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Novel material for skin wound closure and scar prevention

A skin, wound technology, applied in the field of organic chemistry and pathology, medicine, can solve problems that limit the potential of clinical application

Pending Publication Date: 2022-02-18
UNIVERSITY OF CHICAGO
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

4-8 While these approaches could potentially be used to deliver TGF-β inhibitors at optimal time points to reduce scarring, they have not been validated for this purpose
Furthermore, they require complex 3D microfabrication equipment, which limits their potential for clinical application

Method used

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  • Novel material for skin wound closure and scar prevention
  • Novel material for skin wound closure and scar prevention
  • Novel material for skin wound closure and scar prevention

Examples

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Effect test

Embodiment 1

[0057] Example 1 - In Situ Generated Timed Pulse Release Dressing for Reducing Excessive Scar Growth

[0058] Scarring usually occurs after deep trauma, severe burns, or surgical incisions. It can have a profound impact on a patient's quality of life and presents a huge challenge to physicians. One way to overcome scarring is to inhibit collagen synthesis by blocking transforming growth factor-beta (TGF-beta). However, the timing of TGF-β inhibition is critical, as blocking signaling prematurely will lead to poor wound healing, while blocking after peak collagen synthesis will limit the effect of scar reduction. Therefore, the inventors developed a novel composite wound photogel dressing for the timed release of at least one TGF-β inhibitor in vivo. Specifically, the inventors designed a timing buffer containing poly(lactic acid-co-glycolic acid)-o-nitrobenzene derivatives (PLGA-NB) by using the water-in-oil-in-water (W / O / W) emulsion evaporation method. release drug deliver...

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Abstract

Methods and compositions for preventing or inhibiting the formation of scars are disclosed. The methods and compositions include a TGF-beta inhibitor provided in a delayed release composition.

Description

[0001] Related Application Cross Reference [0002] This application claims priority to U.S. Provisional Patent Application No. 62 / 845,648, filed May 9, 2019, which is incorporated herein by reference in its entirety. [0003] Statement of Government Support [0004] This invention was made with government support under grant number R01OD023700 awarded by the National Institutes of Health. The government has certain rights in inventions. [0005] Background of the invention 1. Technical field [0006] The present invention relates to the fields of medicine, organic chemistry and pathology. 2. Background technology [0007] Scarring usually occurs after deep trauma, severe burns, or surgical incisions. It can have a profound impact on a patient's quality of life and presents a huge challenge to physicians. One way to overcome scarring is to inhibit collagen synthesis by blocking transforming growth factor-beta (TGF-beta). However, the timing of TGF-β inhibition is ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K38/17A61F2/00A61L27/36
CPCA61K31/4439A61L26/0023A61L26/0066A61L2300/436A61L2300/622A61K9/0019A61K9/4866C08L5/08A61P17/02A61K9/0014A61K9/5031A61K41/00A61K47/10A61K47/32A61K47/34A61K47/36A61L27/26A61L27/54A61L27/60A61L2300/414
Inventor 吴小阳张健
Owner UNIVERSITY OF CHICAGO
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