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Ionic liquid-reversed-phase micelle drug-loading delivery system for epidermal desensitization treatment, preparation method and application thereof

A technology of reversed-phase micelles and ionic liquids is applied in the field of biomedicine to achieve the effects of simple synthesis process, simple components and strong affinity

Active Publication Date: 2022-01-28
CHINA PHARM UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The purpose of the present invention is to overcome the deficiency of allergens crossing the skin barrier in the existing epidermal immunotherapy, and to provide an ionic liquid-reversed micellar drug delivery system for epidermal immunotherapy for allergic diseases and its preparation method and application

Method used

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  • Ionic liquid-reversed-phase micelle drug-loading delivery system for epidermal desensitization treatment, preparation method and application thereof
  • Ionic liquid-reversed-phase micelle drug-loading delivery system for epidermal desensitization treatment, preparation method and application thereof
  • Ionic liquid-reversed-phase micelle drug-loading delivery system for epidermal desensitization treatment, preparation method and application thereof

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preparation example Construction

[0059] 1. Preparation of OVA reversed-phase micelles

[0060] In this embodiment, the protein allergen is ovalbumin (OVA), the solvent of the protein allergen solution is water, the surfactant is sucrose fatty acid ester, the organic solvent is cyclohexane, and the oil phase is isopropyl myristate. As shown in Table 1.

[0061] The reverse phase micelles preparation method is:

[0062] (1) The protein allergen solution and the organic solvent solution containing the surfactant are prepared into a W / O emulsion and freeze-dried to obtain a freeze-dried product:

[0063] Precisely measure the prescription amount of sucrose fatty acid ester, put it into cyclohexane and dissolve it to prepare an organic phase, that is, an organic solvent solution containing a surfactant;

[0064] The prescription amount of water-soluble protein allergen ovalbumin (OVA) is added to the aqueous solvent to dissolve to prepare the water phase, that is, the protein allergen-containing solution.

[00...

Embodiment 22

[0098] Example 22: Synthesis of Ionic Liquid [Choline] [Oleic Acid]

[0099] The preparation method of ionic liquid is:

[0100] Adding the methanol solution of the organic carboxylic acid dropwise into the aqueous solution of the choline compound for reaction, the reaction solution is subjected to vacuum rotary evaporation and then vacuum-dried to remove the residual solvent to obtain the ionic liquid;

[0101] The present embodiment organic carboxylic acid is oleic acid. Weigh 13.21g of oleic acid, add 20mL of methanol to dissolve the oleic acid completely, the concentration of oleic acid in the methanol solution of oleic acid is 0.66g / mL, and the total volume of the methanol solution of oleic acid is 34.1mL.

[0102] The choline compound in this embodiment is choline hydroxide. Add 12mL of 0.44g / mL choline hydroxide aqueous solution at the bottom of the 50mL flask, add oleic acid methanol solution dropwise in the choline hydroxide solution, make the methanol solution (34....

Embodiment 23

[0103]Example 23: Synthesis of Ionic Liquid [Choline] [Lauric Acid]

[0104] The preparation method of ionic liquid is:

[0105] Adding the methanol solution of the organic carboxylic acid dropwise into the aqueous solution of the choline compound for reaction, the reaction solution is subjected to vacuum rotary evaporation and then vacuum-dried to remove the residual solvent to obtain the ionic liquid;

[0106] The present embodiment organic carboxylic acid is lauric acid. Weigh 8.73g lauric acid, add 20mL methanol to make lauric acid dissolve completely, the concentration of lauric acid in the methanol solution of lauric acid is 0.44g / mL, and the total volume of the methanol solution of lauric acid is 20.0mL.

[0107] The choline compound in this embodiment is choline hydroxide. Add 12mL 0.44g / mL choline hydroxide aqueous solution at the bottom of the 50mL flask, add dropwise lauric acid methanol solution in the choline hydroxide solution, make the methanol solution (20.0m...

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Abstract

The invention belongs to the technical field of biological medicines, and particularly relates to an ionic liquid-reversed-phase micelle drug-loading delivery system for epidermis desensitization treatment and preparation thereof. The ionic liquid-reverse micelle drug-loading delivery system is prepared from an ionic liquid prepared from a choline compound and an organic carboxylic acid and reverse micelles wrapping protein allergens. According to the prepared ionic liquid-reversed-phase micelle drug-loading delivery system, the cuticle structure is disturbed through the ionic liquid, lipid fluidization is promoted, and the transdermal efficiency of reversed-phase micelles is enhanced; the skin affinity of the protein allergen is improved through the reverse micelle, the protein stability is improved, and the release is controlled; and the ionic liquid-reversed-phase micelle drug-loading delivery system prepared by the invention is simple and convenient in synthesis process, high in transdermal efficiency, easy for local drug delivery of skin, good in safety and suitable for clinical desensitization treatment requirements.

Description

technical field [0001] The invention belongs to the technical field of biomedicine, and in particular relates to an ionic liquid-reversed micelles drug delivery system for epidermis desensitization treatment and its preparation method and application. Background technique [0002] Allergy is defined as a condition in which an adaptive immune response occurs in the body upon exposure to a surrounding antigen, and the immune response is altered during repeated exposure to the antigen due to memory of the antigen. Clinically, antihistamine drugs, allergic reaction mediator release drugs, histamine desensitization drugs, leukotriene receptor antagonists and other drugs are often used to treat the onset of anaphylaxis, but they cannot be cured. [0003] Immunotherapy is considered to be the only way to cure allergies by inducing defensive immunity using strategies that induce an adaptive immune response with the ability to induce antigen-specific long-term defensive memory, enabl...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/00A61K39/35A61K47/12A61K47/18A61K47/24A61P37/08A61K9/107A61K9/19
CPCA61K39/35A61K9/0014A61K47/12A61K47/186A61K47/24A61P37/08A61K9/1075A61K9/19
Inventor 丁杨周建平陈宗凯汪瑱
Owner CHINA PHARM UNIV
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