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Chinese medicine composition for deep fungus infection

A technology of deep fungus and composition, which is applied in the direction of drug combination, pharmaceutical formula, medical preparations containing active ingredients, etc. It can solve the problems of thrombophlebitis, poor absorption, and difficulty, and achieve strong antibacterial effect and broad antibacterial spectrum , less toxic and side effects

Inactive Publication Date: 2004-09-22
THE SECOND HOSPITAL OF HEBEI MEDICAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Miconazole is poorly absorbed orally and does not easily pass through the blood-brain barrier, so it is mostly administered intravenously, and intravenous administration can often lead to thrombophlebitis
Fluconazole is only effective against some Candida infections, and is naturally resistant to Candida krusei and Candida glabrata, and is not effective against Aspergillus infections

Method used

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  • Chinese medicine composition for deep fungus infection

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0078] Embodiment 1: prepare the capsule preparation of medicine of the present invention

[0079] Add 1000g of cinnamon powder and 1000g of Huoxiang, add 10 times of water, heat and reflux for 6 hours, and then distill, collect 500g of cinnamon aldehyde and 500g of Huoxiang oil, weigh 300g of cinnamon aldehyde and 240g of Huoxiang oil, mix them evenly, add 600g of dextrin, mix All, pack into capsules by 0.5g / grain, measure content, every capsule contains 0.25g cinnamon aldehyde, 0.20g patchouli oil.

[0080] Usage and dosage: Oral three times a day, 4-6 capsules each time.

Embodiment 2

[0081] Embodiment 2: prepare the injection of medicine of the present invention

[0082] Prepare cinnamaldehyde 300g, Huoxiang oil 300g by the method for embodiment 1. Weigh 150g of cinnamic aldehyde and 80g of Huoxiang oil, add appropriate amount of sodium chloride to adjust the osmotic pressure, add appropriate amount of Tween-80 to make it all dissolve, measure the content, make each ml injection contain 0.046g of cinnamic aldehyde, and filter 0.024g of Huoxiang oil , Potting, 100ml / bottle, sterilized at 100°C for 30 minutes.

[0083] Usage and dosage: intravenous infusion, once a day, 100ml each time.

[0084] The injection of the present invention has obtained substantially the same experimental results as the oral preparation in in vitro experiments and clinical observations.

Embodiment 3-6

[0086] The method for preparing cinnamon aldehyde and patchouli oil is the same as in Example 1, and clove oil is prepared by distillation. The consumption proportion of its raw material is different from embodiment 1, 2, but all can reach the effect described in the present invention.

[0087]

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Abstract

A Chinese medicine in the form of capsule, softgel, injection, or eyedrops for treating deep fungus infection is prepared from cinnamal (7-32 wt. portions) and agastache oil (8-32). Its advantages are high antibacterial function, broad spectrum and low toxic by-effect.

Description

technical field [0001] The present invention relates to medical formulations, in particular pharmaceutical compositions for the treatment of deep fungal infections. Background technique [0002] Fungal infections can be divided into superficial infections and deep infections. Superficial infections mostly occur in the fingernails, skin, vagina, and oral cavity. They are easy to observe, and there are many types of drugs for treatment, and the curative effect is also remarkable. Deep infections mostly occur in internal organs and deep tissues such as the lungs, brain, and digestive tract. The pathogenic bacteria are mainly Candida (such as Candida albicans, Candida tropicalis, Candida krusei, Candida glabrata, etc.), followed by Aspergillus (such as Aspergillus fumigatus, Aspergillus flavus, Qing mildew, etc.). Most of the deep fungal infections are secondary infections, and there are few types of therapeutic drugs, poor curative effect, and severe side effects. In recent...

Claims

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Application Information

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IPC IPC(8): A61K31/10A61P17/00
Inventor 王刚生
Owner THE SECOND HOSPITAL OF HEBEI MEDICAL UNIV
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