelength bands, and perform multi-color imaging and tracking of samples; microscopes, platforms for magnifying and observing samples; image acquisition modules are used for optical moment analysis and multi-color fluorescence imaging; control terminals are used for Control the holographic optical tweezers module, read the imaging information of the image acquisition module and control the electromechanical shutter in the microscope. This application solves the problem of the limited capability of the optical tweezers system in microscopic imaging, uses holographic optical tweezers to capture and move samples, and performs multi-dimensional structure and dynamic analysis of samples.
Description
technical field [0001] The present application relates to the optical field, in particular, to a multicolor imaging system based on holographic optics and a holographic optical tweezers device. Background technique [0002] Optical tweezers, that is, single-beam gradient force optical traps, are potential wells formed based on the interaction of scattering force and radiation pressure gradient force, which can capture particles in the entire Mie and Rayleigh scattering range. Gradient force plays a role in trapping particles, and the axial gradient force must overcome the scattering force if the particles are to be stably bound in the optical field potential well. Therefore, it is usually necessary to use a microscope objective lens with a large numerical aperture to highly converge the laser beam, so as to generate a strong enough gradient force to achieve particle capture. In the fields of soft matter, life science and biomedicine, optical tweezers technology can be combi...
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IPC IPC(8): G02B21/32G02B21/00G02B21/36G02B27/28G02F1/01G02F1/09G21K1/00
CPCG02B21/32G21K1/00G02F1/0136G02F1/093G02B27/286G02B27/283G02B21/0076G02B21/361
Inventor 娄凯温维佳
Owner 广州市凯佳光学科技有限公司