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Application of liganans of biphenyl cyelo-octadiene in preparing antineoplastic medicine

A biphenyl cyclooctadiene, tumor drug technology, applied in the direction of anti-tumor drugs, drug delivery, drug combination, etc.

Inactive Publication Date: 2006-11-15
普尔药物科技开发(深圳)有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In the process of studying the lignans in Tiejuopan, our laboratory isolated the biphenylcyclooctadiene lignan compound Schisantherin I (Schisandra I), and so far no activity reports about this compound have been seen.

Method used

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  • Application of liganans of biphenyl cyelo-octadiene in preparing antineoplastic medicine
  • Application of liganans of biphenyl cyelo-octadiene in preparing antineoplastic medicine
  • Application of liganans of biphenyl cyelo-octadiene in preparing antineoplastic medicine

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Embodiment Construction

[0016] The following examples help those skilled in the art to better understand the present invention, but do not limit the present invention in any way.

[0017] The pharmaceutical composition of the present invention contains a physiologically effective amount of biphenyl cyclooctene lignans and / or a pharmaceutically acceptable carrier, and the biphenyl cyclooctenyl lignans I is 1-hydroxyl-2,3 , 12,13,14-Pentamethoxy-6-hexanoate-7-hydroxy-8-methyl-9-benzoate-biphenylcyclooctadiene lignan.

[0018] The above pharmaceutical composition can be applied to the preparation of drugs for treating and / or preventing tumors.

[0019] The above biphenyl cyclooctene lignans can be applied to the preparation of drugs for the treatment and / or prevention of tumors, and the biphenyl cyclooctene compounds are 1-hydroxy-2,3,12,13,14-pentamethoxy -6-hexanoate-7-hydroxy-8-methyl-9-benzoate-biphenylcyclooctadiene lignan.

[0020] The pharmaceutical composition of the present invention adopts p...

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Abstract

The present invention relates to the application of biphenyl cyclooctene lignans in the preparation of antitumor drugs. The compound is extracted from the root and stem of Schisandra propinqua (Wall.) Baill.] A biphenyl cyclooctene lignan (1-hydroxy-2,3,12,13,14-pentamethoxy-6-hexanoate-7-hydroxy-8-methyl-9-benzoic acid Ester-biphenylcyclooctadiene lignans), experimental studies have proved that they have cytotoxic effects on hematological tumors and solid tumors, and can induce tumor cell apoptosis and cell morphology and cell cycle arrest in G1 phase It is expected to develop its application in the clinical prevention and treatment of tumors.

Description

technical field [0001] The present invention relates to the cytotoxicity of biphenylcyclooctadiene lignan compound I isolated from the root and stem of Schisandra propinqua (Wall.) Baill.] to blood tumors and solid tumors The effect, the effect of inducing apoptosis, the effect of affecting the cell cycle and its application in the clinical prevention and treatment of tumors. Background technique [0002] Biphenylcyclooctadiene lignans are mainly derived from Schizandraceae plants in nature, and are the characteristic components of this family of plants. This type of lignans has a unique skeleton, complex stereochemistry, and extensive biological activities. In the 1970s, it was found in clinical research in my country that Schisandra chinensis could significantly reduce the level of serum trough aminotransferase SGPT in patients with hepatitis, which caused an upsurge in the study of Schisandra chinensis as a medicinal plant, and thus developed the drug bifendate for the tr...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/222A61K9/00A61P35/00
Inventor 陈新滋肖培根陈士林陈四保许利嘉
Owner 普尔药物科技开发(深圳)有限公司
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