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Salvia miltiorrhiza-radix puerariae loaded nanofiber hydrogel dressing and preparation process thereof

A nanofiber and preparation process technology, applied in medical science, bandages, etc., can solve the problem of not having the ability to promote wound healing, and achieve the effects of inhibiting platelet aggregation, promoting the formation of bone cells, and expanding coronary vascular activity.

Pending Publication Date: 2022-07-29
QINGDAO UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Aiming at the deficiencies in the prior art, the present invention provides a nanofiber hydrogel dressing loaded with Danshen-Pudzu root and its preparation process, which solves the problem that traditional hydrogel dressings do not have the ability to promote wound healing

Method used

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  • Salvia miltiorrhiza-radix puerariae loaded nanofiber hydrogel dressing and preparation process thereof
  • Salvia miltiorrhiza-radix puerariae loaded nanofiber hydrogel dressing and preparation process thereof
  • Salvia miltiorrhiza-radix puerariae loaded nanofiber hydrogel dressing and preparation process thereof

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Experimental program
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Embodiment 1

[0023] The embodiment of the present invention provides a nanofiber hydrogel dressing loaded with Salvia miltiorrhiza-pueraria, comprising the following raw materials in parts by weight: 50 parts of pueraria, 50 parts of Salvia miltiorrhiza, 30 parts of photocrosslinking agent and 80 parts of MeGel aqueous solution.

[0024] The photocrosslinker was 33 ul / ml of 1.5% (w / v) Irgacure 2959 / 70% in ethanol and 10% MeGel in water.

[0025] A preparation process of a nanofiber hydrogel dressing containing Salvia miltiorrhiza-pueraria, comprising the following steps:

[0026] S1. Drug Extraction

[0027] First, put Pueraria lobata and Salvia miltiorrhiza into a grinder and grind them into powder. Put Pueraria lobata and Salvia miltiorrhiza powder in a mixing tank at a weight ratio of 1:1 and stir them continuously for 10 minutes at a speed of 150 r / min until they are evenly mixed. , take 500g of mixed powder, put the powder into the beaker, add a small amount of water to the beaker an...

Embodiment 2

[0032] An embodiment of the present invention provides a nanofiber hydrogel dressing loaded with Salvia miltiorrhiza-pueraria, comprising the following raw materials in parts by weight: 40 parts of pueraria, 40 parts of Salvia miltiorrhiza, 20 parts of photocrosslinking agent and 60 parts of MeGel aqueous solution.

[0033] The photocrosslinker was 33 ul / ml of 1.5% (w / v) Irgacure 2959 / 70% in ethanol and 10% MeGel in water.

[0034] A preparation process of a nanofiber hydrogel dressing containing Salvia miltiorrhiza-pueraria, comprising the following steps:

[0035] S1. Drug Extraction

[0036]First, put the kudzu root and salvia miltiorrhiza into a grinder and grind them into powder. Put the kudzu root powder and salvia miltiorrhiza powder into the mixing tank according to the weight ratio of 1:1 and stir, and continue to stir at a speed of 100r / min for 5 minutes until the mixture is uniform. , take 500g of mixed powder, put the powder into the beaker, add a small amount of ...

Embodiment 3

[0041] The embodiment of the present invention provides a kind of related index monitoring of a nanofiber hydrogel dressing containing Salvia miltiorrhiza-pueraria,

[0042] 1) Microstructure characterization

[0043] Structural features of hydrogel dressings were observed using scanning electron microscopy, such as image 3 shown, where (A a) is a microscopic image of the surface and cross-section of a 0% MeGel hydrogel dressing, (B b) is a microscopic image of the surface and cross-section of a 5% MeGel hydrogel dressing, and (C c) is a 10% MeGel hydrogel dressing. Microscopic images of the surface and cross-section of the adhesive dressing. From the electron microscope image of the surface, the existence of fibrous structure can be seen. In the cross-section electron microscope image, the porous structure of hydrogel and the layered state of nanofiber membrane can be clearly observed. Therefore, it can be considered that the radially oriented nanofiber membrane and the dru...

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Abstract

The invention provides a nanofiber hydrogel dressing loaded with radix salviae miltiorrhizae and radix puerariae and a preparation process of the nanofiber hydrogel dressing, and relates to the technical field of hydrogel dressings. The nanofiber hydrogel dressing loaded with the radix salviae miltiorrhizae-radix puerariae is prepared from the following raw materials in parts by weight: 40 to 50 parts of radix puerariae, 40 to 50 parts of radix salviae miltiorrhizae, 20 to 30 parts of photo-crosslinking agent and 60 to 80 parts of MeGel aqueous solution. Compounds extracted from radix salviae miltiorrhizae and radix puerariae comprise puerarin, daidzein, cryptotanshinone, dihydrotanshinone, tanshinone I and the like, the puerarin can expand blood vessels, blood flow of the brain and the heart can be increased and circulation can be improved by expanding heart and blood vessels and brain blood vessels, and a medicine solution in hydrogel has the effect of promoting blood circulation. Under the action of the loose and porous hydrogel structure and the internal and external osmotic pressure difference, the medicine is rapidly released, healing of the wound surface is promoted, the nanofiber membrane hydrogel dressing has a good healing effect on the diabetic wound surface, the healing effect is better than the self-healing effect, and epidermis formation of the wound surface is promoted.

Description

technical field [0001] The invention relates to the technical field of hydrogel dressings, in particular to a nanofiber hydrogel dressing containing Salvia miltiorrhiza and Pueraria lobata and a preparation process thereof. Background technique [0002] Hydrogel dressings, also known as hydrocolloid dressings, are commonly used clinical wound dressings. The most common one is carboxymethyl cellulose sodium (CMC) synthetic elastomer, which can absorb wound exudate and maintain the moistness and sealing of the wound surface. Thereby providing a good healing environment for wounds, which can be used for the prevention and treatment of phlebitis, as well as superficial ulcer wounds. [0003] At present, traditional hydrogel dressings can only cover the wound surface, and the wound heals itself, but does not have the ability to promote wound healing. SUMMARY OF THE INVENTION [0004] In view of the deficiencies of the prior art, the present invention provides a nanofiber hydro...

Claims

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Application Information

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IPC IPC(8): A61L26/00
CPCA61L26/008A61L26/0066A61L26/0038A61L26/0085A61L2300/30A61L2400/12A61L2300/412A61L2300/602
Inventor 赵文文陈修平吴韶华郑皓伊张梦瑶贺鹏
Owner QINGDAO UNIV