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Konjaku gluocomannan-calcium alginate microball for carrying medicine and preparing method

A technology of konjac glucomannan and calcium alginate, which is applied in the direction of block transportation, etc., to achieve the effect of convenient and sustained release, improved drug sustained release performance, and mild conditions

Inactive Publication Date: 2006-02-15
TIANJIN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, konjac glucomannan and its oligosaccharides are mainly used as primary food raw materials or health products at home and abroad, and konjac glucomannan is rarely used as a drug sustained-release carrier

Method used

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  • Konjaku gluocomannan-calcium alginate microball for carrying medicine and preparing method
  • Konjaku gluocomannan-calcium alginate microball for carrying medicine and preparing method
  • Konjaku gluocomannan-calcium alginate microball for carrying medicine and preparing method

Examples

Experimental program
Comparison scheme
Effect test

example 1

[0020] Dissolve 2g sodium alginate in 100ml deionized water or dissolve 2g sodium alginate and 0.5g konjac glucomannan in 100ml deionized water, drop sodium alginate sol or mixed sol in the form of tiny droplets into the concentration of 0.2M Calcium alginate microspheres or konjac glucomannan-calcium alginate microspheres with smooth surface, uniform particle size and good sphericity ( figure 1 ). From the infrared absorption curve of konjac glucomannan-calcium alginate microspheres, it can be found that due to the weak hydrogen bond and electrostatic interaction between alginic acid and konjac glucomannan, Some absorption peaks in the curve disappeared or some new absorption peaks appeared ( figure 2 ).

example 2

[0022] Dissolve 2g sodium alginate and 0.5g konjac glucomannan in 100ml deionized water, drop the mixed sol into 0.2M CaCl in the form of tiny droplets 2 in water or CaCl 2 Concentration is 0.2M, chitosan concentration is 0.5% (w / v), chitosan molecular weight is 8.55×10 6 Calcium alginate-chitosan microspheres or konjac glucomannan-calcium alginate- Chitosan microspheres. From the infrared absorption curve of konjac glucomannan-calcium alginate-chitosan microspheres ( figure 2 ), most of the absorption peaks became weaker, which was mainly due to the multiple interactions between alginic acid, konjac glucomannan and chitosan. In addition, the structure of the microsphere gel without adding konjac glucomannan and adding konjac glucomannan was significantly different ( image 3 , Figure 4 ), which is mainly due to the filling of konjac glucomannan and the multiple interactions between alginic acid, konjac glucomannan and chitosan.

example 3

[0024] Dissolve 2g sodium alginate and 0.5g konjac glucomannan in 100ml deionized water, drop the mixed sol into CaCl in the form of tiny droplets 2 The concentration is 0.2M, the chitosan concentration is 0.25% (w / v), and the molecular weight is 5.87×10 6 in the chitosan calcium chloride solution, gel for 30 minutes, filter and wash, and konjac glucomannan-calcium alginate-chitosan microspheres with a smaller molecular weight of chitosan can be obtained.

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Abstract

The said microballoon is in single nuclear structure or in core-shell structure. The core material is composite of konjaku glucomannan and calcium alginate; and the shell material is chitosan-calcium alginate polyelectrolyte film. The preparation process includes dropping the mixed hydrosol of konjaku glucomannan-calcium alginate into the water solution of CaCl2 or chitosan-CaCl2; water washing and drying the microspherical matter to obtain konjaku glucomannan-calcium alginate or konjaku glucomannan-calcium alginate-chitosan microballoon. The present invention has the advantages of raised medicine slow releasing performance, easy control of medicine release, simple technological process, low production cost and easy scale production.

Description

technical field [0001] The invention relates to a konjac glucomannan-calcium alginate microsphere and a preparation method thereof, belonging to the preparation technology of the microsphere for drug loading. Background technique [0002] As a sustained-release drug material, natural polysaccharides have the characteristics of good biocompatibility and have been widely studied and applied. Alginic acid is an acidic polysaccharide extracted from brown algae. It consists of two structural units of guluronic acid (denoted as G segment) and its stereoisomer mannuronic acid (denoted as M segment) in three ways (ie MM segments, GG segments and MG segments) are linear block copolymers linked by α(1-4) glycosidic bonds. It can form a hydrogel in an aqueous solution of divalent metal ions, the preparation conditions are mild, and it is suitable for embedding active substances such as proteins, enzymes and cells. In addition, it has good biocompatibility and bioadhesion, so it has c...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/16A61K47/36
Inventor 何志敏王康何明霞
Owner TIANJIN UNIV
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