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Traditional Chinese medicine compound recipe for treating hyperplasia of mammary glands and preparation method thereof

A technology of mammary gland hyperplasia and quality control method, which is applied in the field of traditional Chinese medicine compound preparations for the treatment of mammary gland hyperplasia and its preparation, and can solve problems such as disease location limitations and blank Chinese patent medicines

Active Publication Date: 2007-03-21
YANTAI RONGCHANG PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Because the disease occurs locally, its disease location is relatively limited, and it is more suitable for external treatment, but there is still no Chinese patent medicine suitable for external treatment of this disease.

Method used

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  • Traditional Chinese medicine compound recipe for treating hyperplasia of mammary glands and preparation method thereof
  • Traditional Chinese medicine compound recipe for treating hyperplasia of mammary glands and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

experiment example 1

[0033] Experimental example 1: Design of extraction process route

[0034] This prescription was originally decocted in water for clinical use. It is effective in treating mammary gland hyperplasia, but the dosage is relatively large. Considering the anatomical structure characteristics of the disease, we changed it to an external preparation. Hesperidin, saikosaponin, peiminin, corydalin, angelica coumarin, prunerin, etc. are all alcohol-soluble ingredients, and according to the characteristics that the skin is easier to absorb alcohol-soluble ingredients, the extraction solvent is determined to be dilute ethanol.

[0035]Although Qingpi, Bupleurum, Sanleng, Curcuma, and Angelica dahurica contain volatile oils in the prescription, experiments have shown that it is difficult to obtain free volatile oils from other herbs except Curcuma. It is also less than one-thousandth, the extraction is meaningless, and the rate of water-soluble impurities is increased, which causes certai...

experiment example 2

[0041] Experimental example 2: Research on technical conditions of extraction process

[0042] Orthogonal Design Experiment

[0043] factor

[0044] Determination principle, method and experimental results of index components

[0045] In this test, the total saponins of Bupleurum is used as one of the result judgment indicators. Since the medicinal taste extracted from this prescription is composed of ten herbs and contains many impurities, 1% KH 2 PO 4 Wash with ammonia test solution to remove impurities and avoid negative interference.

[0046] The determination method of saikosaponin is as follows: Accurately weigh 1.00 mg of a standard product of saikosaponin a, dissolve it with ethanol and set the volume in a 10 ml volumetric flask as a standard solution. Take this standard solution, evaporate to dryness in a water bath at 70°C, add 0.1ml of 1% p-dimethylaminobenzaldehyde ethanol solution, warm in a water bath at 70°C for 10 minutes, take it out, add 4ml of p...

experiment example 3

[0053] Experimental example 3: Research on preparation molding process

[0054] 1. Comparative test of different dosages of polyvinyl alcohol (PVA05-88)

[0055] Dosage of PVA

Film-forming properties

Drug loading

30％

it is good

Big

40％

it is good

small

50％

it is good

small

[0056] The best dosage of PVA is 30%.

[0057] 2. Comparative test of different dosages of glycerin

[0058] Glycerin dosage

tenacity

Release condition

Drug content

10％

Difference

Difference

Big

15％

it is good

it is good

larger

20％

it is good

it is good

small

[0059] Glycerin is the best dosage with 15%.

[0060] 3. The use of polyvinylpyrrolidone (PVP): PVP has various characteristics and functions such as adhesion, thickening, suspension, dispersion, solubilization, complexation, and film formation. Adding a sm...

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PUM

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Abstract

The present invention discloses compound Chinese medicine preparation for treating hyperplasia of mammary glands and its preparation process and quality control method. The compound Chinese medicine is prepared with green tangerine orange peel, bupleurum root, fried cowherb seed, burreed rhizome, zedoary and other six kinds of Chinese medicinal materials, and through alcohol extraction, concentration, adding supplementary material, heating to dissolve and obtain extractum, painting, and stripping membrane as the adhered membrane. The present invention also provides the quality control method including component identification and content measurement. The membrane of the present invention has the functions of inhibiting hyperplasia, removing blood stasis, dissipating mass, relieving pain, lowering estradiol content in blood serum and plasma viscosity and reducing platelet aggregation and is effective medicine for hyperplasia.

Description

technical field [0001] The invention relates to a traditional Chinese medicine compound preparation, a preparation method thereof, and a quality control method, in particular to a traditional Chinese medicine compound preparation for treating mammary gland hyperplasia, a preparation method thereof, and a quality control method. Background technique [0002] Cystic hyperplasia of the breast is a general term for the main and interstitial chronic hyperplasia of the breast, also known as dysplasia of the breast, and belongs to the category of "breast addiction" and "breast nucleus" in Chinese medicine. The clinical symptoms are characterized by lumps and pain in the breast. It occurs in women aged 20 to 40, and occasionally occurs in men and children. The high incidence of this disease ranks first in breast diseases. The main method of modern medicine to treat this disease is to perform surgical resection for larger masses, but there is a possibility of recurrence after surger...

Claims

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Application Information

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IPC IPC(8): A61K36/906A61K36/902A61K36/8967A61K36/88A61K36/752A61K36/66A61K36/536A61K36/36A61K9/00A61P15/14
Inventor 胥云彭建中张永光滕云霞董江萍
Owner YANTAI RONGCHANG PHARMA
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