Quick release Yuquan micropill

A Yuquan pellet and immediate release technology, applied in pharmaceutical formulations, metabolic diseases, bulk delivery, etc., can solve the problems of incomplete drug absorption, low bioavailability, and large dosage, and achieve easy storage and bioavailability. Highly effective and easy to use

Active Publication Date: 2005-10-19
ZHEJIANG HISUN PHARMA CO LTD +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, it has the disadvantages of low bioavailability, incomplete drug absorption, large dosage and thick, large, black appearance.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] Example 1: Research on Extraction Technology of Yuquan Pellets Dry Extract

[0025] 1.1 Study on the extraction process conditions of kudzu root, schisandra, licorice, trichosanthin, rehmannia glutinosa, and radices:

[0026] Because puerarin, the active ingredient in kudzu root in the prescription, A and B in Schisandra chinensis are more soluble in ethanol, the polysaccharides in Ophiopogon japonicus, Trichosanthum Fructus and Rehmannia glutinosa, and glycyrrhizic acid in licorice are all water-soluble. In order to maximize the use of the active ingredients of each herb, we considered that the first two were extracted with high-concentration alcohol, and the rest were decocted in water, and eight processes were designed. details as follows:

[0027] Process 1: decoct all the six herbs in water, the first time is 10 times the amount, 1 hour; the second time is 8 times the amount, 1 hour.

[0028] Process 2: All 30% alcohol extraction (V / V), 10 times the amount for th...

experiment example 2

[0121] Experimental example 2. The preparation method of Yuquan pellets

[0122] Take 17 kg each of kudzu root, schisandra chinensis and trichosanthum powder crushed into coarse powder, 17 kg of rehmannia glutinosa and cut into pieces, 5.7 kg of licorice crushed into coarse powder, 17 kg of Radix Ophiopogon japonicus tuber, put the pueraria root and schisandra chinensis into the extraction tank according to the final determination process, add 80 8 times (272 L) of % ethanol (V / V), heat and reflux for extraction for two hours, release the extract, re-add the same amount of 80% ethanol (V / V), heat and reflux for two hours. After the medicinal dregs are evaporated to dry ethanol, other medicinal materials are put in together, and 725.6L of 8 times of water is added respectively, and the extraction is performed for two hours, twice in total.

[0123] Combine the ethanol extract and water extract, reduce pressure, and concentrate to a solid content of about 16% (W / W). The resulti...

experiment example 3

[0124] Experimental Example 3. Preparation of Yuquan Micro-Pellets

[0125] Take 17 kg each of kudzu root, schisandra chinensis and trichosanthum powder crushed into coarse powder, 17 kg of rehmannia glutinosa and cut into pieces, 5.7 kg of licorice crushed into coarse powder, 17 kg of Radix Ophiopogon japonicus tuber, put the pueraria root and schisandra chinensis into the extraction tank according to the final determination process, add 80 8 times (272 L) of % ethanol (V / V), heat and reflux for extraction for two hours, release the extract, re-add the same amount of 80% ethanol (V / V), heat and reflux for two hours. After the medicinal dregs are evaporated to dry ethanol, other medicinal materials are put in together, and 725.6L of 8 times of water is added respectively, and the extraction is performed for two hours, twice in total.

[0126] Combine the ethanol extract and water extract, reduce pressure, and concentrate to a solid content of about 16% (W / W). The resulting ex...

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PUM

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Abstract

The present invention relates to one kind of diabetes treating quick releasing Yuquan micro pill and its preparation process. The Yuquan micro pill is prepared through heating and reflux extracting kudzu vine root and schisandra with alcohol; decocting the extracted residue together with trichosanthes root, ophiopogon root, licorice and rehmannia root and filtering; decompression concentrating the alcohol extract and water extract; spray drying to obtain dried extractum; throwing the dried extractum powder and microcrystalline cellulose in the weight ratio of 40-68 to 32-60 into fluidizing bed pelletizing and coating machine; spraying water solution of PVP to pelletize and round; collecting 30-60 mesh micro pill and coating. The quick releasing Yuquan micro pill of the present invention has fast acting, high bioavailability, less taken amount, high curative effect and other advantages.

Description

field of invention [0001] The invention relates to a traditional Chinese medicine preparation for treating diabetes, that is, a traditional Chinese medicine pellet preparation. Specifically, the invention relates to a quick-release Yuquan pellet for treating diabetes and a preparation method thereof. Background technique [0002] Diabetes is a common and frequently-occurring disease in the Department of Endocrinology, also known as adult-onset diabetes, which usually occurs after the age of 35 to 40, accounting for more than 90% of diabetic patients, and has gradually increased in recent years. Clinically, hyperglycemia is the main sign, and prolonged illness can cause damage to multiple systems throughout the body. It has the characteristics of refractory cure, high recurrence rate, life-long medication, many complications, and high mortality rate. [0003] Commonly used hypoglycemic western medicines cannot achieve comprehensive therapeutic effects due to their limited ef...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/16A61P3/10
Inventor 杨义芳乔艳红
Owner ZHEJIANG HISUN PHARMA CO LTD
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