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Combination of medication of containing eucalyptol, limonene and alpha pinene and application

A composition, the technology of limonene, is applied in the directions of drug combination, medical preparation containing active ingredients, pharmaceutical formula, etc., to achieve the effects of feeling comfortable, quick effect and definite curative effect

Inactive Publication Date: 2005-08-31
BEIJING GRAND JOHAUM PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

There is no domestic report that the preparation made of a pharmaceutical composition containing eucalyptol, limonene and α-pinene is used as an expectorant and cough medicine and to promote the discharge of contrast media

Method used

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  • Combination of medication of containing eucalyptol, limonene and alpha pinene and application
  • Combination of medication of containing eucalyptol, limonene and alpha pinene and application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0017] Embodiment 1 Pharmaceutical research (taking enteric-coated soft capsules as an example)

[0018] 1. Production process research

[0019] See "Instructions with attached drawings": Figure 1 is a flow chart of the production process.

[0020] 2. Quality Research

[0021] 【Identification】Chemical methods are used to identify the three main components.

[0022] [Inspection] Determination of related substances according to gas chromatography (Appendix VE of Part Two of the Chinese Pharmacopoeia Edition in 2000). ,

[0023] Others should meet the relevant regulations under the capsule (Chinese Pharmacopoeia 2000 edition two appendix IE).

[0024] 【Content Determination】Determination according to gas chromatography (Chinese Pharmacopoeia 2000 edition two appendix VE).

Embodiment 2

[0025] Example 2 Pharmacology and Toxicology Research

[0026] 1. Oral administration of the drug LD 50 determination

[0027] Drugs: self-made by our company.

[0028] Animals: supplied by the Animal Center of the Chinese Academy of Medical Sciences, 18-22 grams of Kunming species, male and female, healthy mice.

[0029] Administration route: gavage.

[0030] Drug preparation: add normal saline to the drug after a little Tween-80 solubilization to prepare:

[0031] 0.22g / ml, 0.31g / ml, 0.49g / ml, 0.64g / ml, 0.92g / ml.

[0032] Observation period: two weeks.

[0033] LD 50 Determination method: modified Cole's method [5]

[0034] Before the formal experiment, a small number of animals were used to pre-test, and the range of lethal doses that caused 100% and 0% mortality was measured, and then the formal experiment was carried out. The mice fasted for 16 hours were randomly divided into five groups, and the weights were divided into five dose groups. The mice were intragas...

Embodiment 3

[0064] Embodiment 3 pharmacodynamic research

[0065] (1) expectorant effect:

[0066] 1. Phenol red method in mice confirmed that gavage or subcutaneous injection of the drug in mice can significantly increase the washout of phenol red in the respiratory tract of mice, and the effect is enhanced with the increase of the dose.

[0067] 2. Rat capillary sputum volume method: Experiments have proved that the drug can promote the secretion of respiratory secretions in rats, which is significantly different from that in the normal saline control group.

[0068] 3. Pilocarpine is a cholinergic drug, which has a strong secretion-promoting effect on the glandular tissue of the respiratory tract and salivary glands, and the drug can significantly increase the outflow of saliva in mice by intragastric administration of the drug.

[0069] 4. Effects on ciliary movement: The tracheal ciliary movement test method has been proved to improve the ciliary movement of the tracheal mucous memb...

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Abstract

A composite medicine for treating bronchitis, pneumonia, pulmonary abscess, bronchiectasis,e tc contains eucalyptus oil essence, lemonene, alpha-pinene, and medicinal auxiliary.

Description

technical field [0001] The present invention relates to a pharmaceutical composition of eucalyptol, limonene and α-pinene, in particular to the pharmaceutical composition and its application, which is preferentially used for the treatment of cough, anti-inflammation, and expectoration of respiratory diseases and the promotion of the discharge of contrast media. Background technique [0002] Respiratory diseases are common and frequently-occurring diseases, and phlegm plays an important role. This medicine is a better expectorant [1] , the expectorant effect is mainly manifested as: this drug can quickly dissolve mucus in the upper and lower respiratory tract mucosa, promote secretion, and actively stimulate the mucociliary movement, enhance the mucociliary removal function, and help expel sputum. Has anti-inflammatory and antibacterial effects. [0003] The three main components of the Chinese medicine eucalyptol, limonene and α-pinene are respectively derived from: eucalyp...

Claims

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Application Information

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IPC IPC(8): A61P11/00A61P11/10A61P11/14A61P43/00
Inventor 卢欲华
Owner BEIJING GRAND JOHAUM PHARMA CO LTD
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