Pulse ultrasound and medicine synergistic in-vitro non-invasive therapeutic apparatus and operation method thereof

Abstract

The invention belongs to the technical field of medical equipment, and particularly discloses a pulsed ultrasound synergistic drug in-vitro non-invasive therapeutic apparatus and an operation method thereof.The pulsed ultrasound synergistic drug in-vitro non-invasive therapeutic apparatus comprises an ultrasound generation system, a drug monitoring system and a drug delivery system, the ultrasound generation system comprises an ultrasound generator and an ultrasound transducer, and the ultrasound transducer has a low-frequency gear and a high-frequency gear; the drug monitoring system is a reflective fluorescence imaging system, and is used for detecting the fluorescence intensity of drug-loaded nanoparticles by collecting fluorescence photons reflected by the drug-loaded nanoparticles marked by fluorescent substances in skin tissues so as to monitor the enrichment degree of drugs in focus tissues in a treatment area; the drug delivery system is combined with the drug monitoring system to realize precise controlled release of drugs. The therapeutic apparatus integrates ultrasonic medicine penetration, sonodynamic therapy and the like, in-vitro non-invasive treatment of tuberculosis lesions and accurate feeding, efficient controlled release and efficient sterilization of medicines are realized through cooperation of ultrasonic waves and the medicines, and formation of drug-resistant tubercle bacillus is prevented or drug resistance is reversed.

Description

technical field [0001] The invention relates to the technical field of medical equipment, in particular to the technical field of ultrasonic synergistic drug permeation therapy equipment, and in particular to an in vitro non-invasive therapeutic apparatus for pulsed ultrasonic synergistic drugs. Background technique [0002] Tuberculosis is the second largest infectious disease in the world after HIV caused by Mycobacterium tuberculosis (MTB). latent infection. WHO estimates that my country accounts for about a quarter of the world's multidrug-resistant tuberculosis patients, and lists my country as one of the 25 key countries for the prevention and control of drug-resistant tuberculosis in the world. According to the statistics of the World Health Organization, in 2017, there were about 1.7 billion people with latent tuberculosis infection in the world, and 10.1 million new cases, of which China accounted for 8.9% of the world's new cases and 37,000 deaths. Drug resistanc...

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Problems solved by technology

[0009] In view of the above-mentioned shortcoming of the prior art, the object of the present invention is to provide a kind of pulsed ultrasound in conjunction with drug in vitro non-invasive treatment instrument, for solving the poor treatment effect of ultrasonic drug penetration device in the prior art, and Mycobacterium tuberculosis ( MTB), macrophages (Mф) hypotonic drug characteristics lead to problems such as clinical treatment can not reach the effective drug concentration to kill mycobacteria

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