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Chromene-based compounds, methods and uses thereof

A technology of compounds and hydrates, applied in organic chemistry, pharmaceutical formulations, drug combinations, etc., can solve problems such as impermissible molecules

Pending Publication Date: 2022-02-08
UNIVERSITY OF MINHO
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, the described system does not allow the generation of molecules in which the aromatic units incorporate different substituents

Method used

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  • Chromene-based compounds, methods and uses thereof
  • Chromene-based compounds, methods and uses thereof
  • Chromene-based compounds, methods and uses thereof

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Embodiment Construction

[0097] The present invention relates to a new class of benzopyranyl anticancer compounds. The present invention describes the anticancer properties of a new class of benzopyranyl anticancer compounds. The present invention also describes methods for the synthesis and isolation of new classes of benzopyranyl anticancer compounds.

[0098] In particular, the present invention describes methods for the synthesis of novel benzopyranyl compounds by combining at least two different molecules, thus generating compounds with relevant biological profiles of interest.

[0099] In one embodiment, 19 different benzopyran-imidazolyl compounds were isolated. Table 1 shows the benzopyranyl skeleton structure and 19 synthesized and isolated benzopyran-imidazolyl compounds.

[0100] Table 1: Structures of Benzopyranyl Compounds

[0101]

[0102]

[0103]

[0104] In one embodiment, the cell growth inhibition and IC of the synthesized and isolated benzopyranyl compounds are determin...

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Abstract

The present disclosure relates to a compound or a pharmaceutically acceptable salt, hydrate, solvate, N -oxide, stereoisomer, diastereoisomer, enantiomer, atropisomer, dimer, or polymorph for use in medicine comprising the following formula (I) shown in the specification, wherein R1, R2 and R3 are independently selected from each other; R1 is selected from an aryl, or heterocyclic ring; R2 is selected from H, alkyl, aryl, alcoxyl, halogen, hydroxyl, amine, carbonyl, or a heterocyclic ring; R3 is selected from H, or (II).

Description

technical field [0001] The present invention relates to a new class of benzopyranyl anticancer compounds. The present invention describes the anticancer properties of a new class of benzopyranyl anticancer compounds. The present invention also describes methods for the synthesis and isolation of new classes of benzopyranyl anticancer compounds. Background technique [0002] In 2018, cancer killed nearly 10 million people worldwide, and 18.1 million new cancer cases were detected in the same year. 1 The incidence of the disease is expected to exceed 43 million in 5 years. This demonstrates the urgency of discovering new and better treatments. Due to the overall increase in the number of cases and associated mortality, this problem must be addressed globally. In 2018, breast cancer accounted for 6.6% of cancer deaths. Breast cancer is the fifth deadliest cancer type; in 2018, 11.6% of new cases (>2 million cases) were detected. 2 It is the second most common type of c...

Claims

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Application Information

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IPC IPC(8): C07D491/052C07D519/00A61K31/4188A61P35/00A61P35/02
CPCC07D491/052C07D519/00A61P35/00A61P35/02
Inventor 玛尔塔·西尔维娅·弗雷塔斯·达·科斯塔马里亚·德·法蒂玛·蒙吉尼奥·巴尔塔萨玛丽亚·费尔南达·德·热苏斯·雷戈·派瓦·普罗恩萨帕特里夏·马西埃尔奥利维娅·亚历山德拉·埃利亚斯·庞特斯
Owner UNIVERSITY OF MINHO
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