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Probes, systems, cartridges, and methods of use thereof

A technology of probes and porous materials, applied in the field of probes, systems, boxes and their use, can solve problems affecting the performance of probes, incompatibility, etc.

Pending Publication Date: 2021-11-30
PURDUE RES FOUND INC +3
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Also, the sharp tip of the paper nebulizer probe directly affects the performance of the probe, and mass production processes such as die-cutting used to manufacture paper substrates have incompatibility issues with sharp tips made of paper

Method used

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  • Probes, systems, cartridges, and methods of use thereof
  • Probes, systems, cartridges, and methods of use thereof
  • Probes, systems, cartridges, and methods of use thereof

Examples

Experimental program
Comparison scheme
Effect test

example 1

[0060] Example 1: Method

[0061] All chemicals were purchased from Sigma-Aldrich (Saint Louis (St.Louis, Mo, USA), Missouri, USA). Buffali Researry (INNOVATIVE RESECH) (Novi, Novi, Mi, USA), USA). Chromatography (Level 1 and Et31) used to make paper substrates were purchased from PayTM (WHATMAN INTERNATIONAL LTD). The molten silica catheter (O.D.130 μm, i.d.50 μm) for paper capillary sprayers (Molex Inc.) (Lisle, IL, USA), Illinois (Lisle, IL, USA). Using a QTRAP 4000 mass spectrometer equipped with a normal pressure interface (Applied Biosystems, Toronto, CA), using curtain gases and domestic miniature mass spectrometry with mini-pressure interface 12 Perform ms analysis.

[0062]For the paper sprayer, the spray substrate is prepared by cutting the paper cut into a triangular triangle having a bottom of 10 mm, a high 10 mm. The countertorious grooves are used to take a paper substrate using a 3.5 kV DC voltage applied to the shaver during the paper spray. If not specified, the ...

example 2

[0063] Example 2: Sample analysis using the probe of the present invention

[0064] Image 6 The serial picture A shows the system of the present invention. The system includes a probe that includes a porous material and a hollow member (eg, hollow capillary). The probe is coupled to the electrode via a porous material, and the probe produces an ion from the hollow member to, for example, a miniature mass spectrometer. The paper-capillary apparatus of the present invention can be fabricated in two different ways. The paper substrate can be used to crack from one side from one side to insert capillary ( Image 6 Continuous chassis B); or can be formed in the ET31 paper substrate, and can then push and embed the capillary and embedded in the slit ( Image 6 The connecting screen C). There is no significant performance difference between the devices made from the two modes. However, the latter manner may be more suitable for mass production of the device.

[0065] It is expected that ...

example 3

[0070] Example 3: Analysis of the probe of the present invention

[0071] Reference now image 3 It is shown in use figure 1 The apparatus and TSQ mass spectrometry (Thermo Scientific, San Jose, CA) in California were analyzed in 50 ng / ml cocaine in bovine blood. Whitman 31t paper with a thickness of 0.4 mm is used to make a trapezoidal shape. A 8 mm molten silica capsule (49 μM I. D. and 150 μM o.D.) was inserted into the substrate at about 3 mm deep. 5 μL of blood sample was loaded onto the paper substrate to form a dry blood spot. 30 μl of methanol was applied to the substrate to facilitate the analyte extract and spray ionization. 3000V is applied to initiate spray.

[0072] a) The extracted ion timing diagram recorded by the SRM transitions M / Z 304 to 182. b) MS / MS spectrum of precursor M / Z 304.

[0073] Reference now Figure 4 It is shown in use figure 1 The apparatus and mini 12 mass spectrometer for 10 ng / ml cocaine and 30 ng / ml Villapi in methanol solution were...

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PUM

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Abstract

The invention generally relates to probes, systems, cartridges, and methods of use thereof. In certain embodiments, the invention provides a probe including a porous material and a hollow member coupled to a distal portion of the porous material. The invention provides probes that interface well with mass spectrometers that employ a curtain gas and with miniature mass spectrometers. Aspects of the invention are accomplished by adding a hollow member (e.g., capillary emitter) to a porous substrate (e.g., paper substrate) for a paper-capillary spray. The data herein show that probes of the invention had significant, positive impact on the sensitivity and reproducibility for direct mass spectrometry analysis. The paper-capillary devices were fabricated and characterized for the effects due to the geometry, the treatment to the capillary emitters, as well as the sample disposition methods.

Description

[0001] Application [0002] This application claims the benefits and priorities of the US Temporary Application Serial No. 62 / 112, 799, filed on February 6, 2015, and the US Provisional Application Serial No. 62 / 211, 268, which are submitted on August 28, 2015, each of these temporary applications The content is incorporated herein by reference. [0003] governmental support [0004] The present invention is carried out under GM106016 granted by National Institutes ofhealth under government support. The government enjoys certain rights in the present invention. Technical field [0005] The present invention generally relates to probes, systems, boxes, and methods of use thereof. Background technique [0006] A paper sprayer has been developed for direct mass spectrometry of composite samples. The direct mass spectrometry has been implemented to sample analysis on mass spectrometers and micro mass spectrometers of commercial laboratory. Since its development, a set of unique adva...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): H01J49/04H01J49/26
CPCH01J49/0409H01J49/0445H01J49/26H01J49/167
Inventor 欧阳证任跃王骁
Owner PURDUE RES FOUND INC
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