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Tilmicosin solution and preparation method thereof

A technology of tilmicosin and solution, which is applied in the direction of pharmaceutical formulations, medical preparations with non-active ingredients, medical preparations containing active ingredients, etc., which can solve the problem of affecting product quality storage and subsequent use, and water and oil are not miscible, etc. problems, to avoid affecting the palatability, the water quality requirements are not high, and the effect of maintaining stability

Active Publication Date: 2022-07-29
SHANDONG GUOBANG PHARMA +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although the prepared tilmicosin solution is an O / W type molecular microemulsion, which has good water solubility, but because its water and oil are not miscible, stratification is still inevitable after long-term storage, which affects the quality and storage of products. Subsequent use

Method used

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  • Tilmicosin solution and preparation method thereof
  • Tilmicosin solution and preparation method thereof
  • Tilmicosin solution and preparation method thereof

Examples

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Effect test

Embodiment 1

[0023] The invention provides a preparation method of tilmicosin solution, comprising the following steps:

[0024] S1. Take 2g of hypromellose with a viscosity of 3mPa·s and add it to 10ml of purified water, and the temperature is controlled at 55~65℃ and stirred until it is completely dissolved to obtain solution A;

[0025] S2. Dissolve 0.2g of sodium alginate in 10ml of purified water with a temperature of 25°C, and then add 10g of tilmicosin for mixed liquid grinding until it becomes a uniform milky white liquid to obtain solution B;

[0026] S3. First add solution B to solution A for mixed liquid grinding, add an appropriate amount of purified water to the mixed solution 100ml during the liquid grinding process, and continue the mixed liquid grinding until the solution is clear to obtain a tilmicosin solution.

Embodiment 2

[0028] The invention provides a preparation method of tilmicosin solution, comprising the following steps:

[0029] S1. Take 2g of hypromellose with a viscosity of 3mPa·s and add it to 10ml of purified water, and the temperature is controlled at 55~65℃ and stirred until it is completely dissolved to obtain solution A;

[0030] S2. Dissolve 0.2g of alginic acid sulfate in 10ml of purified water with a temperature of 25°C, and then add 10g of tilmicosin for mixed liquid grinding until it becomes a uniform milky white liquid to obtain solution B;

[0031] S3. First add solution B to solution A for mixed liquid grinding, add an appropriate amount of purified water to the mixed solution 100ml during the liquid grinding process, and continue the mixed liquid grinding until the solution is clear to obtain a tilmicosin solution.

Embodiment 3

[0033] The invention provides a preparation method of tilmicosin solution, comprising the following steps:

[0034] S1. Take 2g of hypromellose with a viscosity of 3mPa·s and add it to 10ml of purified water, and the temperature is controlled at 55~65℃ and stirred until it is completely dissolved to obtain solution A;

[0035] S2. Dissolve 0.2 g of fucoidan diester sodium in 10 ml of purified water with a temperature of 25 °C, then add 10 g of tilmicosin to mix the liquid and mill until it becomes a uniform milky white liquid, to obtain solution B;

[0036] S3. First add solution B to solution A for mixed liquid grinding, add an appropriate amount of purified water to the mixed solution 100ml during the liquid grinding process, and continue the mixed liquid grinding until the solution is clear to obtain a tilmicosin solution.

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Abstract

The invention provides a tilmicosin solution and a preparation method thereof, and solves the technical problems that the existing tilmicosin solution is inevitably layered after being stored for a long time, and the quality guarantee storage and subsequent use of a product are influenced. The tilmicosin solution is prepared from the following raw materials in parts by weight: 1-2 parts of hydroxypropyl methylcellulose, 0.1-0.2 part of a raw material A, 8-12 parts of tilmicosin and a proper amount of purified water; wherein the viscosity of the hydroxypropyl methylcellulose ranges from 3 mPas to 2000 mPas; the raw material A is one of sodium alginate, sulfate alginate and sodium alginate polysaccharide diester; the invention further discloses a preparation method of the tilmicosin solution. The invention can be widely applied to the technical field of pharmaceutical preparations.

Description

technical field [0001] The application relates to the technical field of pharmaceutical preparations, in particular to a tilmicosin solution and a preparation method thereof. Background technique [0002] Since the Ministry of Agriculture issued an announcement in 2020 to prohibit the addition of antibiotics in feed, the use of antibiotics in large livestock farms has generally been converted to drinking water. Tilmicosin is a semi-synthetic macrolide antibiotic specially used for livestock and poultry. It is generally prepared by semi-synthesis of tylosin. Mycoplasma and spirochetes have inhibitory effects, and are mainly used to treat infectious diseases caused by sensitive bacteria in livestock such as cattle, goats, sheep, dairy cows, pigs, chickens, etc., especially the treatment of respiratory tract infections in livestock and poultry is more effective. Because tilmicosin is extremely difficult to dissolve in water, it has a strong bitter taste, which affects the pala...

Claims

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Application Information

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IPC IPC(8): A61K9/08A61K31/706A61K47/38A61K47/61A61P31/04
CPCA61K31/706A61K47/61A61K9/08A61K47/38A61P31/04Y02A50/30
Inventor 付程丽廖仕学于童
Owner SHANDONG GUOBANG PHARMA
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