Internal cavitary and vessel stent with medicinal coating against spinal canal restenosis and production thereof

A technology of drug coating and inner stent, which is applied in the direction of drug devices, coatings, and other medical devices. Effective treatment, inhibition of smooth muscle cell proliferation and platelet aggregation, and promotion of vascular re-endothelialization

Inactive Publication Date: 2005-03-30
XIYUAN HOSPITAL OF CHINA ACAD OF CHINESE MEDICAL SCI
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, these drugs can inhibit the re-endothelialization of blood vessels, affect the healing process of vascular injury, and may thin the vessel wall and even form hemangiomas.
On the other hand, the coated stents of the above drugs are expensive, each about 40,000 yuan

Method used

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  • Internal cavitary and vessel stent with medicinal coating against spinal canal restenosis and production thereof
  • Internal cavitary and vessel stent with medicinal coating against spinal canal restenosis and production thereof
  • Internal cavitary and vessel stent with medicinal coating against spinal canal restenosis and production thereof

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Embodiment Construction

[0038] seefigure 1 , a kind of intraluminal intraluminal stent with anti-restenosis drug coating of the present invention is made up of stent 1 and drug coating 2 covered on the surface of stent 1, wherein the drug coating is turmeric containing curcumin (curcumin) Layer 3. see figure 2 , the stent in the body cavity of the present embodiment is made in the following manner: first, pour 150 mg of curcumin into 1.5 ml of absolute ethanol, and mix well to make a curcumin drug solution; then, take a body cavity Put the stent into the curcumin drug solution, take it out after dipping for 60 seconds; dry it with nitrogen; then place the stent in the curcumin drug solution, take it out after immersion for 20 seconds; then blow it dry with nitrogen . In this way, the intraluminal stent in the body with the anti-restenosis drug coating of this embodiment is manufactured.

[0039] During the manufacturing process of the stent in the body lumen of this embodiment, the number of time...

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Abstract

An inner scaffold with the coated medicine for preventing and treating re-stenosis of cavity tract is composed of the main body of scaffold and the coated medicine including curcumin. It features that said coated medicine can be slowly released to suppress the reproduction of smooth muscle cells and the synthesis of extracellular matrix and resist blood coagulation and inflammation. It is especially for the plastic operation of transcortical arteria coronaria.

Description

technical field [0001] The invention relates to a stent with a drug coating for preventing and treating restenosis and a manufacturing method thereof. Specifically, the present invention proposes a therapeutic stent that uses the stent as the skeleton and the coating as the eluting carrier to locally administer medicine to the lumen of the lesion, and a method for manufacturing the stent of the present invention according to the characteristics of the drug used. Background technique [0002] Percutaneous transluminal coronary angioplasty (PTCA) is the mainstay of treatment for intraluminal stenotic diseases in vivo. In this method, the tubular stent is percutaneously implanted into the body lumen (such as blood vessels, etc.), and the mechanical properties of the stent are used to expand the stenotic lesion to the required cross-section, so as to meet the needs of the human body. cycle needs. For more than 20 years, this technology has been developed rapidly, and has been ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61F2/04A61L27/28A61M29/00A61M31/00
Inventor 涂秀华冯新庆徐铭渔
Owner XIYUAN HOSPITAL OF CHINA ACAD OF CHINESE MEDICAL SCI
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