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Preparation method, product and application of whitening composition capable of improving solubility of active components

A technology of active components and compositions, which is applied in the field of preparation of whitening compositions, can solve problems such as emulsion breaking, impact effect, product instability, etc., and achieve the effects of improving solubility, increasing slow-release penetration, and improving emulsification effect

Pending Publication Date: 2022-08-09
上海肤徕生物高科技有限公司 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0004] However, although these natural sources of ferulic acid, azelaic acid, hesperidin and aescin have good effects, they are neither soluble in water nor oil, and their use is very limited, even if they are made into creams. It will break the emulsion due to precipitation, resulting in extremely unstable product, and ferulic acid is also easily oxidized, which affects its own function

Method used

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  • Preparation method, product and application of whitening composition capable of improving solubility of active components
  • Preparation method, product and application of whitening composition capable of improving solubility of active components
  • Preparation method, product and application of whitening composition capable of improving solubility of active components

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preparation example Construction

[0040] The preparation method of the whitening composition is:

[0041] 1. Mix azelaic acid, ferulic acid, dipropylene glycol and glycerin and heat to 60-70°C to completely dissolve to obtain composition 1;

[0042] 2. Mix glyceryl acetate, hesperidin, and aescin and heat to 60-70° C. to dissolve completely to obtain composition 2;

[0043] 3. Slowly add composition 1 to composition 2 at 60-70 °C, and stir while adding to obtain composition 3;

[0044] 4. Mix and heat water, mannose erythritol lipid, dipalmitoyl phosphatidyl choline, and lecithin to 60° C. and then homogenize until the lecithin is completely dissolved to obtain composition 4;

[0045] 5. Add composition 3 to composition 4, and homogenize at 10,000-15,000 r / s for 3-5 minutes to complete emulsification;

[0046] 6. Add the emulsified emulsion to a high-pressure homogenizer, and reflux under high pressure for 8-9 times at a pressure of 850 bar to prepare a whitening nano-emulsion.

Embodiment 1

[0048] The combination of the whitening nano-emulsion of the present invention is, in parts by mass of raw materials: 31 parts of azelaic acid, 14 parts of ferulic acid, 5 parts of hesperidin, 2 parts of aescin, and 5 parts of dipalmitoyl phosphatidylcholine. parts, 3 parts of lecithin (PC40), 1 part of mannose erythritol lipid, 5 parts of glycerol acetate, 12 parts of glycerin, dipropylene glycol (C 6 H 14 O3 ) 7 parts, water to 100 parts.

[0049] 1. Mix azelaic acid, ferulic acid, dipropylene glycol and glycerin and heat to 65°C to completely dissolve to obtain composition 1;

[0050] 2. Mix glyceryl acetate, hesperidin, and aescin and heat to 65° C. to dissolve completely to obtain composition 2;

[0051] 3. Slowly add composition 1 to composition 2 at 65°C, and stir while adding to obtain composition 3;

[0052] 4. Mix and heat water, mannose erythritol lipid, dipalmitoyl phosphatidyl choline and lecithin to 60°C and homogenize until the lecithin is completely dissolve...

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Abstract

The invention discloses a preparation method, a product and application of a whitening composition capable of improving solubility of active components. The preparation method comprises the following steps: mixing azelaic acid, ferulic acid, dipropylene glycol and glycerol, and heating to obtain a composition 1; mixing glyceryl acetate, hesperidin and escin, and heating to obtain a composition 2; slowly adding the composition 1 into the composition 2 while stirring to obtain a composition 3; mixing water, mannosyleryl lipid, dipalmitoyl phosphatidylcholine and lecithin, heating, and homogenizing until the lecithin is completely dissolved to obtain a composition 4; adding the composition 3 into the composition 4, and homogenizing and stirring until the composition 3 is completely emulsified; and 5, adding the product obtained in the step 5 into a high-pressure homogenizer, and carrying out high-pressure refluxing. According to the preparation method, a nano-emulsion technology is adopted, a proper solvent, a proper emulsifier and the like are found to completely dissolve functional raw materials, and the nano-emulsion with uniform particle size is prepared and can be added into an aqueous product or an emulsified body.

Description

technical field [0001] The invention belongs to the technical field of cosmetics, and in particular relates to a preparation method of a whitening composition for improving the solubility of active components, its product and application. Background technique [0002] At present, there are more and more whitening raw materials and whitening cosmetics on the market. Many consumers will have symptoms such as ineffective or sensitive skin after using whitening products. A safe and effective whitening is still an urgent problem to be solved. [0003] Ferulic acid is derived from Chinese herbal medicines such as Angelica sinensis. It is a very safe and effective whitening ingredient. It can not only inhibit the activity of melanocyte B16V, but also inhibit the activity of tyrosinase. It also has oxygen free radical scavenging and good antioxidant effects. . In addition, ferulic acid also has the effect of absorbing ultraviolet sunscreen. Azelaic acid can competitively inhibit t...

Claims

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Application Information

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IPC IPC(8): A61K8/63A61K8/34A61K8/36A61K8/362A61K8/37A61K8/55A61K8/60A61Q19/00A61Q19/02
CPCA61K8/36A61K8/602A61K8/362A61K8/63A61K8/553A61K8/345A61K8/375A61K8/60A61Q19/02A61Q19/00A61K2800/5922Y02A50/30
Inventor 陈凤凤杨钰澍
Owner 上海肤徕生物高科技有限公司
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