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Automatic liquid operation control system

A technology for manipulating systems and liquids, used in analytical materials, instruments, etc., to solve problems such as undetected dispensing tip removal, tip destruction, system damage, etc.

Inactive Publication Date: 2004-10-20
KOKI HLDG CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] A disadvantage of the automatic liquid handling system disclosed in Japanese Patent Application Laid-Open No. 2001-59848 is that it is not possible to conduct a large number of experiments with a single dispensing tip
As a result, allocation operations may be performed for undesired wells, or may not be performed for desired wells
Furthermore, after the tip removal operation, it is not detected whether all dispensing tips have been successfully removed from the head
Thus, when one or more dispensing tips accidentally remain in the head after a tip removal operation, a subsequent dispensing tip installation operation is performed on a head in which some of the dispensing tips are left unremoved, resulting in damage to the tips or damage to the tips. system damage

Method used

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Embodiment Construction

[0022] Preferred embodiments of the present invention will be described in detail with reference to the accompanying drawings. Fig. 1 shows an automatic liquid handling system 1 according to a preferred embodiment of the present invention. Figure 2 shows the arrangement of each container contained in the main body 2 of the automatic liquid handling system 1 seen from above. The automatic liquid handling system 1 includes a main body 2 and a control device 3 connected together by a communication cable 4 such as a LAN (Local Area Network) cable. A general-purpose personal computer is used as the control device 3 . The main body 2 of the automatic liquid handling system 1 includes: a robot 5 capable of moving and stopping in 3D space; a dispensing head 6 arranged at the end of the robot 5; and a drive circuit 7 for driving according to conditions input into the control device 3 Subject 2.

[0023] The robot has three orthogonal axes X, Y and Z, and can be moved to predetermine...

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Abstract

In order to eliminate any mistakes regarding attachment or removal of dispensing tips to and from a dispensing head provided in an automatic liquid handling system used for dispensing an object to be examined, reagent, enzymes or the like into wells of a microplate, a dispensing tip sensor is provided to sense if the dispensing tips are attached to the head. The sensor includes a light emitting unit and a light receiving unit which are disposed above and diagonally opposite positions of a disposal container in which used dispensing tips are disposed of. The dispensing head with some dispensing tips attached thereto moves to traverse the light path of the sensor, thereby enabling sensing of the dispensing tips attached to the head.

Description

technical field [0001] The present invention relates to an automated fluid handling system, for example, for dispensing objects to be examined, reagents or enzymes used in drug metabolism tests. Background technique [0002] Dispensing of reagents and the like to subjects to be examined is often performed not only in drug metabolism tests but also in other tests. Each trial involves a lot of work, and any errors due to human error must be eliminated. For this purpose, human operations tend to be replaced by automatic mechanical operations. In robotic operations, any errors in attaching and detaching the dispensing tip to and from the dispensing head must be eliminated. If such an error does eventually occur, it needs to be detected accurately. [0003] Japanese Patent Application Laid-Open No. 2001-59848 discloses an automatic liquid handling system including a three-dimensional mobile robot having a tip on which individual dispensing tips are detachably mounted. A senso...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N35/10
CPCG01N35/1011G01N2035/1013
Inventor 户井宽厚山田健二大泽秀隆大河原正
Owner KOKI HLDG CO LTD
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