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Polyethylene and collagen coating-based rotator cuff patch and preparation method thereof

A technology of polyethylene and collagen, which is applied in the field of rotator cuff patch and patch preparation, can solve the problems of local inflammation and foreign body reaction, and achieve the effect of slowing down foreign body reaction

Pending Publication Date: 2022-04-29
福州市第二医院
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Artificial grafts have advantages in terms of biomechanics, but there are problems such as foreign body reactions or local inflammation

Method used

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  • Polyethylene and collagen coating-based rotator cuff patch and preparation method thereof
  • Polyethylene and collagen coating-based rotator cuff patch and preparation method thereof
  • Polyethylene and collagen coating-based rotator cuff patch and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0040] Example 1 Preparation of patch

[0041] First, prepare 0.1-0.5mol / l acetic acid aqueous solution.

[0042] Collagen mother liquor and 0.1-0.5mol / l acetic acid aqueous solution are dissolved in a weight ratio of 1:20-30. The specific steps are as follows: first, put the accurately weighed collagen mother liquor into the beaker, add about 4-15 times the volume of acetic acid aqueous solution, and magnetic stirring for about 0.5-2h to ensure that the temperature is lower than 20-25 ℃ until the solution in the beaker is homogeneous; Then add the remaining acetic acid aqueous solution and stir until it is completely dissolved. At this time, the solution is viscous; The viscous solution is sub packed into a 6-well cell culture plate. After freezing at - 50-100 ℃ for 0.5-3h, it is quickly placed in a freeze dryer for vacuum freeze drying for 1-3 days. The obtained collagen sponge is purified acid soluble type I collagen and stored in a vacuum dryer for use.

[0043] Weigh an appro...

Embodiment 2

[0048] Example 2 performance test

[0049] Animal experiment group: a. uphwe group; b. Uphwe collagen coating group;.

[0050] The ends of the humeral bone and the sleeve are knitted to fix the bone. The size of the woven patch is 10mm long, 4mm wide and 2mm thick. It is suitable for the suture model of rabbit infraspinatus tendon. The biomechanical test of the sutured patch meets the maximum demand of about 130n for rabbit infraspinatus muscle tear.

[0051] ① 2.5-3.5kg New Zealand white rabbits, after anesthesia, prepare the skin of the shoulder joint, make about 4cm parallel incision above the infraspinatus tendon, blunt separation layer by layer, and expose the infraspinatus tendon. The infraspinatus muscle was excised close to the humeral stop and a defect of about 6mm was made.

[0052] ② The patch and the infraspinatus muscle stump were sutured with 4mm overlap. Two 1mm bone channels were made at the end of the humeral head, penetrated into the patch suture at the other end...

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Abstract

A rotator cuff patch based on polyethylene and a collagen coating comprises a rotator cuff patch body, a UPHWE patch substrate layer, an anti-inflammatory drug loading layer containing one or more collagens of aspirin and celecoxib, and a healing promoting drug loading layer containing one or more collagens of VEGF and TGF beta, and the rotator cuff patch realizes early inhibition of inflammatory response, and has the advantages of high bioavailability, high bioavailability, high bioavailability and high safety. In the repair period, blood vessel formation is promoted to achieve the effect of promoting graft integration.

Description

technical field [0001] The invention belongs to the field of tissue repair, in particular to a rotator cuff patch based on polyethylene and collagen, which is used for the repair of rotator cuff, inhibits the occurrence and development of inflammation, is conducive to further play the role of promoting healing, and a method for preparing patch. Background technology [0002] Rotator cuff tear can cause joint pain, weakened function, stiffness and limited range of motion, and make the society bear a huge economic burden. Huge rotator cuff tear refers to the rotator cuff injury with tear opening > 5cm or involving ≥ 2 tendons. At present, the treatment is mainly surgical repair. The shoulder function of some patients has been greatly improved, but the re tear rate is high, up to 15% ~ 94%. The cause of re tear is related to tear size, blood supply, fat infiltration, age, smoking and muscle atrophy. Some studies have shown that there is a great correlation between tear size and r...

Claims

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Application Information

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IPC IPC(8): A61L27/40A61L27/16A61L27/34A61L27/28A61L27/54A61L27/50
CPCA61L27/16A61L27/34A61L27/28A61L27/54A61L27/50A61L2430/10A61L2300/414A61L2300/41A61L2300/602A61L2400/12A61L2400/04A61L2300/21A61L2300/204A61L2420/04A61L2420/06A61L2420/08A61L2420/02C08L89/00C08L23/06
Inventor 张韬刘楠楠吴冬枝何文慧
Owner 福州市第二医院
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