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Cell culture chamber with improved cell contact surface

A cell culture, cell contact technology that can be used in cell culture supports/coatings, tissue culture, general culture methods, etc., and can solve problems such as commercialization barriers, high manufacturing costs, etc.

Pending Publication Date: 2022-07-08
OCTANE BIOTECH +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although cell therapy holds great promise in the clinic, the high manufacturing cost relative to reimbursement is a huge barrier to commercialization

Method used

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  • Cell culture chamber with improved cell contact surface
  • Cell culture chamber with improved cell contact surface
  • Cell culture chamber with improved cell contact surface

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0120] Example 1 is a cell culture chamber for use in an automated cell engineering system, the cell culture chamber comprising: a flat and inflexible chamber having a low chamber height; and a cell contacting surface wherein the At least a portion of the cell-contacting surface includes a non-porous gas permeable material.

Embodiment 2

[0121] Embodiment 2 includes the cell culture chamber of embodiment 1, wherein the cell culture chamber further comprises at least one of: a distal port configured to allow removal from the cell culture chamber A bubble and / or configured as a recirculation port; an intermediate port configured to function as a recirculation inlet port; and a proximal port configured to function as a drain port for cell removal.

Embodiment 3

[0122] Embodiment 3 comprises the cell culture chamber of embodiment 1 or embodiment 2, wherein the cell contacting surface comprises a plurality of separate segments, each segment comprising the non-porous gas permeable material.

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Abstract

The present disclosure provides cell culture chambers for use in automated cell engineering systems, and in particular cell culture chambers comprising improved cell contact surfaces. The improved cell-contacting surface may comprise: a surface coating that promotes cell growth, adhesion, differentiation, phenotypic maintenance, and / or improves transduction; a cell contacting surface, the cell contacting surface comprising a non-porous breathable material; and other modifications to the cell contact surface. A cartridge comprising the cell culture chamber is also provided.

Description

[0001] CROSS-REFERENCE TO RELATED APPLICATIONS [0002] This application claims the benefit of US Provisional Patent Application No. 62 / 925,392, filed October 24, 2019, the disclosure of which is incorporated herein by reference in its entirety. technical field [0003] The present disclosure provides cell culture chambers for use in automated cell engineering systems, and in particular, cell culture chambers comprising improved cell contact surfaces. The improved cell-contacting surface may comprise: a surface coating that promotes cell growth, adhesion, differentiation, phenotype maintenance and / or improved transduction; a cell-contacting surface comprising a non-porous breathable materials; and other modifications to the cell-contacting surface. A cassette comprising the cell culture chamber is also provided. Background technique [0004] In anticipation of establishing accelerated clinical adoption of advanced cell therapies, more attention is turning to basic manufact...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C12M1/00
CPCC12M23/24C12M41/48C12M23/04C12M23/20C12M23/42C12M41/12C12M29/20C12N2533/52C12M27/00C12M41/34C12M41/32C12M29/24C12N5/0068G01N35/1009
Inventor N·特雷纳E·亚伯拉罕T·史密斯M·休伊特Y·施K·珀普拉C·麦克罗比
Owner OCTANE BIOTECH