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Method for extracting active arthritis resisting element from Capparis fruit

An effective part, anti-arthritis technology, applied in medical preparations containing active ingredients, anti-inflammatory agents, drug combinations, etc., can solve the problems of rheumatoid arthritis extraction and separation technology and related patents, and achieve significant pharmacological effects Effect

Inactive Publication Date: 2004-11-03
新疆维吾尔药业有限责任公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

After nearly 15 years of domestic and foreign patent searches for this invention, there is no extraction and separation technology and related patents related to the effective parts of the plant vine fruit in the treatment of rheumatoid arthritis

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] Crush 4 kg of vines of hammer fruit into 10 meshes, heat and reflux with 80 liters of 50% methanol, extract by cold soaking, extract 3 times, the extraction time is 2 hours, combine the extracts, and concentrate the extracts under reduced pressure at 40°C. Obtain the anti-arthritic crude extract of mallet fruit vine;

[0033] Degrease the crude extract extract with petroleum ether first, and then elute the residue with ethyl acetate and n-butanol system to obtain acetic acid containing one or more kinds of palmitic acid or caffeic acid and caffeic aldehyde or protocatechuic aldehyde respectively. Effective parts of ethyl ester and effective parts of n-butanol;

[0034] Then the obtained effective parts of ethyl acetate and n-butanol are used alone or mixed with other medicines (including western medicine or traditional Chinese medicine) in any proportion to prepare rheumatoid arthritis, rheumatoid arthritis, gout, frozen shoulder and other diseases. drug application. ...

Embodiment 2

[0036] Crush 5 kg of vines of hammer fruit to 20 meshes, heat and reflux with 50 liters of 70% ethanol, extract by percolation, extract twice, the extraction time is 5 hours, combine the extracts, and concentrate the extracts under reduced pressure at 45°C. Obtain the anti-arthritic crude extract of mallet fruit vine;

[0037] Degrease the crude extract extract with petroleum ether first, and then elute the residue with ethyl acetate and n-butanol system to obtain acetic acid containing one or more kinds of palmitic acid or caffeic acid and caffeic aldehyde or protocatechuic aldehyde respectively. Effective parts of ethyl ester and effective parts of n-butanol;

[0038] Then the obtained effective parts of ethyl acetate and n-butanol are used alone or mixed with other medicines (including western medicine or traditional Chinese medicine) in any proportion to prepare rheumatoid arthritis, rheumatoid arthritis, gout, frozen shoulder and other diseases. drug application.

Embodiment 3

[0040] Crush 4.5 kg of vines of hammer fruit to 30 meshes, heat and reflux with 60 liters of 80% methanol, extract by cold soaking, extract once, and the extraction time is 10 hours, combine the extracts, and concentrate the extracts at 50°C under reduced pressure. Obtain the anti-arthritic crude extract of mallet fruit vine;

[0041] Degrease the crude extract extract with petroleum ether first, and then elute the residue with ethyl acetate and n-butanol system to obtain acetic acid containing one or more kinds of palmitic acid or caffeic acid and caffeic aldehyde or protocatechuic aldehyde respectively. Effective parts of ethyl ester and effective parts of n-butanol;

[0042] Then the obtained effective parts of ethyl acetate and n-butanol are used alone or mixed with other medicines (including western medicine or traditional Chinese medicine) in any proportion to prepare rheumatoid arthritis, rheumatoid arthritis, gout, frozen shoulder and other diseases. drug application....

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PUM

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Abstract

The process of extracting the effective component of caper fruit for treating arthritis includes crushing caper fruit, heating reflux, extraction, decompressing concentration to obtain coarse extractive; defatting the coarse extractive with petroleum ether, and eluting the residue with ethyl acetate and n-butanol system to obtain different effective components. Experiment shows the effective components has the functions of relieving pain, diminishing inflammation and inhibiting immunity, and may be used in treating rheumarthritis, rheumatoid arthritis, gout, frozen should, etc. The present invention provides new way for treating the said diseases.

Description

technical field [0001] The invention relates to a method for extracting anti-arthritic effective parts from the vine of the plant hammer fruit. Background technique [0002] Hammer fruit and vine fruit, also known as (mouse melon), is the fruit of Capparisspinosa L, a plant of the genus Capparis in the family Capparis, also known as wild watermelon. Happily born in desert Gobi and rocky sandy soil on low hillsides. It is distributed in Xinjiang, Tibet and other places in my country. This product is oval, oblong or spherical, 2-4 cm long, 1.5-3 cm wide, yellow-green to brownish-yellow on the surface; blunt round or truncated at the top. There are 5-7 longitudinal ribs as a whole, mostly inconspicuous, only evident at the lower end. The seeds are cohesive to each other, and the raised granular outline can be seen from the outside, and the peel and seeds are tightly bonded together. Folks have used hammer fruit vine fruit (mouse melon) for a long time t...

Claims

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Application Information

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IPC IPC(8): A61P19/02A61P19/06A61P29/00
Inventor 阿吉艾克拜尔·艾萨许伟吴韬廖立新
Owner 新疆维吾尔药业有限责任公司
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