Chromene-based compounds, methods and uses thereof

A technology of compounds and hydrates, applied in organic chemistry, pharmaceutical formulations, drug combinations, etc., can solve problems such as impermissible molecules

Pending Publication Date: 2022-02-08
UNIVERSITY OF MINHO
View PDF0 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the described system does not allow the generation of molecules in which the aromatic units incorporate different substituents

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Chromene-based compounds, methods and uses thereof
  • Chromene-based compounds, methods and uses thereof
  • Chromene-based compounds, methods and uses thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0097] The present invention relates to a new class of benzopyranyl anticancer compounds. The present invention describes the anticancer properties of a new class of benzopyranyl anticancer compounds. The present invention also describes methods for the synthesis and isolation of new classes of benzopyranyl anticancer compounds.

[0098] In particular, the present invention describes methods for the synthesis of novel benzopyranyl compounds by combining at least two different molecules, thus generating compounds with relevant biological profiles of interest.

[0099] In one embodiment, 19 different benzopyran-imidazolyl compounds were isolated. Table 1 shows the benzopyranyl skeleton structure and 19 synthesized and isolated benzopyran-imidazolyl compounds.

[0100] Table 1: Structures of Benzopyranyl Compounds

[0101]

[0102]

[0103]

[0104] In one embodiment, the cell growth inhibition and IC of the synthesized and isolated benzopyranyl compounds are determin...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

No PUM Login to view more

Abstract

The present disclosure relates to a compound or a pharmaceutically acceptable salt, hydrate, solvate, N -oxide, stereoisomer, diastereoisomer, enantiomer, atropisomer, dimer, or polymorph for use in medicine comprising the following formula (I) shown in the specification, wherein R1, R2 and R3 are independently selected from each other; R1 is selected from an aryl, or heterocyclic ring; R2 is selected from H, alkyl, aryl, alcoxyl, halogen, hydroxyl, amine, carbonyl, or a heterocyclic ring; R3 is selected from H, or (II).

Description

technical field [0001] The present invention relates to a new class of benzopyranyl anticancer compounds. The present invention describes the anticancer properties of a new class of benzopyranyl anticancer compounds. The present invention also describes methods for the synthesis and isolation of new classes of benzopyranyl anticancer compounds. Background technique [0002] In 2018, cancer killed nearly 10 million people worldwide, and 18.1 million new cancer cases were detected in the same year. 1 The incidence of the disease is expected to exceed 43 million in 5 years. This demonstrates the urgency of discovering new and better treatments. Due to the overall increase in the number of cases and associated mortality, this problem must be addressed globally. In 2018, breast cancer accounted for 6.6% of cancer deaths. Breast cancer is the fifth deadliest cancer type; in 2018, 11.6% of new cases (>2 million cases) were detected. 2 It is the second most common type of c...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
IPC IPC(8): C07D491/052C07D519/00A61K31/4188A61P35/00A61P35/02
CPCC07D491/052C07D519/00A61P35/00A61P35/02
Inventor 玛尔塔·西尔维娅·弗雷塔斯·达·科斯塔马里亚·德·法蒂玛·蒙吉尼奥·巴尔塔萨玛丽亚·费尔南达·德·热苏斯·雷戈·派瓦·普罗恩萨帕特里夏·马西埃尔奥利维娅·亚历山德拉·埃利亚斯·庞特斯
Owner UNIVERSITY OF MINHO
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap