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Medical use of NEDDylation blocker

A use, drug technology, applied in the application field in the field of anti-tumor

Inactive Publication Date: 2022-02-18
LONGHUA HOSPITAL SHANGHAI UNIV OF TRADITIONAL CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, in addition to the NAE inhibitors of sulfonamide esters, there are few NEDDylation ubiquitin-like modification inhibitors reported at this stage, so it is still very urgent to discover and develop new Neddylation modification pathway blockers for the treatment of tumors

Method used

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  • Medical use of NEDDylation blocker
  • Medical use of NEDDylation blocker
  • Medical use of NEDDylation blocker

Examples

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Embodiment Construction

[0023] The present invention will be further described below in conjunction with the accompanying drawings and specific implementation. These examples should be understood as only for illustrating the present invention but not for limiting the protection scope of the present invention. After reading the contents of the present invention, those skilled in the art can make various changes or modifications to the present invention, and these equivalent changes and modifications also fall within the scope defined by the claims of the present invention.

[0024] In the following examples of the present invention, the compound represented by formula I is the traditional Chinese medicine monomer camptothecin (Camptothecin, CPT) extracted from camptotheca japonica according to the commonly used extraction method in the field of traditional Chinese medicine, or a commercially available product.

[0025] In the following examples of the present invention, cells and reagents that are not...

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Abstract

The invention relates to application of a compound shown in a formula I in preparation of a medicine for preventing, delaying or treating NEDDylation modification pathway participated or mediated diseases, in particular to application in the anti-tumor field. A biological activity test result shows that the compound shown in the formula I has an effect of blocking an NEDDylation modification pathway and also has a remarkable proliferation inhibition effect. Therefore, the compound shown in the formula I can be used for developing antitumor drugs.

Description

technical field [0001] The present invention relates to the medical use of NEDDylation modification pathway blockers, and specifically provides the medical use of the compound represented by formula I in preventing, delaying or treating diseases in which NEDDylation modification pathway is involved or mediated, especially the application in the field of anti-tumor . Background technique [0002] Due to its high morbidity and mortality, tumors have surpassed cardiovascular diseases and become a worldwide problem that affects human health and restricts the development of human society. According to the forecast of the World Health Organization (WHO), by 2020, there will be 20 million new cancer cases worldwide and 12 million deaths. However, due to the low rate of early diagnosis, inability to cure in the middle and late stages, recurrence and metastasis, the treatment of tumors has not been able to make substantial progress. In recent years, various antineoplastic drugs inc...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/4745A61P35/00A61P35/02
CPCA61K31/4745A61P35/00A61P35/02
Inventor 贾立军衡永青梁余培张军千
Owner LONGHUA HOSPITAL SHANGHAI UNIV OF TRADITIONAL CHINESE MEDICINE
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