Process for synthesis of prulifloxacin and its pharmaceutical composition

A composition and drug technology, applied in antibacterial drugs, organic chemistry, etc., can solve the problems of complex process, high cost, long route, etc., and achieve the effects of high yield, easy operation, and simple design
CN1704419AInactive Publication Date: 2005-12-07哈尔滨健迪医药技术有限公司
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Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
哈尔滨健迪医药技术有限公司
Publication Date
2005-12-07
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention discloses a novel process for preparing (+-)-6-fluoro-1-methyl-7-[4-(5-methyl-2-oxo-1,3-dioxolen-4-yl)methyl-1-piperazinyl]-4-oxo-4H-[1,3]thiazeto[3,2-a]quinoline-3-carboxylic acid, and medicinal compositions containing the compound, which can be used for treating bacterial infection for mammals, and especially has strong effect in resisting Gram-negative bacteria.
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Description

technical field

[0001] The present invention relates to prulifloxacin ((±)-6-fluoro-1-methyl-7-[4-(5-methyl-2-oxo-1,3-dioxol-4 base) Methyl-1-piperazine]-4-oxo-4hydro-[1,3]thiazetidino[3,2-α]quinoline-3-carboxylic acid) (I) new synthetic antibacterial drug synthesis process.

[0002]

[0003] (I) technical background

[0004] Synthetic antibacterial agents widely used in the treatment of infections caused by Gram-negative bacteria include enoxacin, ofloxacin, and ciprofloxacin. However, these antibacterial preparations cannot meet the growing and refractory diseases in recent years, namely the treatment of chronic Pseudomonas aeruginosa infection and Gram-negative bacterial infection. It has good absorption, excellent pharmacokinetic properties, broad antibacterial spectrum and strong antibacterial effect, and is a clinically effective antibacterial preparation.

[0005] The antibacterial preparation was the first to be a new generation of a...

Claims

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