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Application of chromosome instability score

An unstable, chromosomal technology, applied in the field of medical biological detection, to achieve the effect of prolonging survival, improving treatment efficiency, specificity and sensitivity

Pending Publication Date: 2022-01-25
上海缘悉生物科技有限公司
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  • Application Information

AI Technical Summary

Problems solved by technology

The current research has not yet seen cfDNA (circulating DNA) as an indicator for the prognosis of bone metastases, and there is no kit for evaluating the plasma cfDNA model of patients with bone metastases to judge the prognosis of patients with bone metastases before comprehensive treatment and provide Quantifiable indicators and objective basis for individualized treatment options

Method used

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  • Application of chromosome instability score
  • Application of chromosome instability score
  • Application of chromosome instability score

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Experimental program
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Embodiment

[0030] In order to find independent factors that can judge the prognosis of patients with bone metastases, cfDNA extraction and next-generation sequencing were performed on the peripheral blood of patients with bone metastases, and the map of cell-free DNA chromosomal heterogeneity in peripheral blood of patients with bone metastases was drawn, as shown in figure 1 As shown, the main variations are concentrated in 1q+, 3q+, 5p+, 6p+, 7+(EGFR), 8q+(MYC), 12+, 1p-, 3p-, 4-, 8p-, 13-, 17p-(TP53); By selecting some patients with bone metastases for verification, long-term (2 years) follow-up of their survival, and conducting correlation analysis with CIN and other factors, a series of calculation formulas and algorithms were developed, and finally it was determined that the CIN score evaluation index is related to the prognosis of bone metastases. independent risk factors. Subsequently, a prospective verification experiment was carried out on patients with bone metastases in clini...

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Abstract

The invention relates to application of chromosome instability score in preparation of an index reagent / kit for judging the lifetime of a patient suffering from panthenic carcinoma bone metastatic carcinoma. The peripheral blood cfDNA sequencing of a part of patients with the bone metastatic cancer discovers that the peripheral blood CIN score is remarkably related to the prognosis of the patients with the bone metastatic cancer. Prospective verification is carried out through a larger sample size: it is found in plasma collection and detection of clinical lung cancer patients, kidney cancer patients, liver cancer patients, breast cancer patients, prostate cancer patients, thyroid cancer patients and unknown primary bone metastatic cancer people that CIN score is significantly related to the survival time of the patients, the higher the CIN score is, the shorter the survival time of the patients is, and on the contrary, the lower the CIN score is, the longer the survival time of the patients is.

Description

technical field [0001] The invention relates to the technical field of medical biological detection, in particular to the application of chromosomal instability scoring. Background technique [0002] With the increasing incidence of tumors, human health and life are facing great challenges. In addition to the characteristics of rapid growth and aggressive growth, malignant tumors are characterized by metastasis and easy recurrence after treatment, which are the main reasons for treatment failure and eventual death. reason. Bone metastasis is one of the most common metastatic lesions, and it is the common outcome of many malignant tumors of tissues and organs. Therefore, it is particularly critical to choose a reasonable and effective treatment plan for patients with bone metastases. Bone metastases are considered to be a late stage of tumor development. However, due to differences in individual tumor gene characteristics and other aspects, the outcomes of different patient...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C12Q1/6886C12Q1/6869C12Q1/6806G16B20/00
CPCC12Q1/6886C12Q1/6869C12Q1/6806G16B20/00C12Q2600/112C12Q2600/118C12Q2535/122
Inventor 陈素钟南哲矫健杨明磊魏伟
Owner 上海缘悉生物科技有限公司
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