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Targeted nano-composite as well as preparation method and application thereof

A nano-composite and complex technology, applied in the field of medicine, can solve the problem that chemotherapy is difficult to produce good effects, and achieve the effects of improving metabolic kinetics and physicochemical properties, improving selectivity, and reducing toxic and side effects

Pending Publication Date: 2022-05-03
CIXI INST OF BIOMEDICAL ENG NINGBO INST OF MATERIALS TECH & ENG CHINESE ACAD OF SCI +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] According to one aspect of the present application, a targeted nanocomplex is provided, which can realize the combined treatment of radioisotope therapy and other functional treatments, and solve the problem that a single chemotherapy is difficult to produce good results

Method used

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  • Targeted nano-composite as well as preparation method and application thereof
  • Targeted nano-composite as well as preparation method and application thereof
  • Targeted nano-composite as well as preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment approach

[0087] In one embodiment of the present application, the preparation method of the targeting nanocomposite can be:

[0088] Step 1, reacting the bio-targeting molecule with raw material I of the activated nanocarrier, dialysis in water for 72 hours after reacting for 12 hours, and then freeze-drying to obtain a mixture containing the bio-targeting molecule;

[0089] Step 2, according to the mass ratio of radioisotope and raw material I is 1:20-30, add a solution containing radioisotope, the reaction conditions are: use an oscillator to vibrate the mixture at 26°C for 30 minutes and then purify the reactant

[0090] Step 3, then according to the mass ratio of the synergistic therapeutic functional substance to the raw material I is 1:20-30, add the above mixture containing the biological targeting molecule into the solution or dispersion of the synergistic therapeutic functional substance, and bathe in 60°C for 20 minutes to obtain The targeting nanocomplex.

[0091] In anothe...

Embodiment 1

[0095] Example 1 Nanocomposite D1 NPY(28-36)- 211 At-doxorubicin-liposome preparation method:

[0096]NPY(28-36) was incorporated into the nanocomplex through the amide bond in the chemical bond. The macromolecule substance pegylated liposome with carboxyl functional group utilizes 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride (EDC), N-hydroxysuccinimide After (NHS) activation for 22 hours, add NPY (28-36) exposed to the amino end, and the ratio of NPY (28-36) to PEGylated liposomes is 1:20, so that the amino groups of NPY (28-36) The carboxyl group of the pegylated liposome forms an amide bond to connect with each other, reacts at 4°C for 12 hours, dialyzes in water for 72 hours, and freeze-dries to obtain a complex coupled with biological targeting molecules.

[0097] Will 211 At and doxorubicin were loaded into the complex coupled with NPY. According to the mass ratio of doxorubicin to the complex coupled with the bio-targeting molecule obtained above is 2...

Embodiment 2

[0098] The preparation of embodiment 2 nanocomposites D2~D203

[0099] In this example, nanocomposites D2-D203 were prepared, and the specific operations were the same as in Example 1; see Table 1 for other conditions.

[0100] Table 1

[0101]

[0102]

[0103]

[0104]

[0105]

[0106]

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Abstract

The invention discloses a targeted nano-composite and a preparation method and application thereof, and the targeted nano-composite comprises a nano-carrier, biological targeted molecules, radioisotopes and a synergistic treatment functional substance; the biological targeting molecule is in coupling connection with the nano-carrier; the synergistic treatment functional substance is loaded in the nano-carrier; the radioactive isotope is carried on the nano-carrier. The targeted nano compound provided by the invention has a tumor targeted treatment effect, and by modifying an existing anti-cancer nano preparation, the selectivity of a drug to tumor tissues is improved, directional delivery and gradual release of the drug are realized, the metabolic kinetics and physicochemical properties of the drug are improved, and the toxic and side effects of the drug are reduced. Meanwhile, combined treatment of radioisotope treatment and chemotherapy or photothermal treatment or photodynamic treatment or sonodynamic treatment or magnetic thermal treatment can be achieved, and the problem that a good effect is difficult to generate through single chemotherapy is solved.

Description

technical field [0001] The application relates to a targeted nanocomposite and its preparation method and application, belonging to the field of medicine. Background technique [0002] Cancer is still a serious problem facing human health. There are approximately 14 million new cancer patients and 8 million deaths from cancer-related diseases worldwide each year. That's why researchers around the world have been working to develop more precise and faster treatments to fight cancer. Due to the superiority of nanomaterials, it has been extensively studied in the diagnosis and treatment of tumors. In particular, nanomaterials can integrate a variety of therapeutic functions into one platform, and prepare nanocomposite preparations that combine diagnosis and treatment. It has played an increasingly important role in cancer treatment and is a research hotspot in the world today. and frontier areas. [0003] In recent years, traditional treatment methods such as surgery, chemo...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K47/64A61K41/00A61K45/00A61K51/08A61P35/00B82Y5/00B82Y20/00B82Y25/00B82Y30/00B82Y40/00
CPCA61K47/64A61K51/08A61K45/00B82Y5/00B82Y20/00B82Y25/00B82Y30/00B82Y40/00A61P35/00A61K41/0052A61K41/0028A61K41/0057
Inventor 吴爱国李彦莹李娟
Owner CIXI INST OF BIOMEDICAL ENG NINGBO INST OF MATERIALS TECH & ENG CHINESE ACAD OF SCI
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