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Inhibitors of advanced glycosylation end products

A compound and alkyl technology, applied in the field of inhibitors of advanced glycation end products, can solve problems such as lack of consensus

Pending Publication Date: 2022-05-13
プラエテゴインコーポレイテッド
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, there is no consensus on the relative importance of different possible pathogenic mechanisms that may lead to these diabetic complications

Method used

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  • Inhibitors of advanced glycosylation end products
  • Inhibitors of advanced glycosylation end products
  • Inhibitors of advanced glycosylation end products

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[0218] Preparation of Compounds of the Invention

[0219] The compounds and methods of the invention will be better understood in conjunction with the following synthetic schemes, which illustrate ways in which the compounds of the invention can be prepared. Starting materials can be obtained from commercial sources or prepared by established literature methods known to those of ordinary skill in the art.

[0220] The reactions are performed in solvents appropriate to the reagents and materials employed and are suitable for the transformations being effected. Those skilled in the art of organic synthesis will understand that the functional groups present on the molecule should be consistent with the proposed transformation. This will sometimes require judgment to modify the order of synthetic steps or to choose one particular process scheme over another in order to obtain the desired compounds of the invention.

[0221] It will also be recognized that another major considera...

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Abstract

The present invention provides compounds of formula wherein A, B, G, R2, R6 and X are as defined herein, pharmaceutical compositions thereof, and methods for treating or inhibiting the development of AGE and / or ALE-related complications in a subject in need thereof, and pharmaceutical compositions thereof, and methods for treating or inhibiting the development of AGE and / or ALE-related complications in a subject in need thereof

Description

[0001] Cross References to Related Applications [0002] This application claims the benefit of priority to U.S. Provisional Patent Application No. 62 / 881,607, filed August 1, 2019, and U.S. Provisional Patent Application No. 63 / 006,706, filed April 7, 2020, both of which are incorporated by reference incorporated in its entirety. technical field [0003] This application relates to the fields of chemistry, medicine, nephrology, vascular disease, hyperlipidemia, hyperglycemia, advanced glycation end products, diabetic complications and advanced lipid oxidation end products. Background technique [0004] Advanced glycation end products (AGEs) are carbohydrate-derived chemical modifications and crosslinks that accumulate in long-lived tissue proteins during normal aging. Increased rates of AGE accumulation during hyperglycemia are associated with the development of long-term complications of diabetes including, but not limited to, retinopathy, nephropathy, neuropathy, atheros...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07D401/04C07D401/14C07D213/65C07D213/38C07D233/64A61K31/55A61K31/4439A61K31/5377A61K31/496A61P27/02A61P13/12A61P25/00A61P3/06A61P9/10A61P9/00A61P25/28A61P19/02A61P3/04A61P9/12A61P37/06A61P13/00
CPCC07D401/04C07D401/14C07D213/65C07D213/38C07D233/64A61P27/02A61P13/12A61P25/00A61P3/06A61P9/10A61P9/00A61P25/28A61P19/02A61P3/04A61P9/12A61P37/06A61P13/00C07D403/10C07D401/06A61P3/00A61P3/10A61K31/4439A61K31/5377A61K31/496A61K31/55C07D401/10
Inventor 拉贾·G·哈利法
Owner プラエテゴインコーポレイテッド