Tilmicosin solution and preparation method thereof
A technology of tilmicosin and solution, which is applied in the direction of pharmaceutical formulations, medical preparations with non-active ingredients, medical preparations containing active ingredients, etc., which can solve the problem of affecting product quality storage and subsequent use, and water and oil are not miscible, etc. problems, to avoid affecting the palatability, the water quality requirements are not high, and the effect of maintaining stability
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Example Embodiment
[0022] Example 1:
[0023] The invention provides a preparation method of tilmicosin solution, comprising the following steps:
[0024] S1. Take 2g of hypromellose with a viscosity of 3mPa·s and add it to 10ml of purified water, and the temperature is controlled at 55~65℃ and stirred until it is completely dissolved to obtain solution A;
[0025] S2. Dissolve 0.2g of sodium alginate in 10ml of purified water with a temperature of 25°C, and then add 10g of tilmicosin for mixed liquid grinding until it becomes a uniform milky white liquid to obtain solution B;
[0026] S3. First add solution B to solution A for mixed liquid grinding, add an appropriate amount of purified water to the mixed solution 100ml during the liquid grinding process, and continue the mixed liquid grinding until the solution is clear to obtain a tilmicosin solution.
Example Embodiment
[0027] Example 2:
[0028] The invention provides a preparation method of tilmicosin solution, comprising the following steps:
[0029] S1. Take 2g of hypromellose with a viscosity of 3mPa·s and add it to 10ml of purified water, and the temperature is controlled at 55~65℃ and stirred until it is completely dissolved to obtain solution A;
[0030] S2. Dissolve 0.2g of alginic acid sulfate in 10ml of purified water with a temperature of 25°C, and then add 10g of tilmicosin for mixed liquid grinding until it becomes a uniform milky white liquid to obtain solution B;
[0031] S3. First add solution B to solution A for mixed liquid grinding, add an appropriate amount of purified water to the mixed solution 100ml during the liquid grinding process, and continue the mixed liquid grinding until the solution is clear to obtain a tilmicosin solution.
Example Embodiment
[0032] Example 3:
[0033] The invention provides a preparation method of tilmicosin solution, comprising the following steps:
[0034] S1. Take 2g of hypromellose with a viscosity of 3mPa·s and add it to 10ml of purified water, and the temperature is controlled at 55~65℃ and stirred until it is completely dissolved to obtain solution A;
[0035] S2. Dissolve 0.2 g of fucoidan diester sodium in 10 ml of purified water with a temperature of 25 °C, then add 10 g of tilmicosin to mix the liquid and mill until it becomes a uniform milky white liquid, to obtain solution B;
[0036] S3. First add solution B to solution A for mixed liquid grinding, add an appropriate amount of purified water to the mixed solution 100ml during the liquid grinding process, and continue the mixed liquid grinding until the solution is clear to obtain a tilmicosin solution.
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Abstract
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Application Information
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