Compound amoxicillin and colistin sulfate suspension injection and preparation method thereof

A technology of amoxicillin sulfate and suspension injection, which is applied in the direction of antibacterial drugs, pharmaceutical formulations, liquid delivery, etc., can solve the problems of poor needle penetration and poor stability due to sedimentation, achieve improved drug dissolution, low cost, Effects on reducing stress and pain in animals

Pending Publication Date: 2022-05-27
四川恒通动保生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The object of the present invention is to provide a kind of compound amoxicillin sulfate colistin suspension injection and preparation method thereof, be used to solve the poor stability, sedimentation and hardening of amoxicillin sulfate colistin suspension in the prior art, and Poorly targeted technical issues

Method used

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  • Compound amoxicillin and colistin sulfate suspension injection and preparation method thereof
  • Compound amoxicillin and colistin sulfate suspension injection and preparation method thereof
  • Compound amoxicillin and colistin sulfate suspension injection and preparation method thereof

Examples

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Effect test

Embodiment 1

[0030] A compound amoxicillin colistin sulfate suspension injection, comprising the following raw materials proportioned by parts by weight: 11 parts of amoxicillin raw materials, 1 part of colistin sulfate raw materials, and suspending agent monooleic acid glycerin 3 parts esters, antioxidants - a mixture of methyl and propyl parabens 0.7 parts, dispersing agent 3 parts polyglycerol oleate, dispersing medium - ethyl oleate, soybean oil and medium chain glycerides 81.3 parts of the mixture;

[0031] Wherein, the mass ratio of methylparaben and propylparaben in the mixture of methylparaben and propylparaben is 8:1; the mixture of ethyl oleate, soybean oil and medium chain glyceride The mass ratio of ethyl oleate, soybean oil and medium chain glyceride was 1:1:1.

[0032] A preparation method of compound amoxicillin colistin sulfate suspension injection, comprising the following steps:

[0033] Step (1): mix the dispersing medium, suspending agent and antioxidant evenly, add A...

Embodiment 2

[0037] A compound amoxicillin colistin sulfate suspension injection, comprising the following raw materials proportioned by parts by weight: 9 parts of amoxicillin raw materials, 2 parts of colistin sulfate raw materials, and suspending agent oleoyl polyoxygen Ethylene Glycerides 4 Parts, Antioxidant - Mixture of Methylparaben and Propylparaben 0.5 Parts, Dispersing Agent Polyglyceryl Oleate 2 Parts, Dispersing Medium - Ethyl Oleate, Soybean Oil and Medium Chain Glycerin 82.5 parts of a mixture of acid esters;

[0038] Wherein, the mass ratio of methylparaben and propylparaben in the mixture of methylparaben and propylparaben is 5:1; the mixture of ethyl oleate, soybean oil and medium chain glyceride The mass ratio of ethyl oleate, soybean oil and medium chain glyceride was 2:1:1.

[0039] Example 2 The preparation method of Compound Amoxicillin Colistin Sulfate Suspension Injection is the same as Example 1.

Embodiment 3

[0041] A compound amoxicillin-colistin sulfate suspension injection, comprising the following raw materials in proportion by weight: 10 parts of amoxicillin raw materials, 1.5 parts of colistin sulfate raw materials, and suspending agent oleoyl polyoxygen 2 parts of ethylene glyceride, 0.7 parts of antioxidant vitamin E, 3 parts of dispersant polyglycerol oleate, 82.8 parts of dispersion medium - a mixture of ethyl oleate, soybean oil and medium chain glyceride;

[0042] Wherein, the mass ratio of ethyl oleate, soybean oil and medium chain glyceride in the mixture of ethyl oleate, soybean oil and medium chain glyceride is 2:1:2.

[0043] Example 3 The preparation method of Compound Amoxicillin Colistin Sulfate Suspension Injection is the same as Example 1.

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Abstract

The invention discloses a compound amoxicillin and colistin sulfate suspension injection, which is prepared from the following raw materials in parts by weight: 9 to 11 parts of amoxicillin raw material medicine, 1 to 2 parts of colistin sulfate raw material medicine, 2 to 5 parts of suspending aid, 0.5 to 1 part of antioxidant, 2 to 5 parts of dispersing agent and 79 to 95 parts of dispersing medium. The invention further discloses a preparation method of the compound amoxicillin and colistin sulfate suspension injection. According to the compound amoxicillin and colistin sulfate suspension injection prepared by the invention, through the synergistic interaction of the specific suspending aid and the dispersing agent, the drug dissolution rate is improved, meanwhile, the problems that the amoxicillin and colistin sulfate suspension injection is easy to settle and harden are solved, and the drug stability is improved.

Description

technical field [0001] The invention relates to the technical field of veterinary drugs, in particular to a compound amoxicillin colistin sulfate suspension injection and a preparation method thereof. Background technique [0002] Amoxicillin is a semi-synthetic penicillin antibiotic. It is a reproductive bactericide (Class I). It is a penicillin with an amino side chain, but it is several times more potent than penicillin. It is mainly used for infectious diseases of Gram-positive bacteria and some negative bacteria. Colistin sulfate is an alkaline polypeptide antibiotic, which mainly acts on bacterial cell membranes, prevents the infection of sensitive bacteria and promotes the growth of livestock and poultry. The function of ribosome makes it difficult for bacteria to develop resistance to it, and there is no cross-resistance with other antibiotics. [0003] The chemical properties of amoxicillin are unstable. When amoxicillin interacts with acid, alkali, hydroxylamine ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K38/12A61K31/43A61K9/10A61K47/14A61P31/04
CPCA61K38/12A61K31/43A61K9/10A61K9/0019A61K47/14A61P31/04A61K2300/00Y02A50/30
Inventor 张志阳刘起军吴洪黄恩龙
Owner 四川恒通动保生物科技有限公司
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