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Thiarabine- and thiarabine prodrug-based treatments

An alkyl, group technology, applied in the therapeutic field based on tiarabine and tiarabine prodrugs, can solve problems such as limitations

Pending Publication Date: 2022-01-28
SOUTHERN RES INST & IP
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the extension of these compounds to solid tumor applications (e.g., bladder, ovarian, and colorectal cancers) remains limited by their pharmacokinetic profiles

Method used

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  • Thiarabine- and thiarabine prodrug-based treatments
  • Thiarabine- and thiarabine prodrug-based treatments
  • Thiarabine- and thiarabine prodrug-based treatments

Examples

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example

[0558] The following examples are presented to provide one of ordinary skill in the art with a complete disclosure and description of how to make and evaluate the compounds, compositions, articles of manufacture, devices and / or methods claimed herein, and are intended purely as illustrations of the invention It is not intended to limit the scope of what the inventors believe to be their invention. Efforts have been made to ensure accuracy with respect to numbers (eg, amounts, temperature, etc.), but some errors and deviations should be accounted for. Unless indicated otherwise, parts are parts by weight, temperature is in °C or is at ambient temperature, and pressure is at or near atmospheric.

[0559] Examples are provided herein to illustrate the invention and should not be construed as limiting the invention in any way. Examples are provided herein to illustrate the invention and should not be construed as limiting the invention in any way.

[0560] 1. Chemical experiments ...

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Abstract

The present disclosure is concerned with combination therapies that include sulfur- based nucleotide and nucleoside compounds for the treatment of various cancers such as, for example, sarcomas, carcinomas, hematological cancers, solid tumors, breast cancer, cervical cancer, gastrointestinal cancer, colorectal cancer, brain cancer, skin cancer, prostate cancer, ovarian cancer, bladder cancer, thyroid cancer, testicular cancer, pancreatic cancer, endometrial cancer, melanomas, gliomas, leukemias, lymphomas, chronic myeloproliferative disorders, myelodysplastic syndromes, myeloproliferative neoplasms, and plasma cell neoplasms (myelomas). This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.

Description

[0001] Cross References to Related Applications [0002] This application claims the benefit of U.S. Provisional Application No. 62 / 857,686, filed June 5, 2019, the contents of which are hereby incorporated by reference in their entirety. Background technique [0003] Cancer is a disease primarily characterized by the uncontrolled division of abnormal cells derived from a given normal tissue and the invasion of adjacent tissues by these malignant cells. Blood or lymphatic transport can spread cancer cells to other parts of the body, leading to regional lymph nodes and distant sites (metastasis). Cancer is a complex multistep process that begins with tiny preneoplastic changes that may in some cases progress to neoplasia. There are more than 100 different types of cancer that can be grouped into broader categories. Major categories include carcinomas, sarcomas, leukemias, lymphomas, and myelomas, as well as cancers of the central nervous system. Cancer rates continue to cli...

Claims

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Application Information

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IPC IPC(8): A61K31/5415
CPCA61K31/7068A61K31/708A61K31/7076C07K16/2818C07K2317/76C07K2317/24A61K39/3955A61P35/00A61K2300/00
Inventor O·穆哈-查菲克M·J·苏乔J·刘R·博海科
Owner SOUTHERN RES INST & IP