Sodium fructose diphosphate granule agent and its preparation method

A technology of sodium fructose diphosphate and granules, which is applied in the direction of block delivery, cardiovascular system diseases, drug combination, etc., and can solve problems such as slow absorption, large side effects, and inconvenient swallowing

Inactive Publication Date: 2005-08-10
FUKANGREN BIO PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, due to the shortcomings of the oral dosage forms already on the market, such as slow absorption, large side effects, bad taste, and inconvenient swallowing for the elderly and children, on the basis of sodium fructose diphosphate tablets and capsules, an effective new drug for the treatment of heart disease has been developed. The granule preparation has the advantages that the sodium fructose diphosphate granule is easily soluble in water, can be taken after mixing, is convenient to take, and has a simple preparation process and low cost

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0017] Element

[0018] Preparation method: the active ingredients of the drug and the auxiliary materials are passed through a 80-mesh sieve, and the amount of sodium fructose diphosphate, sugar powder, and sodium carboxymethyl cellulose is added and mixed evenly, and the soft material is made with 75% ethanol solution, and granulated with a 20-mesh sieve , dried at 60°C, granulated with a 18-mesh sieve, and obtained. The prepared granules are easily soluble in water and taste good when taken with water.

Embodiment 2

[0020] Element

[0021] sodium fructose diphosphate

[0022] Preparation method: the active ingredients of the drug and the auxiliary materials are respectively passed through a 80-mesh sieve, and the amount of sodium fructose diphosphate, powdered sugar, and methyl cellulose are added and mixed uniformly, and the soft material is made with 75% ethanol solution, granulated with a 20-mesh sieve, and 60 ℃ drying, 18-mesh sieve granulation, that is. The prepared granules are easily soluble in water and taste good when taken with water.

Embodiment 3

[0024] Element

[0025] The preparation method is the same as in Example 2.

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PUM

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Abstract

A medicine, fructose-sodium diphosphate, in the form of particles for treating heart diseases contains fructose-sodium diphosphate, diluent and suspending aid proportionally.

Description

Technical field: [0001] The invention relates to a pharmaceutical preparation, in particular to a sodium fructose diphosphate granule and a preparation method thereof, and provides a pharmaceutical preparation for treating angina pectoris, myocardial infarction and heart failure at the molecular level and a preparation method thereof. Background technique: [0002] Sodium fructose diphosphate (fructose sodium diphosphate, FDP, formerly known as 1,6-diphosphate fructose) is an important product of cell metabolism, exogenous fructose diphosphate can act on the cell membrane, by activating phosphofructokinase on the cell membrane, increasing Increase the concentration of high-energy phosphate bonds and adenosine triphosphate in cells, thereby promoting the influx of potassium ions, restoring the resting state of cells, increasing the content of diphosphoglycerate in red blood cells, inhibiting the release of oxygen free radicals and histamine, and benefiting shock, ischemia, and...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/16A61K31/70A61P9/04A61P9/10
Inventor 蔡金巧
Owner FUKANGREN BIO PHARMA
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