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Gene preparations

A technology of genes and preparations, applied in the field of preparations containing genes, can solve problems such as difficult implementation

Inactive Publication Date: 2005-12-07
KOKEN CO LTD +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] In addition, a method capable of repeated administration is desired because such a method is difficult to implement in gene therapy using viral vectors and the like

Method used

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Examples

Experimental program
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Effect test

example 1

[0054] 0.9ml contains 10 9 pfu (plaque forming unit) inserted into the gene encoding fibroblast growth factor HST-1 (FGF4) (as disclosed in Proc. Natl. Acad. Sci. USA, 84 , 2980-2984 (1987)) adenovirus (Adex1 HST-1; Proe.Natl.Acad.Sci.USA, Vol. 91 , 12368 (1994)) was mixed with 0.1 ml of a neutral solution of hypoplastic collagen (hypoplastic collagen implants prepared by KOKEN: 2% hypoplastic collagen solution) to prepare a genetic preparation. The above-mentioned adenovirus (Adex1 HST-1) can be as disclosed in J.Virol., 54 , 711-719 (1985) or Proc.Natl.Acad.Sci.USA, 93 , 1320 (1996) and Cell, 13 , 181-188 (1978), inserting the fibroblast growth factor HST-1 gene into the non-proliferating adenovirus gene by deleting the E1A, E1B and E3 portions of adenovirus type 5 (ATCC catalog number VR-5) obtained in.

example 2

[0056] Mix 0.1 ml of 2% incomplete collagen neutral solution with 0.9 ml containing 10 9 The medium of pfu Adex1 HST-1 was mixed to prepare a gel-type gene preparation, and the mixture was then kept at 37°C.

example 3

[0058] A gene preparation was prepared by the following method: freeze-drying the incomplete collagen neutral solution to obtain a sponge; cut the sponge into squares of about 5 mm; add the cut sponge to 1 ml containing 10 9 In the medium of pfu Adex1 HST-1, the sponge rested overnight.

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Abstract

The present invention relates to gene preparations comprising desired genes or vectors containing desired genes integrated there into and carriers for supporting the same.

Description

Field of Invention [0001] The present invention relates to the field of medicine, in particular to the field of gene therapy. More specifically, the present invention relates to a gene-containing formulation. After administration to a living body, the preparation can stably hold the gene vector or gene, release it gradually and maintain the therapeutic effect over a long period of time. The formulation can discontinue treatment within a favorable time. Background of the Invention [0002] Gene therapy is an active area of ​​research, and expectations for successful treatments are extremely high. In gene therapy, where the genes themselves are medicines, the treatment of diseases is carried out by transferring genes such as selected enzymes, cytokines, etc., into the cells of the patient. The introduced gene then produces a specific substance in the patient's body. Such gene therapy can be divided into two categories. The first category is intended to provide semi-perman...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K48/00
CPCA61K48/00
Inventor 寺田雅昭落谷孝广宫田晖夫伊藤博
Owner KOKEN CO LTD
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