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Appts. and processes for whole-body hyperthermia

A high-temperature, whole-body technology that can be used in therapy, electrotherapy, pharmaceutical formulations, etc., to solve problems such as death and zero mortality

Inactive Publication Date: 2001-05-09
维亚瑟克公司
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  • Claims
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Problems solved by technology

The overall mortality rate in this study was only 7%; if patients with abnormal lung conditions were excluded from the study, and patients with rare intracranial vascular conditions were not treated, the mortality rate would be zero
[0014] In the known documented extracorporeal heating of blood, there have been various difficulties including elevated serum transaminases and bilirubin, cases of nerve damage with serum hypophosphatemia due to abnormal pH or sodium, bicarbonate Risk of sodium or potassium levels, and possible death from necrosis of large tumors

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  • Appts. and processes for whole-body hyperthermia
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Embodiment Construction

[0055] Description of Preferred Embodiments

[0056] In order to assist in an understanding of the principles of the present invention, reference will be made to some of the embodiments therein, and specific code numbers will be used to represent the same. It should be understood that it is not intended to limit the scope of the present invention in any way, such as certain modifications, further modifications and applications of the principles of the present invention that are usually attempted by those skilled in the art to belong to the present invention.

[0057] The present invention enables sorbent-based hemodialysis for hyperthermia therapy in a highly effective manner. This hemodialysis technique involves the use of a special sorbent suspension as the hemodialysis solution. The dialysis method during hyperthermia treatment allows the regulation and maintenance of appropriate levels of various important electrolytes in the blood. In addition, multiple toxins, such as ...

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Abstract

Apparatuses for use in whole-body hypothermia include a high-flow hyperthermia circuit coupled to a low-flow dialysis circuit in a manner which reduces tensioning of membranes in the dialyzer (152) of the dialysis circuit. The arrangement thereby allows proper membrane movement to assist in mixing a sorbent suspension (176) circulated on the sorbent side of the dialyzer. Additional dialysis apparatuses include advantageous disposable packs (300) including the dialyzer (152), sorbent heat exchangers (186) arranged to cooperate with heating elements on base units of the apparatuses, and adaptations for very high flow rates useful in the hyperthermic treatment of cancers.

Description

Field of Invention [0001] The present invention relates to a special apparatus for whole body hyperthermia treatment including extracorporeal blood heating and dialysis. Background technique [0002] Systemic hyperthermia therapy (WBHT) has been carefully studied and used as a treatment for malignant hyperplasia since the 1960s (3, 4, 27). There have been many previous reports of tumor regression occurring concurrently with induced fever. Biochemical studies of the effects of hyperthermia have shown that temperatures above 41°C lead to necrosis of certain types of tumors (3, 5). In vivo, high temperature leads to tumor necrosis through specific physiological effects. In normal and tumor tissue, high temperature causes initial vasodilation of blood vessels to increase blood flow. Subsequently, blood flow is reduced due to autoregulation and vasoconstriction (6). Tumor tissue lacks the vascular responsiveness to autoregulate blood flow and is thus more prone than normal ti...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/08A61K33/06A61K33/14A61M1/16A61M1/34A61M1/36A61P43/00
CPCA61M2001/3493A61M1/3437A61M1/3458A61M2001/3458A61M1/166A61M2205/12A61M1/3493A61M2001/166A61M1/3621A61M1/369A61M2001/3437A61M1/26A61P43/00
Inventor S·R·阿斯
Owner 维亚瑟克公司
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