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Preparing method for extracting matrine from kuh-seng

A technology of matrine and matrine, which is applied in the field of matrine extraction, can solve the problems of matrine separation process difficulties, failure to increase matrine yield, and unsafe production operations, so as to reduce the cost of matrine separation. Difficulty, shortening extraction time, and improving efficiency

Inactive Publication Date: 2005-02-23
陆春
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The existing problems of this technique are: the one, the efficiency of aqueous liquid extraction is low; Such as: sophocarpine) is reduced into matrine, like this, can not improve the yield of matrine on the one hand, make the separation process of follow-up matrine from total alkaloids of matrine on the other hand comparatively difficult, as this application selects 7 In fact, it is a process of repeated extraction and back-extraction, and the process is cumbersome; the third is to use organic solvent extraction and back-extraction for the purification of Sophora flavescens biological total alkaloids. High toxicity, production operation is not safe enough

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0014] Dry and crush 5 kg of Sophora flavescens roots produced in Northwest China, infiltrate with 60% ethanol, and place it for 3 to 5 hours. Put the infiltrated raw materials into a stainless steel multi-functional extraction tank, and use 11 times, 8 times, and 6 times respectively at 80°C. The amount of 60% ethanol was refluxed and extracted 3 times, the extracts were combined, and the residue was discarded;

[0015] Add granular activated carbon to the extract according to the ratio of extracting 7% of the total alkaloids of Sophora flavescens, and slowly add 80% hydrazine hydrate dropwise to the extract according to the ratio of 5% of the total alkaloids of Sophora flavescens for reduction reaction at 50°C , and react until the spots of oxymatrine and sophocarpine in it are checked by thin layer chromatography and disappear.

[0016] Concentrate the reaction solution obtained in the previous step into an extract with a double-effect evaporator, reclaim the ethanol, and d...

Embodiment 2

[0022] Dry and crush 5 kg of Sophora flavescens roots produced in Northwest China, infiltrate them with 70% ethanol, place them for 3 to 5 hours, put them into a stainless steel multifunctional extraction tank, and use 9 times, 6 times, and 4 times of 70 % ethanol was refluxed for 4 times, the extracts were combined, and the residue was discarded;

[0023] Add granular activated carbon to the extract according to the ratio of 3% of the total alkaloids of Sophora flavescens, and slowly add 80% hydrazine hydrate dropwise to the extract according to the ratio of 8% of the total alkaloids of Sophora flavescens for reduction reaction at 40°C , and react until the spots of oxymatrine and sophocarpine in it are checked by thin layer chromatography and disappear.

[0024] Use a double-effect evaporator to concentrate the reaction solution obtained in the previous step into an extract, reclaim ethanol, and dissolve the extract with 2% hydrochloric acid. The solution is too strong acidi...

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Abstract

A process for extracting sophocarpidine from flavescent sophora root includes such steps as reflux extracting in alcohol, strong reduction reaction between liquid extract and hydrazine hydrate under catalysis of activated carbon, concentrating, dissolving in diluted acid, adsorbing by strong-acidic cationic exchange resin, water washing, alkalizing, alcohol eluting, vacuum concentrating, dissolving, alkalizing, layering, removing lower solution layer, crystallizing to obtain coarse sophocarpidine, vacuum concentrating of mother liquid, chromatography, acetone eluting, recovering acetone to obtain coarse sophocarpidine, collecting the coarse sophocarpidine, and repeatedly crystallizing in acetone.

Description

technical field [0001] The invention relates to a method for extracting matrine from Sophora flavescens. Background technique [0002] Sophora flavescens is the dried root of the leguminous plant Sophora flavescens. The main components include oxymatrine, matrine, sophocarpine, sophoridine, aloperine, sophoramine, cytisine, isomatrine, etc. A variety of alkaloid ingredients. Modern pharmacological experiments and clinics have proved that the alkaloids of Sophora flavescens have various physiological activities, especially inhibiting hepatitis, viral myocarditis and tumors. Chinese patent application 03108063.4 announced "a production process for preparing matrine, oxymatrine and sophoridine from flavescens", wherein the extraction of matrine mainly includes the extraction and purification of total alkaloids of flavescens and matrine The two steps of separation and purification of ginseng from total alkaloids of matrine. The steps of extracting and purifying the total alka...

Claims

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Application Information

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IPC IPC(8): C07D455/00
Inventor 王萍曹晖
Owner 陆春
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