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Compositions and methods for treating biofilm-related lung conditions

A composition, biofilm technology, applied to biofilm-associated infection in the respiratory tract, composition of biofilm-associated infection, biofilm infection, treatment, destruction and/or prevention of biofilm composition field, able to solve intractable Restoring physiological functions, disrupting innate immune homeostasis, etc.

Pending Publication Date: 2022-02-22
LOCUS IP CO LLC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Unfortunately, however, these treatments fail to restore normal physiology and disrupt innate immune homeostasis

Method used

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Examples

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Embodiment Construction

[0031] The present invention provides compositions and methods for treating, disrupting and / or preventing biofilm formation. This includes treating, disrupting and / or preventing the formation of biofilms in the respiratory system of the subject, and treating and / or preventing the development of symptoms, comorbidities and diseases associated with biofilm-associated infections in the subject. In particular, the present invention provides compositions and methods for treating and / or preventing biofilm-associated infections in the lung. Advantageously, the present invention enhances methods currently used to combat antibiotic resistant strains of pathogenic bacteria.

[0032] Definition of choice

[0033] As used herein, the term "subject" refers to an animal, such as a mammal, that has been infected or is at risk of being infected by a biofilm-forming pathogen. Animals can be, for example, pigs, horses, goats, cats, mice, rats, dogs, primates (such as apes, chimpanzees, and or...

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PUM

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Abstract

The subject invention provides materials and methods for preventing, inhibiting or reducing biofilm formation and biofilm infections, in particular, in the respiratory tract of a subject. The invention utilizes growth by-products of beneficial microorganisms to enhance the effectiveness of biocidal substances in the treatment, disruption and / or prevention of biofilms. Advantageously, the subject invention is useful against antibiotic-resistant bacterial strains, such as MRSA, Helicobacter pylori, S. pneumoniae, P. aeruginosa and A. fumigatus.

Description

[0001] Cross References to Related Applications [0002] This application claims priority to U.S. Provisional Patent Application No. 62 / 846,084, filed May 10, 2019, which is incorporated herein by reference in its entirety. Background technique [0003] Antibiotics are a major tool in the treatment of infections, often based on the efficiency of microbial kill studied in the free-floating (planktonic) state, acting as individual cells. For example, quantification of antibiotic efficacy is accomplished in traditional minimum inhibitory concentration (MIC) assays. However, certain microbial growth, including many human (and other animal) infections, is now thought to be caused or exacerbated by entire microbial colonies, often consisting of microbes working together in a biofilm state. Biofilms comprise adherent extracellular components that surround and protect the colony from environmental aggressions such as antibiotics and the immune system. [0004] Biofilms have broad cl...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K45/06A61K47/26A61K47/42A61K47/14A61P11/00A61P31/04A61P31/10
CPCA61K45/06A61K47/26A61K47/42A61K47/14A61P11/00A61P31/04A61P31/10A61K31/7012A61K38/12A61K31/23A61K31/704A61K31/43A61K31/65A61K31/545A61P31/00A61K2300/00
Inventor 肖恩·法默肯·阿里贝克
Owner LOCUS IP CO LLC