Apparatus for predicting stereostructure of protein and prediction method

Abstract

A three-dimensional structure of a protein is predicted by reproducing turns. An amino-acid-sequence read-in unit (110) reads in an amino-acid sequence as a primary sequence, and a secondary-structure prediction unit (130) predicts secondary structures corresponding to the amino-acid sequence. In a three-dimensional-structure prediction unit (200), a turn-forming-portion calculation means (210) calculates the number of amino acids forming the turn based on the predicted secondary structures. In a turn-information DB (230), information on structures of probable turns is registered, where the information is obtained according to secondary structures and the numbers of amino acids. The turn prediction means (220) searches for information on a structure of a probable turn, based on the secondary structures and the calculated number of the amino acids, and reproduces the turn based on the information which is searched for. A three-dimensional-structure reproduction means (240) reproduces the three-dimensional structure of the protein by using the reproduced turn.

Description

technical field [0001] The present invention relates to a device for predicting the three-dimensional structure of a protein and a method for predicting the same, in particular to a device for predicting the three-dimensional structure of a protein composed of amino acids based on an amino acid sequence and a method for predicting the same. Background technique [0002] Protein is a polypeptide composed of 20 amino acids bound by peptide bonds. In organisms, etc., polypeptides are generally folded in an ingenious manner, and polypeptides in which amino acids are arranged in a linear chain are folded to form complex three-dimensional structures of proteins. [0003] Here, the amino acid sequence of a straight-chain polypeptide is referred to as the primary sequence of a protein. The primary sequence of a protein indicates which amino acids are bonded by peptide bonds in what order, and the type and arrangement of the amino acid residues that make up the protein can be determ...

AI Technical Summary

Problems solved by technology

[0008] However, there is a problem with the technology of using the existing homology modeling method to predict the three-dimensional structure of proteins: if the protein does not have an amino acid sequence similar to the protein whose three-dimensional structure is known, the three-dimensional structure of the protein cannot be analyzed. predict

Therefore, existing modeling programs for predicting the three-dimensional structure of proteins are not yet capable of determining turns, reproducing their structures

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