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Method for making biologic composite materials of nanometer hydroxyapatite/polyamide series for medical use

A technology of nano-hydroxyapatite and composite materials, applied in medical science, prosthesis, etc., can solve problems such as low output, difficult process control, and expensive solvents

Inactive Publication Date: 2005-12-07
SICHUAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Due to the high reaction temperature of this preparation method, the polyamide will be oxidized and discolored when the temperature is too high during the dissolution process, the process control is difficult, and the solvent is expensive, and the entire compounding process takes a long time (about 9 hours for the compounding process). Li Yubao et al. In "Reno, Nevada, USA" April 30-May 3, 2003: 596, the in-situ co-precipitation method was introduced to prepare composite materials. First, Ca(NO 3 ) 2 Dissolve in acetamide solution, and then dissolve polyamide 66 in it under the condition of heating at 140°C, and finally add Na 3 PO 4 , in situ generation of homogeneously dispersed needle-like nano-hydroxyapatite crystals in polyamide 66 in acetamide solution, but in low yield

Method used

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  • Method for making biologic composite materials of nanometer hydroxyapatite/polyamide series for medical use
  • Method for making biologic composite materials of nanometer hydroxyapatite/polyamide series for medical use
  • Method for making biologic composite materials of nanometer hydroxyapatite/polyamide series for medical use

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022]Dissolve 15 grams of calcium chloride in 150 ml of methanol solvent, add 15 grams of polyamide 66, and dissolve at 55°C under stirring. The nano-hydroxyapatite slurry is prepared by the above-mentioned "J.Mater.Sci.: Mater.in Med." 5 (1994): 252-255 literature report of wet synthesis and hydrothermal treatment (moisture content 66%), Weigh 29.4 grams of the slurry, mix 1.5 grams of polyethylene glycol 6000 and 50 ml of methanol into the slurry and stir well. The water-containing methanol slurry of nano-hydroxyapatite is slowly added in the calcium chloride / methanol solution of polyamide 66, and at a temperature of 55 ° C, it is kept fully stirred for 2 hours to obtain nano-hydroxyapatite / polyamide 66 (weight The ratio is 4 / 6) composite material. All reagents used were of analytical grade (AR). The reacted product mixture was precipitated in deionized water, washed 6 times with hot deionized water and 2 times with absolute ethanol, dried at 100°C, and ground for later u...

Embodiment 2

[0024] The polyamide material was changed to polyamide 6, and the nano-hydroxyapatite slurry and other operating methods and conditions were the same as those in Example 1 to obtain a nano-hydroxyapatite / polyamide 6 (weight ratio of 4 / 6) composite material.

Embodiment 3

[0026] Take 25 grams of calcium chloride and dissolve it in 150 ml of methanol solvent, add 30 grams of polyamide 66, and dissolve at 50°C under stirring. The preparation method of nano-hydroxyapatite slurry is the same as that in Example 1. Weigh 22.05 grams of slurry (water content 66%), mix 1.2 grams of polyethylene glycol 6000 and 40 ml of methanol into the slurry and stir. Slowly add the calcium chloride / methanol solution of polyamide 66 into the aqueous methanol slurry of nano-hydroxyapatite, and fully stir for 1 hour at a temperature of 60° C. to prepare nano-hydroxyapatite / polyamide 66 ( 20 / 80) composite material. All reagents used were of analytical grade (AR).

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Abstract

The invention relates to a process for preparing nano hydroxyapatite / polyamide series biological medical composite material by using polyamides component and nano hydroxyapatite as raw material, wherein the weight ration of polyamides / nano hydroxyapatite is 8 / 2-2 / 8, through the steps of, dissolving polyamides into methanol solution, mixing nano hydroxyapatite into nano hydroxyapatite slurry consisting polyethylene glycol and water or methanol solution containing water, mixing the two for recombination while stirring, water sedimentation of the obtained product, washing with hot-water and anhydrous alcohol respectively.

Description

technical field [0001] The invention relates to a method for preparing nanoscale apatite / polyamide series biomedical composite materials under normal pressure and mild conditions. Background technique [0002] For biomedical composite materials used for bone replacement, in order to increase the content of hydroxyapatite in the composite material and ensure that the composite material has better biological activity, nano-hydroxyapatite and polymer composites can be used. In "Biomaterials" 2001, 22(13): 1705-1711, Kikuchi M reported that Ca(OH) 2 and H 3 PO 4 Nano-hydroxyapatite crystals were self-assembled on porcine collagen, and then the composite material was cold isostatically pressed under a pressure of 200MPa to prepare biomimetic bone. In "Journal of Sol-Gel Science and Technology" 2001, 21 (1): 7-12, Nemoto R reported that a low-viscosity sol directly composited with nano-hydroxyapatite and silk protein was prepared by ball milling. In "Chinese Journal of Biomedi...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L27/44
Inventor 李玉宝左奕魏杰
Owner SICHUAN UNIV