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Method and system for detecting biological chip by space phase modulation interference array

A space phase, biological chip technology, applied in the biological field, can solve problems such as complex structure, and achieve the effect of high detection efficiency and high sensitivity

Inactive Publication Date: 2005-03-02
TSINGHUA UNIV
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Problems solved by technology

However, the structure is complicated, and the frequency of the acousto-optic modulator is also required to be very stable

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  • Method and system for detecting biological chip by space phase modulation interference array
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  • Method and system for detecting biological chip by space phase modulation interference array

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Embodiment Construction

[0029] The method for detecting biochips using the spatial phase modulation interference array and the system for detecting biochips protected by the present invention will be described below in conjunction with the accompanying drawings.

[0030] The present invention consists of four parts: a biosensing unit based on array phase detection, an incident arm, a reflection arm and a signal processing unit, such as Figure 5 shown. Wherein, the biosensing unit is a surface plasmon resonance biosensor, including a right-angle or trapezoidal prism 51, a refractive index oil layer 52 placed on the bottom surface of the right-angled or trapezoidal prism 51, an array chip 53, and a sample pool 54 placed below the array chip 53 ; The incident arm is positioned at one side of the biosensing unit, and includes He-Ne laser 45, attenuator 46, pinhole aperture 47, collimator 48, polarizer 49 and rectangular aperture 50 in sequence; The reflective arm is located on the other side of the bio...

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Abstract

The invention relates to a method and system of adopting space phase modulation and interference array to detect the biochip, which belongs to biological technical field. The invention aims to overcome the deficiency of current technique and provides a new biochip detecting method and system, which can detect different volumes of DAN chips and protein chips dispense with mark and real-time achieve the information about the interaction of the biomolecules. The principle of the detection by space phase modulation and interference array is: the light reflected by the biosensor unit entering wallaston prism after combined by the one dimensional magnifying lens, the contained s ray and p ray which is polarizationdirection is divided into the two rays transmitting in different direction and realizing co-lightpath space phase modulation and interference in wallaston prism; the interference fringe being converted into electrical signal through the polarizer and imaging lens, the information of real-time phase change of the each unit on the array chip being acquired after processing and be offered to the biologist and medical scientists to parse.

Description

technical field [0001] The invention belongs to the field of biotechnology, and particularly relates to a detection method and special equipment for realizing high-throughput detection of protein-protein, protein-effector, protein-DNA, DNA-DNA, ligand-receptor and other interactions. Background technique [0002] Biochips came out in the early 1990s and are developing into an important technology platform for life sciences. At present, biochips mainly include DNA chips (also known as gene chips) and protein chips. The DNA chip is based on the hybridization principle of complementary single-stranded DNA, and is detected by fluorescent labeling; the protein chip is based on the specific reaction of protein capture molecule "accessories", and now mainly uses fluorescent labeling. For DNA, it is relatively stable, and the labeling method has little effect on the detection accuracy, but it is more troublesome. Proteins are not the case. Not only is it troublesome to label, but ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N21/25G01N21/84G01N33/50
CPCG01N21/45G01N21/553
Inventor 余兴龙王鼎新魏星刘俊峰
Owner TSINGHUA UNIV
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