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Liquid medicine for stent, medicine eluting stent and preparation method of medicine eluting stent

A technology of eluting stents and drug solutions, applied in the field of eluting stents, can solve the problems of uneven release of coating drug doses and large single drug doses, and achieve the effects of accelerating vascular endothelial repair, enhancing function, and reducing vascular inflammation

Inactive Publication Date: 2021-08-24
HARBIN MEDICAL UNIVERSITY +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In addition, problems such as uneven release of coating drug doses and large single drug doses will cause corresponding complications

Method used

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  • Liquid medicine for stent, medicine eluting stent and preparation method of medicine eluting stent

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0045] This embodiment provides a drug-eluting stent 100, which is prepared through the following steps:

[0046] S1: Put the weighed granulocyte colony-stimulating factor, rapamycin, and polylactic acid into a volumetric flask, immerse it in an organic solvent, and let it stand for four hours to make the granulocyte colony-stimulating factor, rapamycin, and polylactic acid After the lactic acid is fully dissolved, the stent drug solution 103 is obtained;

[0047] S2: Use an organic solvent to make up the volume, and use a syringe to draw the medicinal solution from the volumetric flask to filter, and pass the filtered medicinal solution 103 for the stent into a dry and clean volumetric flask for use;

[0048] S3: Turn on the 100-level laminar flow table and run it for ten minutes;

[0049] S4: Turn on the power supply of the sprayer, the ultrasonic power supply and the constant-current pump. After the nitrogen meter on the sprayer is stable, discharge the solvent liquid pre-...

Embodiment 2

[0052] This embodiment provides a drug-eluting stent 100, which is prepared through the following steps:

[0053] S1: Put the weighed granulocyte colony-stimulating factor, rapamycin, and polylactic acid into a volumetric flask, immerse it in an organic solvent and let it stand for four and a half hours to make the granulocyte colony-stimulating factor, rapamycin And the stent drug solution 103 is obtained after the polylactic acid is fully dissolved;

[0054] S2: Use an organic solvent to make up the volume, and use a syringe to draw the medicinal solution from the volumetric flask to filter, and pass the filtered medicinal solution 103 for the stent into a dry and clean volumetric flask for use;

[0055] S3: Turn on the 100-level laminar flow platform and run it for 20 minutes;

[0056] S4: Turn on the power supply of the sprayer, the ultrasonic power supply and the constant-current pump. After the nitrogen meter on the sprayer is stable, discharge the solvent liquid pre-in...

Embodiment 3

[0059] This embodiment provides a drug-eluting stent 100, which is prepared through the following steps:

[0060] S1: Put the weighed granulocyte colony-stimulating factor, rapamycin, and polylactic acid into a volumetric flask, immerse it in an organic solvent, and let it stand for five hours to make the granulocyte colony-stimulating factor, rapamycin, and polylactic acid After the lactic acid is fully dissolved, the stent drug solution 103 is obtained;

[0061] S2: Use an organic solvent to make up the volume, and use a syringe to draw the medicinal solution from the volumetric flask to filter, and pass the filtered medicinal solution 103 for the stent into a dry and clean volumetric flask for use;

[0062] S3: Turn on the 100-level laminar flow platform and run it for 30 minutes;

[0063] S4: Turn on the power supply of the sprayer, the ultrasonic power supply and the constant-current pump. After the nitrogen meter on the sprayer is stable, discharge the solvent liquid pr...

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Abstract

The invention discloses liquid medicine for a stent, a medicine eluting stent and a preparation method of the medicine eluting stent, and relates to the technical field of elution stents. The liquid medicine for the stent comprises the following components in percentage by weight: 0.01 to 0.4 percent of granulocyte colony stimulating factor, 0.5 to 1.7 percent of rapamycin, 0.7 to 4.0 percent of polylactic acid and the balance of organic solvent. The liquid medicine for the scaffold can be combined with specific receptors on the surfaces of granulocyte progenitor cells and mature neutrophils through reasonable proportioning of granulocyte colony stimulating factors G-CSF, rapamycin, polylactic acid and acetone, promotes proliferation and differentiation of the granulocyte progenitor cells and the mature neutrophils, enhances the functions of the mature neutrophils, can promote proliferation, differentiation and maturation of medullary hematopoietic progenitor cells, and can adjust proliferation and differentiation maturation of the neutrophil line; the neutrophile granulocytes can be driven to be released to the blood flow, so that the number of peripheral neutrophile granulocytes is increased; EPCs can be mobilized to enter peripheral blood, injured vascular endothelium repair is accelerated, vascular inflammation can be reduced, and ISR can be effectively controlled.

Description

technical field [0001] The invention relates to the technical field of eluting stents, in particular to a drug solution for stents, a drug-eluting stent and a preparation method thereof. Background technique [0002] Coronary heart disease has always been a global health problem that plagues mankind. With the rapid development of interventional surgery for coronary heart disease, percutaneous coronary intervention (PCI) has become an important treatment for coronary artery stenosis, which can significantly improve the clinical symptoms and prognosis of patients with coronary heart disease. "Milestone" in medical treatment of coronary heart disease. [0003] With the innovation of drugs and technologies, the use of perioperative antithrombotic therapy, new generation of antiplatelet drugs, and new drug-eluting stents, the prognosis of patients with stent implantation has improved significantly in the short to medium term, and there is still a risk of stent failure, and Spec...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L31/08A61L31/10A61L31/16A61F2/915
CPCA61L31/08A61L31/10A61L31/16A61F2/915A61L2300/41A61L2300/606A61L2300/252A61L2300/404A61F2002/91575A61F2250/0067C08L67/04
Inventor 于波张海琴贾海波候静波代建南邢磊
Owner HARBIN MEDICAL UNIVERSITY
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