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Red ginseng homogeneous polysaccharide and application thereof in preparation of myocardial ischemia injury protection medicine

A myocardial ischemia, uniform technology, applied in the direction of drug combination, cardiovascular system diseases, pharmaceutical formulations, etc., can solve the problems of less research on the structure and function of red ginseng polysaccharides, and achieve good free radical scavenging activity and good antioxidant activity Effect

Active Publication Date: 2022-04-05
CHINA PHARM UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The main medicinal components of red ginseng are saponins and polysaccharides, among which the research reports on red ginseng saponins are more abundant, while the researches on the structure and function of red ginseng polysaccharides are less

Method used

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  • Red ginseng homogeneous polysaccharide and application thereof in preparation of myocardial ischemia injury protection medicine
  • Red ginseng homogeneous polysaccharide and application thereof in preparation of myocardial ischemia injury protection medicine
  • Red ginseng homogeneous polysaccharide and application thereof in preparation of myocardial ischemia injury protection medicine

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0034]The method for extracting and separating and purifying red ginseng polysaccharides from red ginseng comprises the following steps:

[0035] Step (1), raw material pretreatment: according to the mass volume ratio of red ginseng decoction pieces and petroleum ether (60-90°C) is 1:4 (m / v, g:mL), add petroleum ether to red ginseng decoction pieces, let stand 12h for degreasing treatment to remove petroleum ether, dry the red ginseng decoction pieces, and smash into red ginseng particles with a size of 0.1-0.2cm;

[0036] Step (2), reflux extraction: Put the red ginseng granules into the reflux extraction equipment, add pure water according to the ratio of material to liquid (m / v, g:mL) 1:15, first soak for 2 hours, then heat and reflux extraction, set the reflux The temperature of extraction is 95°C, each extraction is 2h, extraction is 2 times, each extraction is completed and filtered, and the filtrates are combined to obtain the extract;

[0037] Step (3), alcohol precip...

Embodiment 3

[0079] Embodiment 3 in vivo pharmacodynamics experiment

[0080] Animal grouping and administration: the mice were divided into 6 groups according to the random number table method: blank group, model group, positive group (propranolol, 40mg / kg), red ginseng homogeneous polysaccharide RGP2-1 high-dose group (RGP- H, 400mg / kg), red ginseng homogeneous polysaccharide RGP2-1 medium dose group (RGP-M, 200mg / kg), red ginseng homogeneous polysaccharide RGP2-1 low dose group (RGP-L, 100mg / kg) dose group, each Group 10. Intragastric administration, the blank group and the model group were intragastrically administered equal volumes of distilled water, once a day, for 10 consecutive days, free to drink water and food during the administration period, and recorded body weight changes and death conditions during the administration period.

[0081] Establishment of the animal model: except the blank group, the other groups were intraperitoneally injected with ISO (isoproterenol, 60 mg / kg...

Embodiment 4

[0120] Take red ginseng homogeneous polysaccharide RGP2-15000mg, add appropriate amount of gelatinized starch, microcrystalline cellulose and hydroxypropyl cellulose, press the conventional process of pharmaceutical tablet, make 500 tablets, each containing 10mg red ginseng The homogeneous polysaccharide RGP2-1 is used as anti-myocardial ischemia preparation or health product. Usage and Dosage: Take orally, 1 tablet each time, 2 times a day, reduce as appropriate for children, 15 days as a course of treatment.

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Abstract

The invention discloses a red ginseng homogeneous polysaccharide which is mainly composed of Rha, GalA, Glc and Gal, the molar ratio of Rha to GalA to Glc to Gal is (1-10): (1-10): (1-12): (0.5-3), and the weight-average molecular weight is 25 kDa to 45 kDa. The red ginseng homogeneous polysaccharide takes-> 1)-alpha-D-Rhap-(2->,-> 1)-alpha-D-GalpA-(4->) as a main chain, and takes-> 1)-alpha-D-Glcp-(4->, T-beta-D-Glcp and T-alpha-D-Galp as side chains. The red ginseng homogeneous polysaccharide has good free radical scavenging activity and antioxidant activity, and can play a role in protecting myocardial ischemia injury by reducing myocardial enzyme, increasing various indexes such as SOD (superoxide dismutase) and the like as well as oxidative stress injury of myocardial tissues. The invention further discloses application of the red ginseng homogeneous polysaccharide in preparation of myocardial ischemia resisting drugs or application of the red ginseng homogeneous polysaccharide in preparation of antioxidant drugs.

Description

technical field [0001] The present invention relates to a natural ingredient and its application, to a red ginseng homogeneous polysaccharide component and its application in the preparation of myocardial ischemia injury protection drugs, in particular to a red ginseng homogeneous polysaccharide and its use in the preparation of oxidative stress myocardial ischemia Application in blood injury protection drugs. Background technique [0002] With the improvement of living standards, cardiovascular disease is becoming younger and currently ranks first in the death of residents in my country. Myocardial ischemia injury is the abnormal myocardial energy metabolism caused by the reduction of cardiac blood supply and insufficient oxygen supply, which leads to pathological changes in myocardial structure and function. A large number of clinical and research studies have shown that oxidative stress and inflammatory response play an important role in myocardial ischemia-reperfusion i...

Claims

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Application Information

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IPC IPC(8): C08B37/00A61K31/732A61K36/258A61P9/10A61P39/06A61K125/00
Inventor 贾晓斌廉源沛封亮王贤峰
Owner CHINA PHARM UNIV
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