Quick release Yuquan micropill
A Yuquan pellet and immediate release technology, applied in pharmaceutical formulations, metabolic diseases, bulk delivery, etc., can solve the problems of incomplete drug absorption, low bioavailability, and large dosage, and achieve easy storage and bioavailability. Highly effective and easy to use
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Embodiment 1
[0024] Example 1: Research on Extraction Technology of Yuquan Pellets Dry Extract
[0025] 1.1 Study on the extraction process conditions of kudzu root, schisandra, licorice, trichosanthin, rehmannia glutinosa, and radices:
[0026] Because puerarin, the active ingredient in kudzu root in the prescription, A and B in Schisandra chinensis are more soluble in ethanol, the polysaccharides in Ophiopogon japonicus, Trichosanthum Fructus and Rehmannia glutinosa, and glycyrrhizic acid in licorice are all water-soluble. In order to maximize the use of the active ingredients of each herb, we considered that the first two were extracted with high-concentration alcohol, and the rest were decocted in water, and eight processes were designed. details as follows:
[0027] Process 1: decoct all the six herbs in water, the first time is 10 times the amount, 1 hour; the second time is 8 times the amount, 1 hour.
[0028] Process 2: All 30% alcohol extraction (V / V), 10 times the amount for th...
experiment example 2
[0121] Experimental example 2. The preparation method of Yuquan pellets
[0122] Take 17 kg each of kudzu root, schisandra chinensis and trichosanthum powder crushed into coarse powder, 17 kg of rehmannia glutinosa and cut into pieces, 5.7 kg of licorice crushed into coarse powder, 17 kg of Radix Ophiopogon japonicus tuber, put the pueraria root and schisandra chinensis into the extraction tank according to the final determination process, add 80 8 times (272 L) of % ethanol (V / V), heat and reflux for extraction for two hours, release the extract, re-add the same amount of 80% ethanol (V / V), heat and reflux for two hours. After the medicinal dregs are evaporated to dry ethanol, other medicinal materials are put in together, and 725.6L of 8 times of water is added respectively, and the extraction is performed for two hours, twice in total.
[0123] Combine the ethanol extract and water extract, reduce pressure, and concentrate to a solid content of about 16% (W / W). The resulti...
experiment example 3
[0124] Experimental Example 3. Preparation of Yuquan Micro-Pellets
[0125] Take 17 kg each of kudzu root, schisandra chinensis and trichosanthum powder crushed into coarse powder, 17 kg of rehmannia glutinosa and cut into pieces, 5.7 kg of licorice crushed into coarse powder, 17 kg of Radix Ophiopogon japonicus tuber, put the pueraria root and schisandra chinensis into the extraction tank according to the final determination process, add 80 8 times (272 L) of % ethanol (V / V), heat and reflux for extraction for two hours, release the extract, re-add the same amount of 80% ethanol (V / V), heat and reflux for two hours. After the medicinal dregs are evaporated to dry ethanol, other medicinal materials are put in together, and 725.6L of 8 times of water is added respectively, and the extraction is performed for two hours, twice in total.
[0126] Combine the ethanol extract and water extract, reduce pressure, and concentrate to a solid content of about 16% (W / W). The resulting ex...
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