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Aconitum kusnezoffii methylsine aerosol and its preparation method

A technology of sulfamethoxazole and aerosol, which is applied in the directions of aerosol delivery, anti-inflammatory agent, non-central analgesic, etc., can solve the problems of slow onset, poor patient compliance, and inability to relieve pain quickly, and achieve stable Good sex, strong anti-inflammatory and analgesic effect, rapid analgesic effect

Inactive Publication Date: 2004-10-13
KUNMING ZIJIAN BIOTECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although it overcomes the above-mentioned deficiencies, it has the defects of slow onset of action and poor patient compliance such as mouth numbness when taking it orally, and it cannot provide rapid pain relief for sprains or contusions of limbs and muscles.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0052] formula:

[0053] Aconitin 0.2g

[0054] f 11 20000ml

[0055] Preparation process: under the condition of 10,000 grades, first dissolve aconitin in less than 10 times (2ml) of ethyl acetate, and pay attention to make it completely dissolved. Pay attention to make it dissolve completely, and produce it according to ordinary aerosol. Dispensed into 1000 vials of 20ml each

Embodiment 2

[0057]formula:

[0058] Aconitin 0.2g

[0059] Azone 2ml

[0060] f 12 20000ml

[0061] Preparation process: Under the condition of 10,000 grades, firstly dissolve the aconitin and Azone in 10 times less (2ml) ethyl acetate, and pay attention to make them completely dissolved. Pay attention to make it dissolve completely, and produce it according to ordinary aerosol. Dispensed into 1000 vials of 20ml each

Embodiment 3

[0063] formula:

[0064] Aconitin 0.2g

[0065] Azone 2ml

[0066] Muscone 0.5ml

[0067] Coumarin 1g

[0068] f 114 20000ml

[0069] Preparation process: Under the condition of 10,000 grades, firstly dissolve the aconitine, Azone, muscone, and coumarin in ethyl acetate less than 10 times (2ml), and pay attention to make them completely dissolved. Pay attention to make it dissolve completely, and produce it according to ordinary aerosol. Dispensed into 1000 vials of 20ml each.

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PUM

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Abstract

The present invention provides an aconitum kusnezoffii methylsine aerosol and its preparation method. Every ml contains 0.01-0.8 mg of aconitum kusnezoffii methylsine, it can be made into the pharmaceutically-aceptable aerosol, and it can use methol or camphor, etc. which is 0.05-10% of main medicine content as medial permeation p romotor, and can use coumarinic lactone or vanillin, etc. which is 0.002-5% of main medicine content as medical perfume. Said invention has good stability, can be stored for 4 years at normal temp., is small in irritation, can be quickly absorbed and can quickly produce action, and can be used for relieving inflammation and stopping pain obviously.

Description

technical field [0001] The invention relates to a bioactive aconitin aerosol and a preparation method thereof, belonging to pharmaceuticals. Background technique [0002] Aconitine A is a new alkaloid--Bulleyaconitine A isolated from the Ranunculaceae Aconitum plant Aconitum Bullyanum Diels. At present, the preparations of aconitin include injections, tablets, oral liquids, and soft capsules. The earliest developed is injection, which is clinically used to treat rheumatoid arthritis, rheumatoid arthritis, lumbar muscle strain, frozen shoulder, sprains of limbs, contusion, etc., and has good curative effect; it can also be used for cancer, surgery, etc. The pain produced; it has a certain curative effect on herpes zoster and so on. However, in the production of the injection, due to the insoluble and easily decomposed properties of aconitin, only organic solvents such as ethanol or propylene glycol can be used, which will bring severe pain to the patient during injection an...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/12A61K31/439A61P19/02A61P19/08A61P29/00
Inventor 赵勇
Owner KUNMING ZIJIAN BIOTECH
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