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Preparation method of SERS enhanced substrate based on electric replacement reaction

A technology of electro-displacement and substrate, which is applied in the field of preparation of SERS-enhanced substrate, which can solve the problems of time-consuming, labor-intensive and cost-increasing

Active Publication Date: 2021-11-30
DONGGUAN UNIV OF TECH
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  • Abstract
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  • Claims
  • Application Information

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Problems solved by technology

The optimization of the preparation conditions in the SERS preparation methods reported in the literature has certain shortcomings, that is, when the material is fixed, the size of the reinforcing element is often optimized first, and then the spacing between the reinforcing elements is optimized, or both are optimized at the same time.
No matter what kind of optimization method, on the one hand, the optimized parameters are relatively few, which are not necessarily close to the "best state" under the current experimental conditions; on the other hand, this optimization method is time-consuming and laborious, and also increases the cost

Method used

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  • Preparation method of SERS enhanced substrate based on electric replacement reaction
  • Preparation method of SERS enhanced substrate based on electric replacement reaction
  • Preparation method of SERS enhanced substrate based on electric replacement reaction

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preparation example Construction

[0031] A method for preparing a SERS-enhanced substrate based on an electric displacement reaction, comprising the steps of:

[0032] a. Preparation of metal or metal oxide sacrificial templates;

[0033] b. The sacrificial template in step a performs an electrodisplacement reaction with the metal salt solution solution of a metal with a better SERS enhancement effect, and the molecule to be studied or the probe molecule is added to the reaction solution at the same time. During the electrodisplacement reaction, real-time The SERS signal of the system is detected, so as to obtain the relationship diagram between the SERS signal and the electrodisplacement reaction time; according to this relationship diagram, the optimal preparation conditions of the SERS substrate in this experimental scheme can be known.

[0034] Further, in the step a, the selection condition of the metal or metal oxide sacrificial template material is: the selected sacrificial template material can be repl...

Embodiment 1

[0050] Electrodeposited cuprous oxide / titanium sheet (Cu 2 O / Ti) preparation of the sacrificial template: the polished and cleaned titanium sheet was used as the working electrode, the platinum sheet was used as the auxiliary electrode, and the saturated calomel electrode (SCE) was used as the reference electrode, and the prepared 10mM copper trifluoroacetate and an aqueous solution of 0.2M potassium trifluoroacetate by v:v=1:1 as the reaction electrolyte; the deposition potential is set to -0.06V, and the deposition time is 3600 seconds; after the preparation is completed, it is repeatedly washed with deionized water until it is clean, to obtain Cu with cuprous oxide particles with a diameter of 400-500nm on the surface 2 O / Ti sacrificial template, Cu 2 The shape and size of O can be found in figure 1 .

Embodiment 2

[0052] With Cu prepared in Example 1 2 O / Ti was used as a sacrificial template, 1mmol / L crystal violet (CV) solution was used as probe molecule mother solution, and 1mmol / L HAuCl 4 The solution is a noble metal replacement solution.

[0053] On-device step Cu 2 O / Ti sacrificial template, quickly add 0.1mL 1mmol / L CV solution, 9.9mL 1mmol / L HAuCl to the spectroelectrochemical cell 4 Solution, and mix; start timing and detect SERS signal at the same time, SERS signal from weak to strong and then weak. About 1000s into the experiment, several strong SERS peaks have dropped to less than a quarter of the strongest (reaction about 500s). To be on the safe side, in this example, the experiment was carried out for a total of 3200s, and the SERS with different reaction times Figure, such as figure 2 shown.

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Abstract

The invention relates to the technical field of surface enhanced Raman spectroscopy, in particular to a preparation method of an SERS enhanced substrate based on an electric replacement reaction, which comprises the following steps of carrying out electric replacement reaction on metal salt of metal with a better enhancement effect on Raman spectroscopy and a sacrificial template, and simultaneously adding molecules to be researched or probe molecules into a reaction solution, in the electric replacement reaction process, detecting the SERS signal of the system in real time, so that a relational graph of the SERS signal and the electric replacement reaction time is obtained. According to the relational graph, the optimal experiment condition of the SERS substrate in the experiment scheme can be known. The invention provides a preparation method which is based on an electric replacement reaction and can be used for simply and conveniently obtaining an optimal SERS enhanced substrate under corresponding experimental conditions with low cost and high efficiency.

Description

technical field [0001] The invention relates to the technical field of surface-enhanced Raman spectroscopy, in particular to a method for preparing a SERS-enhanced substrate based on an electrical displacement reaction. Background technique [0002] Surface-enhanced Raman scattering (SERS) has the advantages of high sensitivity, fast detection speed, and non-destructive detection of samples. The preparation of SERS-enhanced substrate is the key to this technology, and the quality of the enhanced substrate directly affects important performance indicators such as detection sensitivity and reproducibility. The SERS signal is related to factors such as the material of the reinforcing substrate, the size of the reinforcing elements (such as particles) on the surface of the substrate, and the spacing between the reinforcing elements. The optimization of the preparation conditions in the SERS preparation methods reported in the literature has certain shortcomings, that is, when t...

Claims

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Application Information

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IPC IPC(8): G01N21/01G01N21/65
CPCG01N21/01G01N21/658
Inventor 柳鹏
Owner DONGGUAN UNIV OF TECH
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