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Micro-needle patch for resisting wrinkles and preserving moisture as well as preparation method and application of micro-needle patch

A technology of micro-needle stickers and active ingredients, which can be used in cosmetic preparations, skin care preparations, pharmaceutical formulations, etc., can solve the problems of poor anti-wrinkle moisturizing effect and other problems, and achieve anti-wrinkle moisturizing effect and good effect.

Pending Publication Date: 2022-04-12
中科广州再生医学科技开发有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] Currently on the market, recombinant collagen is used in the field of beauty cosmetics mainly for facial masks, essences, repairing lotions, moisturizing lotions, toners, etc. Acupuncture is not effective in anti-wrinkle moisturizing, so there is room for improvement

Method used

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  • Micro-needle patch for resisting wrinkles and preserving moisture as well as preparation method and application of micro-needle patch
  • Micro-needle patch for resisting wrinkles and preserving moisture as well as preparation method and application of micro-needle patch
  • Micro-needle patch for resisting wrinkles and preserving moisture as well as preparation method and application of micro-needle patch

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0037] A microneedle patch for anti-wrinkle and moisturizing, comprising a base and needle tips loaded with active ingredients, the active ingredients include the following components by weight:

[0038] Sodium Hyaluronate 5.0g, Recombinant Collagen 1.0g, Hydroxypropyltetrahydropyrantriol 1.0g, Tetrahydromethylpyrimidinecarboxylic Acid 0.5g, Acetyl Hexapeptide-8 0.2g and Palmitoyl Pentapeptide-4 0.2g.

[0039] The preparation method of the above-mentioned microneedle patch for anti-wrinkle and moisturizing comprises the following steps:

[0040] 1) Weigh the above components according to the proportion, dissolve the components with purified water, mix them uniformly with a homogeneous mixer to prepare a 100ml solution, and perform centrifugal defoaming on the solution at a centrifugal speed of 1500rpm and a centrifugal time of 10min , detect the pH value of the solution;

[0041] 2) Transfer the solution configured in step 1) to a polydimethylsiloxane (PDMS) microneedle mold...

Embodiment 2

[0043] A microneedle patch for anti-wrinkle and moisturizing, comprising a base and needle tips loaded with active ingredients, the active ingredients include the following components by weight:

[0044] Sodium Hyaluronate 2.5g, Recombinant Collagen 0.5g, Hydroxypropyltetrahydropyrantriol 0.5g, Tetrahydromethylpyrimidinecarboxylic Acid 0.8g, Acetyl Hexapeptide-8 0.1g and Palmitoyl Pentapeptide-4 0.1g.

[0045] The preparation method of the above-mentioned microneedle patch for anti-wrinkle and moisturizing comprises the following steps:

[0046] 1) Weigh the above components according to the proportion, dissolve the components with purified water, mix them uniformly with a homogeneous mixer to prepare a 100ml solution, and perform centrifugal defoaming on the solution at a centrifugal speed of 1500rpm and a centrifugal time of 10min , detect the pH value of the solution;

[0047] 2) Transfer the solution configured in step 1) to a polydimethylsiloxane (PDMS) microneedle mold, ...

Embodiment 3

[0049] A microneedle patch for anti-wrinkle and moisturizing, comprising a base and needle tips loaded with active ingredients, the active ingredients include the following components by weight:

[0050] Sodium Hyaluronate 7.5g, Recombinant Collagen 1.5g, Hydroxypropyltetrahydropyrantriol 1.5g, Tetrahydromethylpyrimidinecarboxylic Acid 0.2g, Acetyl Hexapeptide-8 0.3g and Palmitoyl Pentapeptide-4 0.3g.

[0051] The preparation method of the above-mentioned microneedle patch for anti-wrinkle and moisturizing comprises the following steps:

[0052] 1) Weigh the above components according to the proportion, dissolve the components with purified water, mix them uniformly with a homogeneous mixer to prepare a 100ml solution, and perform centrifugal defoaming on the solution at a centrifugal speed of 1500rpm and a centrifugal time of 10min , detect the pH value of the solution;

[0053] 2) Transfer the solution configured in step 1) to a polydimethylsiloxane (PDMS) microneedle mold...

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Abstract

The invention relates to the technical field of cosmetic beauty, and particularly discloses a microneedle patch for resisting wrinkles and preserving moisture as well as a preparation method and application of the microneedle patch. The microneedle patch for resisting wrinkles and preserving moisture comprises a substrate and a needle tip loaded with active ingredients, and the active ingredients comprise the following components in parts by weight: 2.5 to 7.5 parts of sodium hyaluronate, 0.5 to 1.5 parts of recombinant collagen, 0.5 to 1.5 parts of hydroxypropyl tetrahydropyrantriol, 0.2 to 0.8 part of tetrahydromethylpyrimidine carboxylic acid, 0.1 to 0.3 part of acetyl hexapeptide-8 and 0.1 to 0.3 part of palmitoyl pentapeptide-4. The microneedle patch is composed of the needle tip capable of puncturing the cuticle of the skin and the substrate, the needle tip is loaded with the specific active ingredients, and when the needle tip punctures the cuticle and sends the active ingredients to the subcutaneous part, wrinkles can be effectively removed, and the anti-wrinkle and moisturizing effects are achieved.

Description

technical field [0001] The invention relates to the technical field of cosmetics and cosmetics, in particular to a microneedle patch for anti-wrinkle and moisturizing and its preparation method and application. Background technique [0002] As a method for effective drug delivery of various medicines applied to the human body, a method of injecting medicines in a liquid form through a hypodermic needle is widely used. However, a hypodermic needle with a diameter of about several millimeters irritates many pain points existing in the skin, thereby causing pain to the patient. Compared with traditional hypodermic needle drug delivery, microneedles (MNs) are small in size, and the length of the needle is usually less than 1 mm. Due to their micron-scale size, MNs can seamlessly pierce the stratum corneum of the skin and form microscopic lesions on the skin surface. channel, and the active macromolecules (including therapeutic molecules with a wide range of molecular weights, s...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K8/02A61K8/49A61K8/64A61K8/65A61K8/73A61Q19/00A61Q19/08
Inventor 龙小玲龙斌
Owner 中科广州再生医学科技开发有限公司
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